Article
Version 1
Preserved in Portico This version is not peer-reviewed
Prognostic Value of Apparent diffusion Coefficient (ADC) in Patients with Diffuse Gliomas
Version 1
: Received: 15 January 2024 / Approved: 15 January 2024 / Online: 15 January 2024 (14:25:06 CET)
A peer-reviewed article of this Preprint also exists.
Bušić, M.; Rumboldt, Z.; Čerina, D.; Bušić, Ž.; Dolić, K. Prognostic Value of Apparent Diffusion Coefficient (ADC) in Patients with Diffuse Gliomas. Cancers 2024, 16, 681. Bušić, M.; Rumboldt, Z.; Čerina, D.; Bušić, Ž.; Dolić, K. Prognostic Value of Apparent Diffusion Coefficient (ADC) in Patients with Diffuse Gliomas. Cancers 2024, 16, 681.
Abstract
This study aimed to evaluate potential posttreatment changes in ADC values within the tissue surrounding the enhancing lesion, particularly in areas not exhibiting MRI characteristics of in-volvement. Additionally, the objective was to investigate the correlation between ADC values, treatment response, and survival outcomes in individuals diagnosed with gliomas.
This retrospective study included a total of 49 patients that underwent either stereotactic biopsy or maximal surgical resection. Histologically confirmed as Grade III or IV gliomas, all cases adhered to the 2016 and 2021 WHO classifications, with subsequent radio-chemotherapy administered post-surgery. Patients were divided into two groups: short and long survival group. Baseline and follow-up MRI scans were obtained on a 1.5T MRI scanner. Two ROI circles were positioned near the enhancing area, one ROI in the NAWM ipsilateral to the neoplasm and another symmetrically in the contralateral hemisphere on ADC maps.
At follow-up there was a significant difference in both ipsilateral and contralateral NAWM be-tween the two groups, -0.0857 (p=0.004) and -0.0607 (p=0.037), respectively. There was a weak negative correlation between survival and ADC values in ipsilateral and contralateral NAWM at the baseline with the correlation coefficient -0.328 (p=0.02) and -0.302 (p=0.04), respectively. The correlation was stronger at the follow-up.
The findings indicate that ADC values in normal appearing white matter (NAWM) may function as a prognostic biomarker in patients with diffuse gliomas.
Keywords
glioma, magnetic resonance imaging, apparent diffusion coefficient,biomarkers
Subject
Medicine and Pharmacology, Oncology and Oncogenics
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comments (0)
We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.
Leave a public commentSend a private comment to the author(s)
* All users must log in before leaving a comment