Galijasevic, M.; Steiger, R.; Treichl, S.A.; Ho, W.M.; Mangesius, S.; Ladenhauf, V.; Deeg, J.; Gruber, L.; Ouaret, M.; Regodic, M.; Lenhart, L.; Pfausler, B.; Grams, A.E.; Petr, O.; Thomé, C.; Gizewski, E.R. Could Phosphorous MR Spectroscopy Help Predict the Severity of Vasospasm? A Pilot Study. Diagnostics2024, 14, 841.
Galijasevic, M.; Steiger, R.; Treichl, S.A.; Ho, W.M.; Mangesius, S.; Ladenhauf, V.; Deeg, J.; Gruber, L.; Ouaret, M.; Regodic, M.; Lenhart, L.; Pfausler, B.; Grams, A.E.; Petr, O.; Thomé, C.; Gizewski, E.R. Could Phosphorous MR Spectroscopy Help Predict the Severity of Vasospasm? A Pilot Study. Diagnostics 2024, 14, 841.
Galijasevic, M.; Steiger, R.; Treichl, S.A.; Ho, W.M.; Mangesius, S.; Ladenhauf, V.; Deeg, J.; Gruber, L.; Ouaret, M.; Regodic, M.; Lenhart, L.; Pfausler, B.; Grams, A.E.; Petr, O.; Thomé, C.; Gizewski, E.R. Could Phosphorous MR Spectroscopy Help Predict the Severity of Vasospasm? A Pilot Study. Diagnostics2024, 14, 841.
Galijasevic, M.; Steiger, R.; Treichl, S.A.; Ho, W.M.; Mangesius, S.; Ladenhauf, V.; Deeg, J.; Gruber, L.; Ouaret, M.; Regodic, M.; Lenhart, L.; Pfausler, B.; Grams, A.E.; Petr, O.; Thomé, C.; Gizewski, E.R. Could Phosphorous MR Spectroscopy Help Predict the Severity of Vasospasm? A Pilot Study. Diagnostics 2024, 14, 841.
Abstract
One of the main causes of the dismal prognosis in patients who survive the initial bleeding after aneurysmal subarachnoidal hemorrhage is the delayed cerebral ischaemia caused by vasospasm. Studies suggest that cerebral magnesium and pH may potentially play a role in the pathophysiology of this adverse event. Using phosphorous magnetic resonance spectrocopy (31P-MRS) we calculated the cerebral magnesium (Mg) and pH level in 13 patients who suffered aSAH. The values between the group that developed clinically significant vasospasm (n=7) and the group that did not (n=6) were compared. The results of this study showed significantly lower cerebral Mg levels (p=0.019) and higher pH (p<0.001) in cumulative group (all brain voxels together) in patients who developed clinically significant vasospasm. Further clinical studies on a larger group of carefully selected patients are needed in order to predict clinically significant vasospasm.
Medicine and Pharmacology, Neuroscience and Neurology
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