Version 1
: Received: 7 June 2024 / Approved: 10 June 2024 / Online: 10 June 2024 (09:28:14 CEST)
How to cite:
Soto, M. E.; Manzano-Pech, L.; Guarner-Lans, V.; Palacios-Chavarría, A.; Valdez-Vázquez, R. R.; Martínez-Memije, R.; El-Hafidi, M.; Rodríguez-Fierros, F. L.; Pérez-Torres, I. Preliminary Study on the Restoration of the Phospholipid Profile in Serum from Patients with COVID-19 by Treatment with Vitamin E. Preprints2024, 2024060539. https://doi.org/10.20944/preprints202406.0539.v1
Soto, M. E.; Manzano-Pech, L.; Guarner-Lans, V.; Palacios-Chavarría, A.; Valdez-Vázquez, R. R.; Martínez-Memije, R.; El-Hafidi, M.; Rodríguez-Fierros, F. L.; Pérez-Torres, I. Preliminary Study on the Restoration of the Phospholipid Profile in Serum from Patients with COVID-19 by Treatment with Vitamin E. Preprints 2024, 2024060539. https://doi.org/10.20944/preprints202406.0539.v1
Soto, M. E.; Manzano-Pech, L.; Guarner-Lans, V.; Palacios-Chavarría, A.; Valdez-Vázquez, R. R.; Martínez-Memije, R.; El-Hafidi, M.; Rodríguez-Fierros, F. L.; Pérez-Torres, I. Preliminary Study on the Restoration of the Phospholipid Profile in Serum from Patients with COVID-19 by Treatment with Vitamin E. Preprints2024, 2024060539. https://doi.org/10.20944/preprints202406.0539.v1
APA Style
Soto, M. E., Manzano-Pech, L., Guarner-Lans, V., Palacios-Chavarría, A., Valdez-Vázquez, R. R., Martínez-Memije, R., El-Hafidi, M., Rodríguez-Fierros, F. L., & Pérez-Torres, I. (2024). Preliminary Study on the Restoration of the Phospholipid Profile in Serum from Patients with COVID-19 by Treatment with Vitamin E. Preprints. https://doi.org/10.20944/preprints202406.0539.v1
Chicago/Turabian Style
Soto, M. E., Félix Leao Rodríguez-Fierros and Israel Pérez-Torres. 2024 "Preliminary Study on the Restoration of the Phospholipid Profile in Serum from Patients with COVID-19 by Treatment with Vitamin E" Preprints. https://doi.org/10.20944/preprints202406.0539.v1
Abstract
SARS-CoV-2 is an obligatory intracellular pathogen that requires of a lipid bilayer membrane for its transport, to build its nucleocapsid envelope and to fuse with the host cell. The biological membranes are constituted by phospholipids (PLs) and vitamin E (Vit E) protects them from oxidative stress (OS). The aim of this study was to demonstrate if the treatment with Vit E restores the modified profile of the FA in PLs in serum from patients with coronavirus disease-19 (COVID-19). We evaluated Vit E, total fatty acids (TFA), fatty acid of the phospholipids (FAPL), total phospholipids (TPLs), 8-isoprostane, thromboxane B2 (TXB2), prostaglandins (PGE2 and 6-keto-PGF1α), interleukin-6 (IL-6) and C-reactive protein (CRP) in serum from 22 COVID-19 patients before and after treatment with Vit E and compared the values with those from 23 healthy subjects (HS). COVID-19 patients showed a decrease in Vit E, TPLs, FAPL and TFA in serum in comparison to HS (p≤0.01) and Vit E treatment restored their levels (p≤0.04). Likewise, there was an increase IL-6 and CRP in COVID-19 patients in comparison with HS (p≤0.001) and the treatment with Vit E decreased their levels (p≤0.001). Treatment with Vit E contributes to restore the modified profile of the PLs in the SARS-CoV-2 infection and this leads to a decrease of OS and of the inflammatory process.
Public Health and Healthcare, Public Health and Health Services
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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