Version 1
: Received: 15 June 2024 / Approved: 16 June 2024 / Online: 17 June 2024 (07:57:15 CEST)
How to cite:
Hernández-Urbán, A. J.; Drago-Serrano, M.-E.; Reséndiz-Albor, A. A.; Sierra-Ramírez, J. A.; Guzmán-Mejia, F.; Oros-Pantoja, R.; Godinez-Victoria, M. Moderate Aerobic Exercise Induces the Homeostatic IgA Generation in Senile Mice. Preprints2024, 2024061077. https://doi.org/10.20944/preprints202406.1077.v1
Hernández-Urbán, A. J.; Drago-Serrano, M.-E.; Reséndiz-Albor, A. A.; Sierra-Ramírez, J. A.; Guzmán-Mejia, F.; Oros-Pantoja, R.; Godinez-Victoria, M. Moderate Aerobic Exercise Induces the Homeostatic IgA Generation in Senile Mice. Preprints 2024, 2024061077. https://doi.org/10.20944/preprints202406.1077.v1
Hernández-Urbán, A. J.; Drago-Serrano, M.-E.; Reséndiz-Albor, A. A.; Sierra-Ramírez, J. A.; Guzmán-Mejia, F.; Oros-Pantoja, R.; Godinez-Victoria, M. Moderate Aerobic Exercise Induces the Homeostatic IgA Generation in Senile Mice. Preprints2024, 2024061077. https://doi.org/10.20944/preprints202406.1077.v1
APA Style
Hernández-Urbán, A. J., Drago-Serrano, M. E., Reséndiz-Albor, A. A., Sierra-Ramírez, J. A., Guzmán-Mejia, F., Oros-Pantoja, R., & Godinez-Victoria, M. (2024). Moderate Aerobic Exercise Induces the Homeostatic IgA Generation in Senile Mice. Preprints. https://doi.org/10.20944/preprints202406.1077.v1
Chicago/Turabian Style
Hernández-Urbán, A. J., Rigoberto Oros-Pantoja and Marycarmen Godinez-Victoria. 2024 "Moderate Aerobic Exercise Induces the Homeostatic IgA Generation in Senile Mice" Preprints. https://doi.org/10.20944/preprints202406.1077.v1
Abstract
T-cell independent (TI) pathway activated by microbiota results in the generation of low-affinity homeostatic IgA with a critical role in intestinal homeostasis. Moderate aerobic exercise (MAE) provides a beneficial impact on intestinal immunity but the action of MAE on TI-IgA generation under senescence conditions is unknown. This study aimed to determine the effects of long-term MAE on TI-IgA production in young (3 months old) BALB/c mice exercised until adulthood (6 months) or aging (24 months). Lamina propria (LP) from the small intestine was obtained to determine B cells and plasma cells sub-populations by flow cytometry and molecular factors related to class switch recombination (TSLP/APRIL/BAFF/iNOS/RDH) and synthesis of IgA (α-chain/IL-6/IL-21/TGF-β); and epithelial cells to evaluate IgA-transitosis (pIgR/TNFα/IFN-/IL-4), by RT-qPCR technique. Results were compared with data obtained from sedentary age-matched mice. Statistical analysis was computed with ANDOVA and P<0.05 was considered as statistically significant difference. Under senescence conditions MAE promoted the B cell and IgA+B cells and APRIL that may im-prove the intestinal response and ameliorated the inflammatory environment associated pre-sumably with the downmodulation of pIgR. Data suggested that MAE improved the IgA and downmodulate the cytokine pro-inflammatory expression favoring homeostatic conditions in aging.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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