Version 1
: Received: 21 December 2023 / Approved: 21 December 2023 / Online: 24 December 2023 (15:24:32 CET)
Version 2
: Received: 26 December 2023 / Approved: 27 December 2023 / Online: 27 December 2023 (05:21:05 CET)
Colaizzo, E.; Prosperini, L.; Petrucci, A.; Perna, A. Creutzfeldt–Jakob Disease Associated with E200K Mutation and SARS-CoV2 Infection: Pure Coincidence or Neurodegenerative Acceleration? Clin. Transl. Neurosci.2024, 8, 16.
Colaizzo, E.; Prosperini, L.; Petrucci, A.; Perna, A. Creutzfeldt–Jakob Disease Associated with E200K Mutation and SARS-CoV2 Infection: Pure Coincidence or Neurodegenerative Acceleration? Clin. Transl. Neurosci. 2024, 8, 16.
Colaizzo, E.; Prosperini, L.; Petrucci, A.; Perna, A. Creutzfeldt–Jakob Disease Associated with E200K Mutation and SARS-CoV2 Infection: Pure Coincidence or Neurodegenerative Acceleration? Clin. Transl. Neurosci.2024, 8, 16.
Colaizzo, E.; Prosperini, L.; Petrucci, A.; Perna, A. Creutzfeldt–Jakob Disease Associated with E200K Mutation and SARS-CoV2 Infection: Pure Coincidence or Neurodegenerative Acceleration? Clin. Transl. Neurosci. 2024, 8, 16.
Abstract
it has been just over three years since SARS-CoV-2 viral infection was first known as causing severe acute and highly transmissible respiratory syndrome coronavirus. During one of the worst global pandemics of the last century, caused by the COVID-19 disease, under the persistent immune pressure exerted by the newest vaccines, the SARS-CoV-2 virus is fastly mutating and becoming less severe, but more contagious. On the other hand, some studies [1,2,3] indicate that the elderly COVID-19 patients or those who have reported a virulent episode of this infection, experience some long-lasting neurological complications, including encephalopathy, encephalitis, cerebrovascular disease, Parkinson’s disease (PD), Alzheimer’s disease (AD) and prion disease (PrD). So, there are several recent reports of patients [4,5] developing PrD following the SARS-CoV-2 infection, but, to the best of our knowledge, this is the first case reported in Italy on an association of the PRNP E200K somatic mutation with gCJD. The rising global prevalence neurodegenerative complications following COVID-19 disease adds urgency to the study of this potential relationship.
Keywords
genetic CJD; mutation E200K; COVID-19; prion
Subject
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Commenter: Alessia Perna
Commenter's Conflict of Interests: Author