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Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Efficacy of Interferon-γ (Ingaron) Against Tuberculosis in BALB/c Mouse Mode

Version 1 : Received: 27 June 2024 / Approved: 27 June 2024 / Online: 27 June 2024 (13:54:30 CEST)

How to cite: Vasileva, I. A.; Samoilova, A. G.; Abramchenko, A. V.; Avdeev, V. V.; Vinokurov, A. S.; Romanova, M. Y.; Kayukova, S. I. Efficacy of Interferon-γ (Ingaron) Against Tuberculosis in BALB/c Mouse Mode. Preprints 2024, 2024061950. https://doi.org/10.20944/preprints202406.1950.v1 Vasileva, I. A.; Samoilova, A. G.; Abramchenko, A. V.; Avdeev, V. V.; Vinokurov, A. S.; Romanova, M. Y.; Kayukova, S. I. Efficacy of Interferon-γ (Ingaron) Against Tuberculosis in BALB/c Mouse Mode. Preprints 2024, 2024061950. https://doi.org/10.20944/preprints202406.1950.v1

Abstract

Interferon-gamma (IFN-γ) is an important cytokine in host defense against tuberculosis infection. In some cases, administration of IFN-γ during tuberculosis infection can promote faster cure. In the present work, we have shown that in a mouse model, human interferon-gamma, exhibits some anti-tuberculosis activity, especially in combination with isoniazid.

Keywords

tuberculosis, IFN-γ, antitubercular agent, lung pathology

Subject

Medicine and Pharmacology, Medicine and Pharmacology

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