MR protocol optimization for Hepatobiliary Phase Imaging with Gadoxetic Acid for 1.5T: Comparison Between Breath-Hold T1-weighted and High Resolution Navigated 3D T1-weighted sequences

Eliseo Picchi; Valentina Ferrazzoli; Valeria Liberto; Luca Toti; Raffaella Giocondo; Valerio Da Ros; Noemi Pucci; Silvia Minosse; Francesco Garaci; Francesca Di Giuliano

doi:10.20944/preprints202406.1104.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 16 June 2024 / Approved: 17 June 2024 / Online: 17 June 2024 (08:06:12 CEST)

Background and Objectives To compare navigator-gated three-dimensional T1-weighted gradient-echo sequences (NG-3D T1W-GRE) with standard breath-hold T1W-GRE (BH T1W-GRE) for the detection of HCC nodules in patients with chronic viral hepatitis which undergo at magnetic resonance imaging (MRI) using gadoxetic acid. Methods and materials We evaluated 58 patients with hepatic nodules at least 1 cm in diameter detected by ultrasound who underwent liver MRI including NG-3D T1W-GRE sequences and breath hold T1-weighted gradient-echo sequences with different flip angles(FA) at 10-25-40° after contrast administration of gadoxetic acid at magnetic scanner operating at1.5 Tesla. Image quality and relative hepatic and nodular enhancement were evaluated by three blinded reviewers. Results In these patients, image quality of NG-3D T1W-GRE was assessed significantly better than quality of BHT1W- GRE (P < 0.005) and relative enhancement was significantly higher than that of BH- T1W-GRE ( P

Magnetic Resonance; Gadoxetic Acid; High Resolution Navigated 3D; Hepatocarcinoma

Medicine and Pharmacology, Gastroenterology and Hepatology

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MR protocol optimization for Hepatobiliary Phase Imaging with Gadoxetic Acid for 1.5T: Comparison Between Breath-Hold T1-weighted and High Resolution Navigated 3D T1-weighted sequences

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