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Reply to León et al. (2024): Interpretation and Use of In-Field Diagnostics for High Pathogenicity Avian Influenza (HPAI) in Antarctica– A Cautionary Tale
Version 1
: Received: 22 April 2024 / Approved: 23 April 2024 / Online: 23 April 2024 (05:30:40 CEST)
How to cite:
Wille, M.; Vanstreels, R. E. T.; Uhart, M.; Reid, S.; Dewar, M.; Banyard, A. C. Reply to León et al. (2024): Interpretation and Use of In-Field Diagnostics for High Pathogenicity Avian Influenza (HPAI) in Antarctica– A Cautionary Tale. Preprints2024, 2024041498. https://doi.org/10.20944/preprints202404.1498.v1
Wille, M.; Vanstreels, R. E. T.; Uhart, M.; Reid, S.; Dewar, M.; Banyard, A. C. Reply to León et al. (2024): Interpretation and Use of In-Field Diagnostics for High Pathogenicity Avian Influenza (HPAI) in Antarctica– A Cautionary Tale. Preprints 2024, 2024041498. https://doi.org/10.20944/preprints202404.1498.v1
Wille, M.; Vanstreels, R. E. T.; Uhart, M.; Reid, S.; Dewar, M.; Banyard, A. C. Reply to León et al. (2024): Interpretation and Use of In-Field Diagnostics for High Pathogenicity Avian Influenza (HPAI) in Antarctica– A Cautionary Tale. Preprints2024, 2024041498. https://doi.org/10.20944/preprints202404.1498.v1
APA Style
Wille, M., Vanstreels, R. E. T., Uhart, M., Reid, S., Dewar, M., & Banyard, A. C. (2024). Reply to León <em>et al</em>. (2024): Interpretation and Use of In-Field Diagnostics for High Pathogenicity Avian Influenza (HPAI) in Antarctica– A Cautionary Tale. Preprints. https://doi.org/10.20944/preprints202404.1498.v1
Chicago/Turabian Style
Wille, M., Meagan Dewar and Ashley C Banyard. 2024 "Reply to León <em>et al</em>. (2024): Interpretation and Use of In-Field Diagnostics for High Pathogenicity Avian Influenza (HPAI) in Antarctica– A Cautionary Tale" Preprints. https://doi.org/10.20944/preprints202404.1498.v1
Abstract
High pathogenicity avian influenza (HPAI) H5N1 clade 2.3.4.4b continues to have a substantial impact on wildlife, globally. A recent study has described the putative detection of HPAI in clinically healthy penguins, and those which were fitted with satellite tags reportedly engaged in apparently normal foraging behaviour in the months following sample collection. Herein we investigate the diagnostic approach utilised, and reveal that while the authors likely did detect subtype H5 influenza A virus, the most parsimonious conclusion is that they detected low pathogenicity H5 rather than HPAI H5N1. In response, we have provided an overview key considerations when selecting a diagnostic and outline published diagnostic assays that should be considered for future studies.
Keywords
avian influenza; LPAI; HPAI; high pathogenicity avian influenza; panguins; Antarctica
Subject
Biology and Life Sciences, Virology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.