Version 1
: Received: 2 January 2024 / Approved: 3 January 2024 / Online: 3 January 2024 (08:03:38 CET)
How to cite:
Terhune, T.; Ghafourian, T.; Deth, R. NLRP3 Inflammasome Activation by Oxidative Stress and Its Implications for Vaccination-Related Adverse Events. Preprints2024, 2024010192. https://doi.org/10.20944/preprints202401.0192.v1
Terhune, T.; Ghafourian, T.; Deth, R. NLRP3 Inflammasome Activation by Oxidative Stress and Its Implications for Vaccination-Related Adverse Events. Preprints 2024, 2024010192. https://doi.org/10.20944/preprints202401.0192.v1
Terhune, T.; Ghafourian, T.; Deth, R. NLRP3 Inflammasome Activation by Oxidative Stress and Its Implications for Vaccination-Related Adverse Events. Preprints2024, 2024010192. https://doi.org/10.20944/preprints202401.0192.v1
APA Style
Terhune, T., Ghafourian, T., & Deth, R. (2024). NLRP3 Inflammasome Activation by Oxidative Stress and Its Implications for Vaccination-Related Adverse Events. Preprints. https://doi.org/10.20944/preprints202401.0192.v1
Chicago/Turabian Style
Terhune, T., Taravat Ghafourian and Richard Deth. 2024 "NLRP3 Inflammasome Activation by Oxidative Stress and Its Implications for Vaccination-Related Adverse Events" Preprints. https://doi.org/10.20944/preprints202401.0192.v1
Abstract
The cytokine-producing nucleotide-binding domain leucine-rich repeat and pyrin-containing receptor 3 (NLRP3) inflammasome is generally recognized to play a central role in the immune response to vaccination and NLRP3 activity is known to be increased by both aluminum adjuvants and by oxidative stress. Thus, the presence of oxidative stress may place individuals at higher risk for exaggerated or prolonged inflammatory responses and related side effects from vaccination. We here examine the relationship between oxidative stress and NLRP3 inflammasome activity, particularly in the context of aluminum-adjuvanted vaccines, and its implications for subpopulations of individuals with restricted antioxidant capacity.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.