Version 1
: Received: 22 December 2023 / Approved: 25 December 2023 / Online: 25 December 2023 (11:12:22 CET)
Version 2
: Received: 4 January 2024 / Approved: 5 January 2024 / Online: 5 January 2024 (12:13:12 CET)
Tempone, M.H.; Borges-Martins, V.P.; César, F.; Alexandrino-Mattos, D.P.; de Figueiredo, C.S.; Raony, Í.; dos Santos, A.A.; Duarte-Silva, A.T.; Dias, M.S.; Freitas, H.R.; de Araújo, E.G.; Ribeiro-Resende, V.T.; Cossenza, M.; P. Silva, H.; P. de Carvalho, R.; Ventura, A.L.M.; Calaza, K.C.; Silveira, M.S.; Kubrusly, R.C.C.; de Melo Reis, R.A. The Healthy and Diseased Retina Seen through Neuron–Glia Interactions. Int. J. Mol. Sci.2024, 25, 1120.
Tempone, M.H.; Borges-Martins, V.P.; César, F.; Alexandrino-Mattos, D.P.; de Figueiredo, C.S.; Raony, Í.; dos Santos, A.A.; Duarte-Silva, A.T.; Dias, M.S.; Freitas, H.R.; de Araújo, E.G.; Ribeiro-Resende, V.T.; Cossenza, M.; P. Silva, H.; P. de Carvalho, R.; Ventura, A.L.M.; Calaza, K.C.; Silveira, M.S.; Kubrusly, R.C.C.; de Melo Reis, R.A. The Healthy and Diseased Retina Seen through Neuron–Glia Interactions. Int. J. Mol. Sci. 2024, 25, 1120.
Tempone, M.H.; Borges-Martins, V.P.; César, F.; Alexandrino-Mattos, D.P.; de Figueiredo, C.S.; Raony, Í.; dos Santos, A.A.; Duarte-Silva, A.T.; Dias, M.S.; Freitas, H.R.; de Araújo, E.G.; Ribeiro-Resende, V.T.; Cossenza, M.; P. Silva, H.; P. de Carvalho, R.; Ventura, A.L.M.; Calaza, K.C.; Silveira, M.S.; Kubrusly, R.C.C.; de Melo Reis, R.A. The Healthy and Diseased Retina Seen through Neuron–Glia Interactions. Int. J. Mol. Sci.2024, 25, 1120.
Tempone, M.H.; Borges-Martins, V.P.; César, F.; Alexandrino-Mattos, D.P.; de Figueiredo, C.S.; Raony, Í.; dos Santos, A.A.; Duarte-Silva, A.T.; Dias, M.S.; Freitas, H.R.; de Araújo, E.G.; Ribeiro-Resende, V.T.; Cossenza, M.; P. Silva, H.; P. de Carvalho, R.; Ventura, A.L.M.; Calaza, K.C.; Silveira, M.S.; Kubrusly, R.C.C.; de Melo Reis, R.A. The Healthy and Diseased Retina Seen through Neuron–Glia Interactions. Int. J. Mol. Sci. 2024, 25, 1120.
Abstract
The retina is the sensory tissue responsible for the first stages of visual processing, with a conserved anatomy and functional architecture among vertebrates. To date, retinal eye diseases, such as diabetic retinopathy, age-related macular degeneration, retinitis pigmentosa, glaucoma and others, affect nearly 170 million people worldwide, resulting in vision loss and blindness. To tackle retinal disorders, the developing retina has been explored as a versatile model to study intercellular signaling, as it presents a broad neurochemical repertoire. Retina, dissociated and arranged as typical cultures, as mixed or neuron- and glia-enriched, and/or organized as neurospheres or as organoids are valuable to understand both neuronal and glial compartments which have contributed to reveal roles and mechanisms of transmitter systems as well as antioxidants, trophic factors, and extracellular matrix proteins. Overall, contributions in understanding neurogenesis, tissue development, differentiation, connectivity, plasticity, and cell death are widely described. A complete access to the genome of several vertebrates, as well the recent transcriptome at the single cell level at different stages of development also anticipates future advances in providing cues to target blinding diseases or retinal dysfunctions.
Keywords
retina; signaling; disease; neuron; glia
Subject
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received:
5 January 2024
Commenter:
Ricardo Augusto de Melo Reis
Commenter's Conflict of Interests:
Author
Comment:
After the submission of our manuscript entitled The healthy and diseased retina seen through neuron-glia interactions from Matheus Tempone et al, to be considered for publication in the International Journal of Molecular Sciences, we identified that the version which was submitted contained mistakes we had now corrected in this new version. For this reason I apologize for the inconvenience and request that this new version is
Commenter: Ricardo Augusto de Melo Reis
Commenter's Conflict of Interests: Author
retina seen through neuron-glia interactions from Matheus Tempone et al, to be considered for publication in the International Journal of Molecular Sciences, we identified that the version which was submitted contained mistakes we had now corrected in this new version.
For this reason I apologize for the inconvenience and request that this new version is