Ménard, M.; Ali, L.M.A.; Vardanyan, A.; Charnay, C.; Raehm, L.; Cunin, F.; Bessière, A.; Oliviero, E.; Theodossiou, T.A.; Seisenbaeva, G.A.; Gary-Bobo, M.; Durand, J.-O. Upscale Synthesis of Magnetic Mesoporous Silica Nanoparticles and Application to Metal Ion Separation: Nanosafety Evaluation. Nanomaterials2023, 13, 3155.
Ménard, M.; Ali, L.M.A.; Vardanyan, A.; Charnay, C.; Raehm, L.; Cunin, F.; Bessière, A.; Oliviero, E.; Theodossiou, T.A.; Seisenbaeva, G.A.; Gary-Bobo, M.; Durand, J.-O. Upscale Synthesis of Magnetic Mesoporous Silica Nanoparticles and Application to Metal Ion Separation: Nanosafety Evaluation. Nanomaterials 2023, 13, 3155.
Ménard, M.; Ali, L.M.A.; Vardanyan, A.; Charnay, C.; Raehm, L.; Cunin, F.; Bessière, A.; Oliviero, E.; Theodossiou, T.A.; Seisenbaeva, G.A.; Gary-Bobo, M.; Durand, J.-O. Upscale Synthesis of Magnetic Mesoporous Silica Nanoparticles and Application to Metal Ion Separation: Nanosafety Evaluation. Nanomaterials2023, 13, 3155.
Ménard, M.; Ali, L.M.A.; Vardanyan, A.; Charnay, C.; Raehm, L.; Cunin, F.; Bessière, A.; Oliviero, E.; Theodossiou, T.A.; Seisenbaeva, G.A.; Gary-Bobo, M.; Durand, J.-O. Upscale Synthesis of Magnetic Mesoporous Silica Nanoparticles and Application to Metal Ion Separation: Nanosafety Evaluation. Nanomaterials 2023, 13, 3155.
Abstract
(1) Background: The synthesis of core-shell magnetic mesoporous nanoparticles (MMSN) from phase transfer process is usually performed at 100-250 mg scale. At the gram scale, nanoparticles without core or with multicore systems are observed. (2) Methods: Iron oxide core nanoparticles (IO) were synthesized through thermal decomposition procedure of -FeO in oleic acid. Phase transfer from chloroform to water was then performed in order to wrap IO with mesoporous silica shell through the sol-gel procedure. MMSN were then functionalized with DTPA, and used for the separation of metal ions. Their toxicity was evaluated (3) Results: The phase transfer pro-cedure was crucial to obtained MMSN at large scale. Three synthesis parameters were rigorously controlled: temperature, time and glassware. Homogeneous dispersion of MMSN at the gram scale was successfully obtained. After functionalization with DTPA, the MMSN-DTPA were shown to have a strong affinity for Ni ions. Furthermore toxicity was evaluated in cells, zebrafish and through seahorse metabolic assays, and the nanoparticles were found nontoxic. (4) Conclusions: We developed a method of preparation of MMSN at the gram scale. After function-alization with DTPA, the nanoparticles were efficient in metal ion removal and separation, fur-thermore, no toxicity was noticed up to 125 µg.mL-1 in zebrafish.
Keywords
Magnetic Mesoporous Nanoparticles; Up scaled synthesis. DTPA; Metal ion separation, Toxicity
Subject
Chemistry and Materials Science, Materials Science and Technology
Copyright:
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