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Detection of Low-Concentration Biological Samples Based on a QBIC Terahertz Metamaterial Sensor
Version 1
: Received: 15 May 2024 / Approved: 15 May 2024 / Online: 15 May 2024 (10:51:29 CEST)
A peer-reviewed article of this Preprint also exists.
Dong, B.; Wei, B.; Wei, D.; Ke, Z.; Ling, D. Detection of Low-Concentration Biological Samples Based on a QBIC Terahertz Metamaterial Sensor. Sensors 2024, 24, 3649. Dong, B.; Wei, B.; Wei, D.; Ke, Z.; Ling, D. Detection of Low-Concentration Biological Samples Based on a QBIC Terahertz Metamaterial Sensor. Sensors 2024, 24, 3649.
Abstract
Quasi-bound state in the continuum (QBIC) can effectively enhance the interaction of terahertz (THz) wave with matters due to the tunable high-Q property, which has a strong potential application in detection of low-concentration biological samples in the THz band. In this paper, a novel THz metamaterial sensor with a double-chain separated resonant cavity structure based on QBIC is designed and fabricated. The process of excitation of the QBIC mode is verified and the structural parameters are optimized after considering the ohmic loss by simulations. The simulated refractive index sensitivity of the sensor is up to 544 GHz/RIU, much higher than those of recently reported THz metamaterial sensors. Sensing sensitivity of the proposed metamaterial sensor is confirmed in experiment by detecting low-concentration lithium citrate (LC) and bovine serum albumin (BSA) solutions. The limits of detection (LoDs) are obtained to be 0.0025 mg/mL (12 μM) for LC and 0.03125 mg/mL (0.47 μM) for BSA, respectively, both of which excel over most of reported results in previous studies. These results indicate that the proposed THz metamaterial sensor has excellent sensing performances and can well be applied to the detection of low concentration biological samples.
Keywords
Terahertz; Metamaterial sensor; Quasi-bound state in the continuum; Lithium citrate; Bovine serum albumin; Limit of detection
Subject
Physical Sciences, Optics and Photonics
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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