Review
Version 1
Preserved in Portico This version is not peer-reviewed
Chiral non Aromatic Nitrogen-Heterocycles by Asymmetric Intramolecular Haloamination and Haloamidation
Version 1
: Received: 24 May 2024 / Approved: 27 May 2024 / Online: 27 May 2024 (09:58:07 CEST)
A peer-reviewed article of this Preprint also exists.
Orena, M.; Rinaldi, S. Chiral Nonaromatic Nitrogen-Heterocycles by Asymmetric Intramolecular Haloamination and Haloamidation. Organics 2024, 5, 163-204. Orena, M.; Rinaldi, S. Chiral Nonaromatic Nitrogen-Heterocycles by Asymmetric Intramolecular Haloamination and Haloamidation. Organics 2024, 5, 163-204.
Abstract
This review deals with the functionalization of double bonds carried out in the presence of a chiral catalyst exploiting the intramolecular attack to haliranium ions by nucleophilic nitrogen of amides or carbamates prepared from achiral aminoalkenes, and the C-N bonds formation leads to highly enantioenriched non-aromatic heterocycles. A range of protocols are reported, emphasizing the synthesis of many natural and biologically active products of pharmacological interest prepared according to this methodology.
Keywords
non-aromatic heterocycles; haloamination; haloamidation; haliranium ion; stereoselectivity; chiral catalysts
Subject
Chemistry and Materials Science, Organic Chemistry
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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