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Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Exploring the Bioactive Potential of Moroccan Lemongrass (Cymbopogon citratus): Investigations on molecular weight distribution, antioxidant and antimicrobial potentials

Version 1 : Received: 20 June 2024 / Approved: 20 June 2024 / Online: 21 June 2024 (11:29:58 CEST)

How to cite: Tazi, A.; El moujahed, S.; Jaouad, N.; Saghrouchni, H.; Al-Ashkar, I.; Liu, L.; Errachidi, F. Exploring the Bioactive Potential of Moroccan Lemongrass (Cymbopogon citratus): Investigations on molecular weight distribution, antioxidant and antimicrobial potentials. Preprints 2024, 2024061472. https://doi.org/10.20944/preprints202406.1472.v1 Tazi, A.; El moujahed, S.; Jaouad, N.; Saghrouchni, H.; Al-Ashkar, I.; Liu, L.; Errachidi, F. Exploring the Bioactive Potential of Moroccan Lemongrass (Cymbopogon citratus): Investigations on molecular weight distribution, antioxidant and antimicrobial potentials. Preprints 2024, 2024061472. https://doi.org/10.20944/preprints202406.1472.v1

Abstract

In the Lemongrass (Cymbopogon citratus), the investigations showed a wide range of active molecules their biological properties. However, most of these studies were conducted on the wid varieties, while cultivated plan addressed. This study aimed to characterize the biomolecules and biological activities of Lemongrass growing us African conditions sons in in Marocco. Marocco. Phenolic compound profiles of aqueous (AE) E) ethanol ethanol (EE), (EE), and methanol (ME) extract: fractions were obtained with steric exclusion chromatography on Sephadex 050 gel and identified by LC-MS/MS polyphenols (TPC), flavonoids (TFC), and antioxidant activities (FRAP: scavenging value and TAC: Total Antioxidant C the fraction were evaluated as well as the antimicrobial activity Obtained results showed that the ME contained e compounds (ie. Apigenine-7-0-rutinoside and myricitine-3-0-rutinoside). The AE showed the presence of five mole kaemiferol-3-0-glucuronide), while EE showed the presence of three molecules (Le. Quercetine-3-0-rutinoside). Reg chemical characterization, the rization, e highest value of Total phenolic content (TPC) was obtained in conten btained in AE ΑΕ (25) (4.60-0.29 mg highest value of Total flavonoids content (TFC) was obtained Ined in ME (29) (0.7±0.08 mg/g). Concerning the antioxide the highest FRAP was obtained in ME (29) (97.89%) and the highest total antioxidant capacity (TAC) was obtained (89.89%) Correlation between FRAP, TPC, and TFC was noted poly in fractions of AE and ME. All tested extracts of and their fractions showed a significant antimicrobial effect. The lowest minimum inhibitory concentration (MIC) wa for ME against E. col. Extracts biological activities and their fractions were governed by their active molecules. Ther new and clarify a novel aspect of bioactive molecules in the extracts of cultivated C. citratus Equaly, throughout this we clarified the relationship between identified molecules and their biological properties including antioxidant and comparative studies new activities, which is new for the study area. This study is suggested to be a reference. assays of other biological activities for the study plant

Keywords

lemongrass; chemical characterisation; antioxidant activity; antimicrobial activity

Subject

Biology and Life Sciences, Biology and Biotechnology

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