Review
Version 1
Preserved in Portico This version is not peer-reviewed
Brain-Derived Neurotrophic Factor, Nociception and Pain
Version 1
: Received: 8 February 2024 / Approved: 9 February 2024 / Online: 9 February 2024 (13:23:09 CET)
A peer-reviewed article of this Preprint also exists.
Merighi, A. Brain-Derived Neurotrophic Factor, Nociception, and Pain. Biomolecules 2024, 14, 539. Merighi, A. Brain-Derived Neurotrophic Factor, Nociception, and Pain. Biomolecules 2024, 14, 539.
Abstract
This review article discusses the involvement of the Brain-Derived Neurotrophic Factor (BDNF) in the control of pain. BDNF, a neurotrophin known for its essential role in neuronal survival and plasticity, has garnered significant attention for its potential implications as a modulator of nociception and pain. This comprehensive review aims to provide insights into the multifaceted interactions between BDNF and pain pathways, encompassing both physiological and pathological pain conditions. I delve into the molecular mechanisms underlying BDNF's involvement in pain processing and discuss potential therapeutic applications of BDNF and its mimetics in managing pain. Furthermore, I highlight recent advancements and challenges in translating BDNF-related research into clinical practice.
Keywords
BDNF; Nociception; Pain; Neurons; Glia; Presynaptic mechanisms; Postsynaptic mechanisms; LTP; Neuropeptides
Subject
Biology and Life Sciences, Neuroscience and Neurology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comments (0)
We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.
Leave a public commentSend a private comment to the author(s)
* All users must log in before leaving a comment