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Longitudinal NMR-Based Metabolomics Study Reveals How Hospitalized COVID-19 Patients Recover: Evidence of Dyslipidemia and Energy Metabolism Dysregulation
Ansone, L.; Rovite, V.; Brīvība, M.; Jagare, L.; Pelcmane, L.; Borisova, D.; Thews, A.; Leiminger, R.; Kloviņš, J. Longitudinal NMR-Based Metabolomics Study Reveals How Hospitalized COVID-19 Patients Recover: Evidence of Dyslipidemia and Energy Metabolism Dysregulation. Int. J. Mol. Sci.2024, 25, 1523.
Ansone, L.; Rovite, V.; Brīvība, M.; Jagare, L.; Pelcmane, L.; Borisova, D.; Thews, A.; Leiminger, R.; Kloviņš, J. Longitudinal NMR-Based Metabolomics Study Reveals How Hospitalized COVID-19 Patients Recover: Evidence of Dyslipidemia and Energy Metabolism Dysregulation. Int. J. Mol. Sci. 2024, 25, 1523.
Ansone, L.; Rovite, V.; Brīvība, M.; Jagare, L.; Pelcmane, L.; Borisova, D.; Thews, A.; Leiminger, R.; Kloviņš, J. Longitudinal NMR-Based Metabolomics Study Reveals How Hospitalized COVID-19 Patients Recover: Evidence of Dyslipidemia and Energy Metabolism Dysregulation. Int. J. Mol. Sci.2024, 25, 1523.
Ansone, L.; Rovite, V.; Brīvība, M.; Jagare, L.; Pelcmane, L.; Borisova, D.; Thews, A.; Leiminger, R.; Kloviņš, J. Longitudinal NMR-Based Metabolomics Study Reveals How Hospitalized COVID-19 Patients Recover: Evidence of Dyslipidemia and Energy Metabolism Dysregulation. Int. J. Mol. Sci. 2024, 25, 1523.
Abstract
Long Covid or post-acute sequelae of SARS-CoV-2 infection (PASC) can manifest as long-term symptoms in multiple organ systems, including respiratory, cardiovascular, neurological, and metabolic systems. In patients with severe COVID-19, immune dysregulation is significant, and the relationship between metabolic regulation and immune response is of great interest in determining the pathophysiological mechanisms. We aimed to characterize the metabolomic footprint for recovering severe COVID-19 patients in three consecutive time points and compare metabolite levels to controls. Our findings add proof of dysregulated amino acid metabolism in the acute phase, and dyslipidemia, glycoprotein level alterations, and energy metabolism disturbances in severe COVID-19 patients 3-4 months post hospitalization.
Keywords
COVID-19; SARS-CoV-2; Post-acute sequelae of SARS-CoV-2; metabolomics; dyslipdemia; Nuclear magnetic resonance
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.