PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Targets and Effects of Common Biocompounds of Hibiscus sabdariffa (Delphinidn-3-Sambubiosidin, Quercetin, and Hibiscus Acid) in Different Pathways of Human Cells According to a Bioinformatic Assay
Zúñiga-Hernández, S.R.; García-Iglesias, T.; Macías-Carballo, M.; Pérez-Larios, A.; Gutiérrez-Mercado, Y.K.; Camargo-Hernández, G.; Rodríguez-Razón, C.M. Targets and Effects of Common Biocompounds of Hibiscus sabdariffa (Delphinidin-3-Sambubiosid, Quercetin, and Hibiscus Acid) in Different Pathways of Human Cells According to a Bioinformatic Assay. Nutrients2024, 16, 566.
Zúñiga-Hernández, S.R.; García-Iglesias, T.; Macías-Carballo, M.; Pérez-Larios, A.; Gutiérrez-Mercado, Y.K.; Camargo-Hernández, G.; Rodríguez-Razón, C.M. Targets and Effects of Common Biocompounds of Hibiscus sabdariffa (Delphinidin-3-Sambubiosid, Quercetin, and Hibiscus Acid) in Different Pathways of Human Cells According to a Bioinformatic Assay. Nutrients 2024, 16, 566.
Zúñiga-Hernández, S.R.; García-Iglesias, T.; Macías-Carballo, M.; Pérez-Larios, A.; Gutiérrez-Mercado, Y.K.; Camargo-Hernández, G.; Rodríguez-Razón, C.M. Targets and Effects of Common Biocompounds of Hibiscus sabdariffa (Delphinidin-3-Sambubiosid, Quercetin, and Hibiscus Acid) in Different Pathways of Human Cells According to a Bioinformatic Assay. Nutrients2024, 16, 566.
Zúñiga-Hernández, S.R.; García-Iglesias, T.; Macías-Carballo, M.; Pérez-Larios, A.; Gutiérrez-Mercado, Y.K.; Camargo-Hernández, G.; Rodríguez-Razón, C.M. Targets and Effects of Common Biocompounds of Hibiscus sabdariffa (Delphinidin-3-Sambubiosid, Quercetin, and Hibiscus Acid) in Different Pathways of Human Cells According to a Bioinformatic Assay. Nutrients 2024, 16, 566.
Abstract
The historical and cultural use of food as a remedy for diseases is evident in societies, such as using Hibiscus sabdariffa to address conditions like hypertension and high blood glucose. The natural biocompounds in this plant, including Delphinidin-3-Sambubioside (DS3), Quercetin (QRC), and Hibiscus Acid (HA), have been linked to various health benefits. Despite individual attention, molecular targets for these compounds remain unclear. In this study, in-silico analysis employed bioinformatic tools; including Swiss Target Prediction, ShinnyGo 0.77, KEGG, and Stringdb, to identify molecular targets, pathways, and hub genes. A PubMed literature search complemented the results. DS3 demonstrated potential modifications in genes related to nitrogen and glucose metabolism, inflammation, angiogenesis, and cell proliferation, particularly affecting the PI3K-AKT pathway. QRC displayed interconnected targets across multiple pathways, with overlap with DS3 and a focus on cancer-related pathways. HA showed distinct targets, particularly associated with nervous system-related pathways. These findings highlight the need for targeted research on the molecular effects of DS3, QRC, and HA, providing valuable insights into potential therapeutic pathways.
Medicine and Pharmacology, Dietetics and Nutrition
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.