Single-Molecule Tracking in Live Cell without Immobilization or without Hydrodynamic Flow by Simulations: Thermodynamic Jitter

Zeno Földes-Papp; Gerd Baumann

doi:10.20944/preprints202406.0629.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 9 June 2024 / Approved: 10 June 2024 / Online: 11 June 2024 (08:12:32 CEST)

Experiments to measure a single molecule/particle, i.e. an individual molecule/particle, at room temperature or under physiological conditions without immobilization, for example on a surface, or without significant hydrodynamic flow have so far failed. This failure has given impetus to the underlying theory of Brownian molecular motion towards its stochastic due to diffusion. Quantifying the thermodynamic jitter of molecules/particles inspires many and forms the theoretical basis of single-molecule/single-particle biophysics and biochemistry. For the first time, our simulation results for a live cell (cytoplasm) show that the tracks of individual single molecules are localized in Brownian motion, while there is fanning out in fractal diffusion (anomalous diffusion).

individual molecule tracking; individual molecule; single molecule; diffusion; thermodynamic jitter; live cell; cytoplasm; liquids; room temperature; continuous-time random walk (CTRW); Brownian motion; anomalous motion; computer simulation

Physical Sciences, Biophysics

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Single-Molecule Tracking in Live Cell without Immobilization or without Hydrodynamic Flow by Simulations: Thermodynamic Jitter

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