Della Vecchia, A.; De Luca, C.; Becattini, L.; Curto, L.; Ferrari, E.; Siciliano, G.; Gori, S.; Baldacci, F. Beyond Pain Relief: Unveiling the Multifaceted Impact of Anti-CGRP/R mAbs on Comorbid Symptoms in Resistant Migraine Patients. Biomedicines2024, 12, 677.
Della Vecchia, A.; De Luca, C.; Becattini, L.; Curto, L.; Ferrari, E.; Siciliano, G.; Gori, S.; Baldacci, F. Beyond Pain Relief: Unveiling the Multifaceted Impact of Anti-CGRP/R mAbs on Comorbid Symptoms in Resistant Migraine Patients. Biomedicines 2024, 12, 677.
Della Vecchia, A.; De Luca, C.; Becattini, L.; Curto, L.; Ferrari, E.; Siciliano, G.; Gori, S.; Baldacci, F. Beyond Pain Relief: Unveiling the Multifaceted Impact of Anti-CGRP/R mAbs on Comorbid Symptoms in Resistant Migraine Patients. Biomedicines2024, 12, 677.
Della Vecchia, A.; De Luca, C.; Becattini, L.; Curto, L.; Ferrari, E.; Siciliano, G.; Gori, S.; Baldacci, F. Beyond Pain Relief: Unveiling the Multifaceted Impact of Anti-CGRP/R mAbs on Comorbid Symptoms in Resistant Migraine Patients. Biomedicines 2024, 12, 677.
Abstract
Objective: The study aimed to evaluate the effects of monoclonal antibodies (mAbs) acting on the calcitonin gene-related peptide (CGRP) or its receptor (anti-CGRP/R mAbs) on comorbid symptoms of depression, anxiety, and fatigue in migraine patients resistant to traditional prophylaxis.
Methods: The study was an open-label prospective study assessing comorbidities in patients with high frequency (HFEM) and chronic migraine (CM), medication overuse headache (MOH), and resistance to traditional prophylaxis treated with anti-CGRP/R mAbs for 3 months.
Results: 77 patients were enrolled with either HFEM (21%) or CM (79%) with or without MOH (56% and 44% respectively). We identified 21 non-responders (27%) and 56 responders (73%), defined on the reduction ≥ 50% of headache frequency. The two groups were highly homogeneous for investigated comorbidities. Disease severity in terms of headache frequency, migraine-related disability, and affective comorbid symptoms were reduced in both groups with different thresholds; allodynia and fatigue were ameliorated only in responders.
Conclusion: anti-CGRP/R antibodies improve pain together with affection, fatigue, and sensory sensitization in migraine patients.
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
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