Saner, F.H.; Raptis, D.A.; Alghamdi, S.A.; Malagó, M.M.; Broering, D.C.; Bezinover, D. Navigating the Labyrinth: Intensive Care Challenges for Patients with Acute-on-Chronic Liver Failure. Journal of Clinical Medicine 2024, 13, 506, doi:10.3390/jcm13020506.
Saner, F.H.; Raptis, D.A.; Alghamdi, S.A.; Malagó, M.M.; Broering, D.C.; Bezinover, D. Navigating the Labyrinth: Intensive Care Challenges for Patients with Acute-on-Chronic Liver Failure. Journal of Clinical Medicine 2024, 13, 506, doi:10.3390/jcm13020506.
Saner, F.H.; Raptis, D.A.; Alghamdi, S.A.; Malagó, M.M.; Broering, D.C.; Bezinover, D. Navigating the Labyrinth: Intensive Care Challenges for Patients with Acute-on-Chronic Liver Failure. Journal of Clinical Medicine 2024, 13, 506, doi:10.3390/jcm13020506.
Saner, F.H.; Raptis, D.A.; Alghamdi, S.A.; Malagó, M.M.; Broering, D.C.; Bezinover, D. Navigating the Labyrinth: Intensive Care Challenges for Patients with Acute-on-Chronic Liver Failure. Journal of Clinical Medicine 2024, 13, 506, doi:10.3390/jcm13020506.
Abstract
Acute-on-Chronic Liver Failure (ACLF) refers to the deterioration of liver function in individuals who already have chronic liver disease. In the setting of ACLF, liver damage leads to the failure of other organs and is associated with increased short-term mortality. Optimal medical management of patients with ACLF requires implementing complex treatment strategies, often in an intensive care unit (ICU). Failure of organs other than the liver distinguishes ACLF from other critical illnesses. Although there is growing evidence supporting the current approach of ACLF management, mortality associated with this condition remains unacceptably high. In this review, we discuss considerations for ICU care of patients with ACLF and highlight areas for further research.
Medicine and Pharmacology, Medicine and Pharmacology
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