Short Note
Version 1
Preserved in Portico This version is not peer-reviewed
1-(2,5-Dimethoxy-4-nitrophenyl)piperidine and 1-(2,5-dimethoxy-4-nitrophenyl)pyrroridine
Version 1
: Received: 14 November 2023 / Approved: 14 November 2023 / Online: 15 November 2023 (09:06:32 CET)
A peer-reviewed article of this Preprint also exists.
Syeda, T.M.; Al-Shaidi, M.R.; Basri, I.; Merzouk, M.; Aldabbagh, F. 1-(2,5-Dimethoxy-4-nitrophenyl)piperidine. Molbank 2023, 2023, M1744. Syeda, T.M.; Al-Shaidi, M.R.; Basri, I.; Merzouk, M.; Aldabbagh, F. 1-(2,5-Dimethoxy-4-nitrophenyl)piperidine. Molbank 2023, 2023, M1744.
Abstract
Treatment of the non-purified mixture of dinitro isomers obtained from the nitration of 1,4-dimethoxybenzene with piperidine, led to the isolation of novel but minor adduct, 1-(2,5-dimethoxy-4-nitrophenyl)piperidine (2b) in 15% yield. Yields of nucleophilic aromatic substitution adducts are high when using purified 1,4-dimethoxy-2,5-dinitrobenzene (1b) with piperidine and pyrrolidine to give 2b and 1-(2,5-dimethoxy-4-nitrophenyl)pyrrolidine (3b) in 76% and 82%, respectively.
Keywords
benzimidazolequinone, nitration; nitrobenzene; nucleophilic aromatic substitution
Subject
Chemistry and Materials Science, Organic Chemistry
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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