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Preprint REVIEW | doi:10.20944/preprints202306.0559.v1

Cartilage Conduction Hearing Aids in Clinical Practice

Tadashi Nishimura, Hiroshi Hosoi, Ryota Shimokura, Tadashi Kitahara

Subject: Medicine And Pharmacology, Otolaryngology Keywords: Bone conduction; Cartilage conduction; Hearing device; Amplification; Aural atresia; Canal stenosis; Conductive hearing loss; Chronic otitis media

Online: 7 June 2023 (13:22:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0232.v1

Management of Cartilage-Conduction Hearing Aids in Pediatric Patients

Satomi Yakawa, Tomoko Sugiuchi, Rika Myojin, Takako Murakami, Kiyoko Sato, Yuki Miyoshi, Yuichiro Sugio

Subject: Medicine And Pharmacology, Otolaryngology Keywords: Atresia; Cartilage conduction hearing aids; Conductive hearing loss; Infant

Online: 4 July 2023 (12:36:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0315.v2

Biocompatibility of 3D Printed Methacrylate for Hearing Aids and Inner Ear Devices

Frank Alifui-Segbaya, Roy George

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: 3D printing; biocompatibility; hearing aids; methacrylates; zebrafish embryo model.

Online: 24 July 2018 (12:09:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1883.v1

A Non-Surgical Wearable Option for a Bone Conduction Implantable Device: A Comparative Study with Conventional Bone Conduction Hearing Aids

Federica Di Berardino, Giovanni Ciavarro, Giulia Fumagalli, Claudia Albanese, Enrico Pasanisi, Diego Zanetti, Vincenzo Vincenti

Subject: Medicine And Pharmacology, Otolaryngology Keywords: Bone Conduction Implantable Device; Bone Conduction Hearing Aids

Online: 27 August 2024 (03:16:55 CEST)

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Objectives. To compare the audiological benefits of a non-implantable wearing option of a bone conduction (BC) implant mounted on an arch (SoundArc) to traditional BC hearing aids (HA) mounted on eyeglasses (BCHA) in patients with moderate to severe conductive or mixed hearing loss. Methods: A preliminary cross-sectional observational prospective cohort study was conducted at a Tertiary Audiological Department, University Hospital. Fourteen adults with conductive or mixed hearing loss (PTA at 0.5-1-2-4 KHz = 67 ± 15 dB HL) had been wearing conventional BCHA on eyeglasses for at least 3 years, and refused the surgical implantation of a BC hearing implant (BCHI). Unaided and aided pure-tone AC and BC thresholds and speech test in quiet and in noise were recorded at baseline and in two different settings: with a BCHI mounted on SoundArc®, and with their own BCHA with two couplers, mounted on eyeglasses. International Inventory for Hearing Aids [IOI – HA], the Hearing Handicap Inventory [HHIA/E], Speech, Spatial, Qualities of Hearing Scale [SSQ], a 10-scores visuo-analogic scale [VAS], and Fatigue impact scale [FIS] score were asked in both conditions. Results: a statistical significative functional gain was observed for both settings. (p=.0001) Better speech perception performances in quiet and in noise were observed with SoundArc compared to their conventional BCHA on eyeglasses (word repetition score in noise improvement of +19.3 at SNR +10 dB, p=.002; + 12.1 at SNR 0 dB, p=.006; and +11.4 at SNR -10 dB, p=.002) No significant differences were found in IOI–HA, FIS, and HHIA/E scores, while significative better SSQ scores in all domains were reported for SoundArc. (p=.0038) Conclusions: Although patients were accustomed to their BCHA on eyeglasses, the non-implanted wearable option of the BCHI proved to be a viable alternative in adult patients with conductive or mixed hearing loss unable to receive or refusing BCHI surgery.

Preprint ARTICLE | doi:10.20944/preprints202302.0035.v1

Hearing Aids Reduce Self-Perceived Difficulties in Noise for Listeners with Normal Audiograms

Kiri Mealings, Joaquin T. Valderrama, Jorge Mejia, Ingrid Yeend, Elizabeth F. Beach, Brent Edwards

Subject: Medicine And Pharmacology, Otolaryngology Keywords: Speech-in-noise hearing difficulties; Hidden hearing loss (HHL); hearing aids; self-report; Reaction time; Ecologically momentary assessment (EMA)

Online: 2 February 2023 (08:37:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.0512.v1

Evidence On Viral Suppression Supports Scaling-Up Transition To Dolutegravir-Based Regimens In Pediatric Populations In Cameroon: A Multicentre Baseline Assessment For The Cipher-Adola Study

Joseph FOKAM, Yagai Bouba, Rogers Awoh Ajeh, Dominik Tameza Guebiapsi, Suzane Essamba, Albert Franck Zeh Meka, Ebiama Lifanda, Rose Armelle Ada, Yakouba Liman, Nancy Barbara Mbengono, Audrey Raissa Dzaddi Djomo, Suzie Ndiang Tetang, Samuel Martin Sosso, Jocelyne Carmen Babodo, Olivia Francette Ndomo Ambomo, Edith Michele Temgoua, Caroline Medouane, Sabine Ndejo Atsinkou, Justin Leonel Mvogo, Roger Martin Onana, Jean de Dieu Anoubissi, Alice Ketchaji, Alex Durand Nka, Davy-Hyacinthe Anguechia Gouissi, Aude Christelle Ka’e, Nadine Nguendjoung Fainguem, Rachel Simo Kamgaing, Désiré Augustin Komego Takou, Michel Carlos Tommo Tchouaket, Ezechiel Ngoufack Jagni Semengue, Marie Atsama Amougou, Julius Nwobegahay, Comfort Vuchas, Anna Nya Nsimen, Bertrand Bille Eyoum, Sandra kenmegne Gatchuessi, Francis Ndongo Ateba, Daniel Kesseng, Serge Clotaire Billong, Daniele Armenia, Maria Mercedes Santoro, Francesca Ceccherini-Silberstein, Paul Ndombo Koki, Hadja Cherif Hamsatou, Vittorio Colizzi, Alexis Ndjolo, Carlo Federico Perno, Anne-Cécile Zoung-Kanyi Bissek

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Virological suppression; low level viremia; children, adolescents, and young-adults; DTG-based regimen; elimination of paediatric AIDS; Cameroon.

Online: 5 July 2024 (12:31:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1181.v1

Intraoperative Hearing Monitoring Using ABR and TT-ECochG and Hearing Preservation during Vestibular Schwannoma Resection

Kazimierz Niemczyk, Izabela Pobożny, Robert Bartoszewicz, Krzysztof Morawski

Subject: Medicine And Pharmacology, Otolaryngology Keywords: auditory brainstem responses, acoustic neuroma, action potential, cochlear nerve, electrocochleography, hearing loss, hearing preservation, intraoperative monitoring, vestibular schwannoma

Online: 18 June 2024 (13:31:11 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1742.v1

Exploring the Potential Influence of Human Gut Microbiota on Gut Resistome: A Systematic Review

Justine Fri, Mulalo Raphalalani, Lufuno Grace Mavhandu-Ramarumo, Pascal Obong Bessong

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Gut microbiota; Gut resistome; Antibiotic resistance genes; Escherichia coli

Online: 23 July 2024 (07:25:20 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.0517.v1

Hypoxia Pathways in Parkinson’s Disease: From Pathogenesis to Therapeutic Targets

Yuanyuan Gao, Jiarui Zhang, Tuoxian Tang, Zhenjiang Liu

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Parkinson’ s disease; hypoxia; hypoxia pathways; neurodegenerative diseases; transmembrane protein 175; DJ-1; LRRK2

Online: 6 September 2024 (13:00:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0202.v1

Behavioural and Neurophysiological Assessment of Hearing Aid Benefits in an Adult Population with and without Hearing Loss

Shivali Appaiah-Konganda, Mridula Sharma, Ronny Ibrahim, Jessica J. M. Monaghan, John Newall, Joaquin Tomas Valderrama Valenzuela

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Alpha synchronisation; Working memory; Auditory processing; Modulation detection threshold

Online: 12 January 2023 (01:48:00 CET)

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Background: Despite hearing aids adequately compensate for hearing loss, a substantial proportion of the population leave their hearing difficulties untreated. Even though this is a well-known clinical issue, the optimal approach to address this issue during the hearing rehabilitation process is still unclear. Purpose: The present study aims to characterise behavioural and neurophysiological auditory and cognitive processing skills in experienced hearing aid users versus those with normal hearing, aimed at providing clinicians with the evidence required to adequately manage the expectations of their clients, thus indirectly reinforcing hearing-aid adoption within the adult population with hearing loss. Research design: Behavioural tests included auditory, cognitive, and speech-in-noise tasks; and neurophysiological testing included cortical auditory evoked potentials evoked by a /da/ stimulus presented at 65 dB SPL. The tests were selected based on previous literature supporting specific speech-understanding skills. Study sample: Ten participants (7 female, 21—68 years) with bilateral, mild-moderate to moderately-severe sensorineural hearing loss (HL), and 10 with clinically normal hearing (NH, 8 female, 19—62 years) participated in the study. Data collection and analysis: Behavioural data was analysed using multivariate analysis of variance (MANOVA) and neurophysiological analysis used measurements such as independent t-test, time-frequency analysis and inter-trial phase coherence. Results: The NH and HL groups presented similar scores in all the behavioural tasks. Time-frequency analysis revealed a statistically significantly reduction in alpha (8–12 Hz) synchronisation at the centro-frontal electrodes in the HL group – a brain activity pattern that has been associated with listening effort, inhibition and selective attention. Conclusions and significance: Results support the conclusion that hearing aids are effective in compensating for the audibility of their users, enabling them to perform at similar levels than their normal-hearing peers. However, the reduced alpha synchronisation observed in the HL population indicates that adequate audibility does not extend to improved neural responses. Future studies need to investigate the induced activity in speech understanding paradigms to explore the auditory processing differences at cortical level. The results are only from a small sample size but the findings have the potential to support clinicians in managing adequately the expectations of their clients in regards the benefits of hearing aid technologies.

Preprint ARTICLE | doi:10.20944/preprints202404.1172.v1

Sound-Evoked Neural Activity in Normal Hearing Tinnitus: The Effect of Frequency and Simulation Side

Shahin Safazadeh, Remco A Renken, Marc Thioux, Pim van Dijk

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Tinnitus; Hyperacusis; Tonotopy; Auditory cortices; Parahippocampal gyrus

Online: 17 April 2024 (14:50:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.1552.v1

Cytomegalovirus Cause Congenital Hearing Loss by Regulating the Signaling Pathways in Developing Peripheral Auditory Organ

Xiaozhou Liu, Zhengdong Zhao, Xinyu Shi, Yanjun Zong, Yu Sun

Subject: Biology And Life Sciences, Virology Keywords: virus; hearing; cytomegalovirus; development

Online: 24 June 2024 (04:09:26 CEST)

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Working Paper CONCEPT PAPER

The Hearing Impairment Ontology: A tool for unifying hearing impairment knowledge to enhance collaborative research

Jade Hotchkiss, Noluthando Manyisa, Samuel Mawuli Adadey, Oluwafemi Oluwole, Edmond Wonkam, Khuthala Mnika, Abdoulaye Yalcouye, Victoria Nembaware, Melissa Haendel, Nicole Vasilevsky, Nicola Mulder, Simon Jupp, Ambroise Wonkam, Gaston Kuzamunu Mazandu

Subject: Medicine And Pharmacology, Otolaryngology Keywords: hearing impairment; hearing loss; ontology; data harmonization; meta-analysis

Online: 19 September 2019 (11:37:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202210.0440.v1

HIV/AIDS Mathematical Model of Triangle Transmission

Cristian Camilo Espitia Morillo, João Frederico da Costa Azevedo Meyer

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: HIV/AIDS Mathematical Model; Basic Reproduction Number; Stationary Points; Local and Global Stability Analysis.

Online: 28 October 2022 (07:05:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0277.v1

Pathogenesis and Etiology of Hearing Loss in Children

Srijan Singh, Roya Huseynova, Yahya Ethawi

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Hearing loos; conductive; sensorineural; outer ear; middle ear; inner ear; SNHL; Cochlear; auditory; physical examination; history

Online: 16 August 2022 (04:04:24 CEST)

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Working Paper REVIEW

Hearing Loss and Brain Plasticity: The Hyperactivity Phenomenon

Björn Herrmann, Blake Butler

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: hearing loss; aging; hyperactivity; excitability; loss of inhibition; neurophysiology; auditory perception; neural plasticity; speech processing

Online: 15 April 2021 (13:34:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1053.v1

Comprehensive Knowledge of HIV/AIDS in Angola and Related Factors

Neida Neto Vicente Ramos, Inês Santos Estevinho Fronteira, Maria do Rosário O. Martins

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Angola; HIV; comprehensive knowledge; Health literacy; Sexuality

Online: 17 July 2023 (05:23:03 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.0392.v1

Noncoding RNA Regions: Unveiling Novel Insights into AIDS Pathogenesis

Mohammad Ahmad Ahmad Odah

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Noncoding RNA; HIV; AIDS; microRNA; Long noncoding RNA (lncRNA); Circular RNA (circRNA); HIV pathogenesis

Online: 8 March 2024 (01:54:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.1822.v1

A Situation Analysis of the Capacity of Laboratories in Zambia to Conduct Surveillance of Antimicrobial Resistance: Strengths, Weaknesses, Opportunities, and Challenges

Doreen Mainza Shempela, Steward Mudenda, Maisa Kasanga, Victor Daka, Mundia Hendrix Kangongwe, Mapeesho Kamayani, Jay Sikalima, Baron Yankonde, Cynthia Banda Kasonde, Ruth Nakazwe, Andrew Mwandila, Fatim Cham, Michael Njuguna, Bertha Simwaka, Linden Morrison, Joseph Yamweka Chizimu, John Bwalya Muma, Roma Chilengi, Karen Sichinga

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: antimicrobial resistance; bacteriology; laboratory capacity; surveillance; Zambia

Online: 28 May 2024 (09:59:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.0992.v1

Tone Decay Reconsidered: Preliminary Results of a Prospective Study in Hearing-Aid Users With Moderate to Severe Hearing Loss

Florian Herrmann Schmidt, Thomas Hocke, Lichun Zhang, Wilma Großmann, Robert Mlynski

Subject: Medicine And Pharmacology, Otolaryngology Keywords: tone decay; suprathreshold diagnostics; retrocochlear disorders; cochlear implant; hearing aid

Online: 13 December 2023 (11:28:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0255.v1

Vertical Transmission and Treatment of HIV/AIDS Epidemic with Saturation Dynamics Modeling

Zolar Francesco

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Disease, Modelling, Mathematical Solution

Online: 5 March 2024 (13:53:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202004.0493.v1

Evaluation of HIV and AIDS Workplace Policy at Nkhotakota District Council, Malawi

Patrick Mbulaje, Adamson Muula

Subject: Social Sciences, Political Science Keywords: HIV; HIV at workplace; District Implementation Plan; HIV and AIDS; Stakeholders; Funding

Online: 28 April 2020 (09:51:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.1389.v1

Gene Therapy for Inherited Hearing Loss: Updates and Chal-lenges

Roni Hahn, Karen B. Avraham

Subject: Medicine And Pharmacology, Otolaryngology Keywords: genetics; genomics; deafness; inner ear; cochlea; delivery; editing

Online: 23 October 2023 (10:52:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0840.v1

Evaluating the Health-Related Quality of Life of Transgender Living with HIV/AIDS in Lahore, Pakistan

Tahneem Yaseen, Syed Muhammad Ali, Mustansar Mehmood, Laiba Khalil, Laraib Ghouri, Malik Hammad Shaukat, Shahid Rasool

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: HIV/AIDS; HRQoL; Transgender; EQ-5D; VAS; Khuwaja Sara

Online: 13 June 2024 (10:46:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0272.v1

Attitudes of Teachers in Training Towards People With HIV/AIDS.

Aranzazú Cejudo-Cortés, Encarnación Pedrero-García, Pilar Moreno-Crespo, Olga Moreno-Fernández

Subject: Business, Economics And Management, Accounting And Taxation Keywords: HIV; AIDS; vulnerable group; young people; trainee teachers; health education

Online: 11 February 2021 (09:39:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.0665.v1

The Impact of Pause and Filler Words Encoding on Dementia Detection with Contrastive Learning

Reza Soleimani, Shengjie Guo, Katarina Haley, Adam Jacks, Edgar Lobaton

Subject: Engineering, Electrical And Electronic Engineering Keywords: Dementia; Contrastive learning; Deep learning; Text classification, LLMs, NLP

Online: 11 June 2024 (11:39:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0220.v1

Serum and Plasma miRNA Expression Levels in Sudden Sensorineural Hearing Loss

Desmond A Nunez, Reyhaneh Abgoon, Printha Wijesinghe, Cathie Garnis

Subject: Medicine And Pharmacology, Otolaryngology Keywords: Sudden Sensorineural Hearing Loss; microRNA; Serum; Plasma

Online: 5 August 2024 (03:04:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1763.v1

Correlation of Non-Auditory Comorbidities and Hearing Loss in Tinnitus Patients

Konstantin Tziridis, Benjamin Neubert, Anna Rosalie Anita Seehaus, Patrick Krauss, Achim Schilling, Petra Brüggemann, Birgit Mazurek, Holger Schulze

Subject: Medicine And Pharmacology, Otolaryngology Keywords: tinnitus; comorbidities; audiometry; retrospective patient study

Online: 1 March 2024 (08:18:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.0368.v1

Neonatal Hearing Rescreening in a Second Level Hospital: Problems and Solutions

Marta Gomez-Delgado, Jose Miguel Sequí-Sabater, Ana Marco-Sabater, Alberto Lora-Martin, Victor Aparisi-Climent, Jose Miguel Sequi-Canet

Subject: Public Health And Healthcare, Health Policy And Services Keywords: Hearing loss; neonatal hearing screening; rescreening; otoacoustic emissions; auditory potentials.

Online: 6 July 2023 (04:06:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints202008.0308.v1

A Comprehensive Review on Inherited Sensorineural Hearing Loss and Their Syndromes

Muhammad Noman, Shazia Anwer Bukhari, Muhammad Tahir, Shehbaz Ali

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Hereditary HL; genetics of syndromic and non-syndromic HL; methods for pathogenic locus/gene identification

Online: 14 August 2020 (04:45:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1005.v1

Perceived Inclusivity in Mobility Aids Use: A Qualitative Study in Iran

Mohsen Rasoulivalajoozi, Carmela Cucuzzella, Morteza Farhoudi

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: Mobility aids; Social inclusion; Physiotherapy; Inclusive design; User experiences

Online: 14 August 2024 (08:20:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.2010.v1

Aids In Spanish Penitentiary Institutions through the Nurse's Point of View

Enrique J. Vera-Remartnez, Jose Antonio Zafra Agea, Julio Garcia-Guerrero, Maria Pilar Molés-Julio

Subject: Public Health And Healthcare, Other Keywords: Síndrome de inmunodeficiencia adquirida; enfermería; prisiones; España.

Online: 1 December 2023 (10:14:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.1372.v1

Prediction Model for the Effects of Tourism on the Spread of HIV and AIDS

Ofosuhene O. Apenteng, Philip Rasmussen, Beate Conrady

Subject: Computer Science And Mathematics, Computational Mathematics Keywords: Tourism; HIV; AIDS; Malaysia, mathematical model; reproduction number; sensitivity analysis

Online: 21 August 2023 (02:30:00 CEST)

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Working Paper REVIEW

Stressor And Coping Strategies Of People Living With Hiv/aids (PlWHA): A Literature Review

Ahmad Ikhlasul Amal, Moses Glorino Rumambo Pandin

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Stressor; Coping Strategies; HIV/AIDS

Online: 16 April 2021 (09:59:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1522.v1

High Doses of Radiation Cause Cochlear Immunological Stress and Sensorineural Hearing Loss

Mengwen Shi, Huiwen Yang, Ye Wang, Chengcai Lai, Jintao Yu, Yu Sun

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Radiation; Sensorineural hearing loss; Macrophage; Cochlear Inflammation

Online: 22 January 2024 (10:08:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.0970.v1

Efficacy and Mechanisms of Antioxidant Compounds and Combinations Thereof Against Cisplatin Induced Hearing Loss in a Rat Model

L. Carles, A. Gibaja, V. Scheper, J.C. Alvarado, C. Almodovar, T.L. Lenarz, J.M. Juiz

Subject: Medicine And Pharmacology, Otolaryngology Keywords: cisplatin; ototoxicity; oxidative stress, antioxidant.

Online: 14 May 2024 (12:47:40 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202007.0541.v1

The use of Multi-compartment Compliance Aids (MCAs) in Pharmacies in England and North Wales

Ana Pedro

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: MCAs; clinical pharmacy

Online: 23 July 2020 (08:24:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1764.v1

Risk Analysis and Visualization of Merchant and Fishing Vessels Collision In Coastal Waters

Chuanguang Zhu, Jinyu Lei, Zhiyuan Wang, Decai Zheng, Chengqiang Yu, Mingzhong Chen, Wei He

Subject: Engineering, Transportation Science And Technology Keywords: Merchant and Fishing vessels collision; Coastal waters; Ship domain AIS; Data visualization

Online: 29 February 2024 (16:59:56 CET)

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Preprint REVIEW | doi:10.20944/preprints202305.0748.v1

The Pathogenesis of Cytomegalovirus and Other Viruses Associated with Hearing Loss: Recent Updates

Xinyu Shi, Xiaozhou Liu, Yu Sun

Subject: Biology And Life Sciences, Virology Keywords: cytomegalovirus; hearing loss; pathogenesis

Online: 10 May 2023 (11:20:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0103.v1

Keypoints to a Successful Newborn Hearing Screening. Thirty Years of Experience and Innovations

Jose Miguel Sequi Canet, Juan Brines Solanes

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Neonatal hearing screening; Otoacoustic emissions; Deafness; Newborn screening.

Online: 6 September 2021 (13:57:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1082.v1

Experiences of Hearing Parents of Deaf Children; A Qualitative Study

Gül Dikeç, Eda Türk, Esin Yüksel, Kübra Çelebi, Meltem Özdemir

Subject: Public Health And Healthcare, Nursing Keywords: child; deafness; parents; qualitative research.

Online: 15 June 2023 (07:29:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201912.0417.v1

Designing Internet of Things Tangibles for Children with Hearing Disability

Sandra Cano, Victor Peñeñory, César A. Collazos, Sergio Albiol

Subject: Engineering, Mechanical Engineering Keywords: tangible interfaces; Internet of Things tangibles; children with hearing impairment

Online: 31 December 2019 (16:48:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1175.v1

Salivary And Urine Metabomic Profile Of Patients Living With Hiv/aids, And Its Association With Periodontal Disease

Viviane Balero Cosse De Sousa, Wagner Santos e Santos, Matheus Rigo Ribeiro, Gabriel Casemiro Quicoli, Juliana Silva, Guilherme Pires Cardoso, Caio Paulino Laporta, Maria Anita Mendes, Meriellen Dias, Ruth Andia Merlin, Bruno Vieira Caputo, Gilberto Araújo Noro Filho, Michael Bredos Arseniam, Kelly Cristine Tarquínio Marinho, Levy Anderson César Alves, Elcio Magdalena Giovani

Subject: Public Health And Healthcare, Other Keywords: Metabolô; mica; Biofluidos; Metabó; litos; Biomarcadores; HIV.

Online: 19 March 2024 (16:32:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.1596.v1

Estimating Monetary Demand Using a Flexible Model of Almost Ideal Demand System(AIDS)

Jafar Azizi, Afsaneh Jabbari

Subject: Business, Economics And Management, Economics Keywords: Monetary demand function; AIDS; price and non-price elasticity

Online: 24 June 2024 (08:43:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0141.v1

Molecular Identification of Cryptosporidium spp. in Patients Living with HIV / AIDS in Honduras

Sergio Betancourth, Osman Archaga, Wendy Moncada, Vilma Rodríguez, Gustavo Fontecha

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Cryptosporidium spp; C. parvum; gp60; 18S ribosomal; cowp; HIV / AIDS; Honduras

Online: 4 February 2021 (14:42:28 CET)

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Preprint REVIEW | doi:10.20944/preprints202302.0321.v1

Application of Human Stem Cells to Model Genetic Sensorineural Hearing Loss and Meniere Disease

Mar Lamolda, Lidia Frejo, Alvaro Gallego-Martinez, Jose Antonio Lopez-Escamez

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: human induced pluripotent stem cells; inner ear disorders; disease modeling; sensorineural hearing loss; Meniere disease; biomedical applications

Online: 20 February 2023 (06:17:44 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.0817.v1

Hearing Rehabilitation in Single Side Deafness: CROS vs BCD vs CI

Alessandra Pantaleo, Alessandra Murri, Giada Cavallaro, Vito Pontillo, Nicola Quaranta

Subject: Medicine And Pharmacology, Otolaryngology Keywords: Single-sided deafness (SSD); cochlear implants (CI); contra-lateral-routing-of-signal (CROS) devices; bone conduction devices (BCD)

Online: 13 November 2023 (11:38:36 CET)

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Preprint REVIEW | doi:10.20944/preprints201901.0039.v1

Prevention of Hearing Loss by Alteration of the Systemic Immune System

Hiroshi Iwai, Muneo Inaba

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: autoimmune sensorineural hearing loss; age-related sensorineural hearing loss; inflammation, immune senescence; interleukin 1 receptor type II -positive T cells; naturally occurring regulatory T cells; immune rejuvenation; thymus

Online: 4 January 2019 (11:37:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.1828.v1

Wastewater Surveillance of SARS-CoV-2 in Zambia: An Early Warning Tool

Doreen Mainza Shempela, Walter Muleya, Steward Mudenda, Victor Daka, Jay Sikalima, Mapeesho Kamayani, Dickson Sandala, Chilufya Chipango, Kapina Muzala, Kunda Musonda, Joseph Yamweka Chizimu, Chilufya Mulenga, Otridah Kapona, Geoffrey Kwenda, Maisa Kasanga, Michael Njuguna, Fatim Cham, Bertha Simwaka, Linden Morrison, John Bwalya Muma, Ngonda Saasa, Karen Sichinga, Edgar Simulundu, Roma Chilengi

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Wastewater; Surveillance; Early warning; SARS-CoV-2; COVID-19; Zambia

Online: 26 June 2024 (06:05:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201710.0056.v1

Conditioning Factors in the Transition Process to the Self-Care of Women with AIDS

Claudia Regina de Andrade Arrais Rosa, Simony Fabíola Lopes Nunes, Regiane Silva de Jesus, Francisco Dimitre Rodrigo Pereira Santos, Leila Rute Oliveira Gurgel do Amaral, Nilviane Pires Silva Sousa, Daniel Costa Duarte, Allan Kardec Barros Duailibe Filho

Subject: Social Sciences, Psychology Keywords: nursing theory; self-care women; HIV

Online: 10 October 2017 (02:55:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0263.v1

Working Memory and Language Relate to Report of Socioemotional Functioning in Children with Hearing Loss

Dorothy A. White, Elizabeth Adams Costa, Nancy Mellon, Meredith Ouellette, Sharlene Wilson Ottley

Subject: Social Sciences, Psychology Keywords: Hearing Loss; Childhood; Working Memory; Language; Socioemotional

Online: 5 February 2024 (15:23:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0459.v1

Sociodemographic and Clinical Predictors of Health Insurance Coverage among Patients Seeking Viral Hepatitis B and C Services in Nigeria: A Cross-Sectional Facility-Based Study

Abiola Victor Adepoju, Donald C Udah, Chinonye Ezenwa Alioha, Jamiyu Ganiyu, Sumaiya Muhammad Lawal, James Ambo Haruna, Ibrahim Adamu Alhassan

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Health insurance; Nigeria; Universal health Coverage; Sociodemographic predictors; Viral hepatitis B and C;

Online: 8 February 2024 (08:15:43 CET)

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Abstract: Background: Viral hepatitis B and C (HBV and HCV) pose significant public health challenges globally, particularly in Nigeria, where access to healthcare and treatment affordability are major concerns. This study aims to identify sociodemographic and clinical predictors of health insurance coverage among patients with HBV and HCV in Nigeria. Methods: A cross-sectional facility-based study was conducted at two secondary hospitals in Nasarawa State, Nigeria. Par-ticipants included patients diagnosed with HBV, HCV, or both and are > 18 years old. Data were collected using a structured questionnaire covering sociodemographic and clinical information, health insurance details, and economic impact. Logistic multivariate regression analysis was used to analyze the relationship between sociodemographic/clinical variables and health insurance status. Results: Out of 295 participants included in the final analysis, 67.1% had health insur-ance, primarily covering hepatitis screening and vaccination. Being aged 31-45 years (adjusted Odds Ratio [aOR]: 5.72, 95% Confidence Interval [CI]: 1.4 - 23.28, p = 0.02), having post-secondary education (aOR: 11.73, CI: 4.09 - 33.66, p < 0.001), and being HIV-positive (aOR: 2.86, CI: 1.02 - 8.02, p = 0.046) were significant predictors of health insurance coverage. Being unemployed significantly reduced the likelihood of having health insurance (aOR: 0.04, CI: 0.01 - 0.11, p < 0.001).Conclusions: This study reveals high insurance coverage among patients seeking viral hepatitis services in Nasarawa state, Nigeria and provides critical insights into the sociodemo-graphic predictors of health insurance coverage. It also highlights the need for the expansion health insurance benefit package that covers for viral hepatitis diagnosis and treatment, espe-cially for the younger adults, unemployed and less educated populations. This should be followed with adequate budgeting and policy implementation monitoring efforts, which are crucial for Nigeria's journey towards universal health coverage and elimination of viral hepatitis.

Preprint ARTICLE | doi:10.20944/preprints202211.0047.v1

Overcoming the Language Barrier in Hearing-Speech Rehabilitation Using Multilingual Conversational Applications

Wiebke Rötz, Theda Eichler, Rayoung Kim, Holger Sudhoff, Ingo Todt

Subject: Medicine And Pharmacology, Otolaryngology Keywords: hearing therpy; speech therapy; cochlea implant; digital application

Online: 2 November 2022 (06:10:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202207.0098.v1

Analysis of Confirmatory Auditory Responses in Unilateral Tinnitus Patients with Normal Hearing

Yong Jun Jeong, Kyoung Ho Oh, Sung Jin Lim, Dong Heun Park, Yoon Chan Rah, June Choi

Subject: Medicine And Pharmacology, Otolaryngology Keywords: tinnitus; normal hearing; Evoked potentials; auditory; brain stem; otoacoustic emission

Online: 6 July 2022 (13:54:44 CEST)

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In patients with unilateral tinnitus with normal hearing, several studies have compared the ipsilateral and contralateral ears; however, few studies have investigated its relationship with the duration of tinnitus. We compared the auditory brainstem response and otoacoustic emission parameters between ipsilateral and contralateral ears in adults with unilateral tinnitus and normal hearing. This retrospective review included 84 patients with unilateral tinnitus and normal hearing who underwent auditory brainstem response and otoacoustic emission; they were categorized according to the duration of tinnitus. The latencies and amplitudes of waves I, III, and V, and V/I ratio of both ears in auditory brainstem response, and the results of distortion-product otoacoustic emission and transient evoked otoacoustic emission were examined. The auditory brainstem response parameters, distortion-product otoacoustic emission parameters, and transient evoked otoacoustic emission parameters between the ipsilateral and contralateral ears along the duration of tinnitus were analyzed. Moreover, the failure rates of both distortion-product otoacoustic emission and transient evoked otoacoustic emission between the ears along with the duration and the effects of the variables on the amplitude and latency of each wave were examined. Although there was little significant difference between the ipsilateral and contralateral ears, laterality seemed to have an effect on wave I latency in the multiple linear regression analysis. The distortion-product otoacoustic emission failure rate of the ipsilateral ear was higher than that of the contralateral ear in all patients. However, there was no remarkable difference between the ears in the distortion-product otoacoustic emission and transient evoked otoacoustic emission parameters throughout the duration. We found that outer hair cells and the distal portion of the cochlear nerve are possible pathologic lesions in tinnitus with normal hearing and cochlear synaptopathy could be suspected. Further studies, including those on inner hair cells and higher central cortex, are needed.

Preprint REVIEW | doi:10.20944/preprints202101.0099.v1

Zebrafish as a Biomedical Model for Stem Cells Research in Hearing Impairment

Salma Hafeez

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: biomedical model; hearing impairment; regeneration; stem cells; zebrafish

Online: 5 January 2021 (14:23:23 CET)

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Preprint REVIEW | doi:10.20944/preprints201909.0222.v1

Elucidating Biological Roles of Novel Murine Genes in Hearing Impairment in Africa

Oluwafemi Oluwole, Abdoulaye Yalcouye, Edmond Wonkam, Noluthando Manyisa, Jack Morrice, Gaston Mazanda, Ambroise Wonkam

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: hearing impairment; novel murine genes; gene enrichment; africa

Online: 19 September 2019 (11:27:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0898.v1

HIV/AIDS-Associated Knowledge and Attitudes Towards Treating Disadvantaged Communities among Pre-CBDE Dental Students in the U.S.

Aditi Tomar, Hannah Balcezak, Shirley Lewis Miranda, Marie C Latortue, Richa Chinchkhandi, Lisa Wigfall

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: HIV/AIDS; community‐based dental education (CBDE); people living with HIV/AIDS (PLWHA)

Online: 14 May 2024 (11:09:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0504.v1

Influence of HIV/AIDS infection on Immunological and Nutritional Status. A Cross Sectional Study in Kingdom of Bahrain

Fatima Alabdulali, Afnan Freije, Mariam Al-Mannai, Jameela Alsalman, Fatima Buabbas, Mariangela Rondanelli, Simone Perna

Subject: Biology And Life Sciences, Virology Keywords: HIV/AIDS patients; Nutritional; biochemical; Markers; immunological disease

Online: 8 May 2023 (10:10:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0483.v1

Hepatitis B Virus Prevalence Among HIV-Uninfected People Living in Rural and Peri-Urban Areas in Botswana

Motswedi Anderson, Thabo Mangogola, Bonolo B. Phinius, Gorata Mpebe, Christopher O. Aimakhu, Wonderful T. Choga, Basetsana Phakedi, Lynnette N. Bhebhe, Doreen Ditshwanelo, Kabo Baruti, Linda Mpofu-Dobo, Lebogang Othusitse, Tsholofelo Ratsoma, Tendani Gaolathe, Joseph Makhema, Roger Shapiro, Shahin Lockman, Sikhulile Moyo, Simani Gaseitsiwe

Subject: Biology And Life Sciences, Virology Keywords: Hepatitis B Virus; HBV; prevalence; genotypes; mutations; HIV negative; Africa

Online: 8 May 2024 (07:19:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0517.v1

Hearing Assistive Technology Facilitates Sentence-in-Noise Recognition in Children with Autism Spectrum Disorder

Suyun Xu, Juan Fan, Hua Zhang, Minyue Zhang, Hang Zhao, Xiaoming Jiang, Hongwei Ding, Yang Zhang

Subject: Biology And Life Sciences, Behavioral Sciences Keywords: Autism spectrum disorder; Auditory stream segregation; Hearing assistive technology; Speech-in-noise perception; Tonal language speakers

Online: 30 March 2023 (02:52:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0167.v1

Elucidating the Causal Link Between Hearing and Chronic Kidney Disease Through Mendelian Randomization and Development of Predictive Machine Learning Models Based on NHANES Data

Yanting Yang, Yuqing Li, Zhongquan Huang, Rongrong Lin, Zhuoni Chen, Ning Zhang, Nan Zheng, Jiean Xu, Yaqi Zhou

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Chronic kidney disease; Hearing; Mendelian randomization; Machine learning models; Predictions

Online: 2 August 2024 (10:56:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1260.v1

Pharmacological Modulation of Energy and Metabolic Pathways Protects Hearing in the Fus1 KO Model of Mitochondrial Dysfunction and Oxidative Stress

Winston JT Tan, Joseph Santos-Sacchi, Jane Tonello, Anil Shanker, Alla V Ivanova

Subject: Biology And Life Sciences, Aging Keywords: Age-related hearing loss; cochlea; Fus1/Tusc2; mitochondria; mitochondrial dysfunction; oxidative stress; 2-deoxy-D-glucose; Rapamycin; Seahorse Metabolism Analysis

Online: 18 May 2023 (02:25:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0246.v1

Regional Health Divides: Understanding Inequities in Late Diagnosis of HIV in Tajikistan

Kamiar Alaei, Brian Kwan, Hamid R. Torabzadeh, Adebimpe O. Akinwalere, Sattorov S. Saydamirovich, Gafur Mohsinzoda, Arash Alaei

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: HIV detection; HIV testing; Tajikistan; Central Asia; regional disparities; rural areas; gender disparities; age; COVID-19; case study

Online: 5 March 2024 (10:51:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0793.v1

A Wearable Assistant Device for Hearing Impaired to Recognize Emergency Vehicle Sirens with Edge Computing

Chiun-Li Chin, Chia-Chun Lin, Jing-Wen Wang, Wei-Cheng Chin, Yu-Hsiang Chen, Sheng-Wen Chang, Pei-Chen Huang, Xin Zhu, Yu-Lun Hsu, Shing-Hong Liu

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: edge computing; human vocalization; emergence vehicle siren; EfficientNet-based; fuzzy rank-based ensemble model; hearing impairment.

Online: 9 August 2023 (15:18:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.2164.v1

Regional Profiling for the Frequency, Patterns, and Factors of Hearing Loss Reveals Genetics, Geriatric Age, and Noise Hazard as Major Predispositions

Abdullah D.Alotaibi, Kamaleldin B Said, Ruba M. Elsaid Ahmed, Mona . S. Alonazi, Bassam E. Alshammari, Lama B. Abdulkarim, Amal A. Al-Otaibi, Bashayr N. Alsuwayt, Wafi Abdulrahman Alrashidi, Razan S Alsubaie, Manar A ALGhaslan

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Hearing impairment; ENT diseases; surveillance of ear problems

Online: 31 May 2024 (14:28:57 CEST)

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Hearing loss (HL) is a major clinical, population and public health leading to serious disorders and often early mortality. However, there is a significant paucity in high quality data. Saudi Arabia has a genetically uniform and young population; however factors and estimates on prevalence of HL remains unknown. Background/Objectives: we aimed to determine the frequency, factors, and patterns of HL in different regions. Methods: this study was a descriptive cross-sectional design using a web-based online public questionnaire sent out simultaneously to different regions of Saudi Arabia; namely Eastern, Western, Northen, and Southern as self-administered non-probability sample of social media users mainly WhatsApp, Twitter, and others. Results: Among 789 responses, 6.6 % reported HL, 62.4% were from the Eastern province of which 41.2% were employed and 31.7% were students. Many (36.5%) reported HL > 5-years while 21.2% had programmed and fitted with hearing aids or cochlear implants implying negligence. 19.2% reported diabetes and 51.9% had family history. Ages (11– 50 years) were examined with a slight female predominance (females 59.1%, males 41%). Age was significantly associated with HL (P <0.001) irrespective of gender (males 6.8%, females 6.4%, P value =0.838) reaching peaks at 17.2% in age groups 51-60 years and 25% in 71-80 indicating a risk for HL (OR = 1.43, 95% CI: 0.78-2.81, p = 0.032). Genetic diseases reported as leading cause in 34.6% (OR = 2.23, 95% CI: 1.34-3.58, p = 0.432) followed by noise (26.9%), while other factors including infections, stroke, and fevers made 19.2%. Work involving air or sea travels reported (7.7%) with no significant association (P = 0.628) while history of head injury or trauma (11.5%), or relocation between low- and high-altitudes showed 21.2%. However, frequent noise pollution (OR = 1.54, 95% CI: 0.83-3.01, p = 0.048), regular use of medications (OR = 2.15, 95% CI: 1.03-3.32, p = 0.017), and history of inflammatory disorders (OR = 0.72, 95% CI: 0.32-1.87, p = 0.229) were also associated with higher odds of HL. Conclusion: thus, these findings have significant clinical implications in early diagnosis and management of HL in genetic disorders, diabetes, geriatrics, as well as awareness on family history and occupational health and safety. The study was limited in size and use of online questionnaires. Future large cohort multicenter study would gain more insights.

Preprint ARTICLE | doi:10.20944/preprints202309.1710.v1

Genotypic and Allelic Frequencies of GJB2 Variants and Features of Hearing Phenotypes in the Chinese Population of the Dongfeng-Tongji Cohort

Lanlai Yuan, Xiaohui Wang, Xiaozhou Liu, Sen Chen, Weijia Kong, Meian He, Yu Sun

Subject: Medicine And Pharmacology, Otolaryngology Keywords: hearing loss; GJB2 variants; p.V37I; c.235delC; audiogram shapes

Online: 26 September 2023 (13:51:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0666.v1

They Have Always Called Us Sick: Heterosexism and Medical Inequality for Queer Americans with Chronic Illness and a Potential New Direction for AIDS Discourses

B. Garrick Harden, Andre A. Favors

Subject: Social Sciences, Sociology Keywords: Queer Theory; Pandemics; Sexuality; AIDS Discourses; COVID Discourses

Online: 9 January 2024 (10:30:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.0355.v1

X-linked Gusher Disease DFNX2 in Children, a Rare Inner Ear Dysplasia with Conductive Hearing Loss

Soumit Dasgupta, James Hong, Rhyanna Morris, Javed Iqbal, Amy Lennox, Jeyasakthy Saniasiaya

Subject: Medicine And Pharmacology, Otolaryngology Keywords: Third window; X-linked gusher; hearing loss; audiovestibular; POU3F4

Online: 6 July 2023 (09:16:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0051.v1

AI-based Detection of Aspiration for Video-endoscopy with Visual Aids in Meaningful Frames to Interpret the Model Outcome

Jürgen Konradi, Milla Zajber, Ullrich Betz, Philipp Drees, Annika Gerken, Hans Meine

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: XAI; segmentation; detection; aspiration; glottis; vocal cords; endoscopy; FEES; interpretability; meaningful sequences; key frames

Online: 2 December 2022 (12:22:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.1819.v1

Regional Profiling for the Frequency, Patterns, and Factors of Hearing Loss Reveals, Geriatric Age, Noise, and Inheritance History as Major Potential Predispositions

Abdullah D. Alotaibi1, Kamaledin B Said, Abdelhafiz I. Bashir, Ruba M. Elsaid Ahmed, Mona S. Alonazi, Bassam E. Alshammar, Lama B. Abdulkarim, Amal S. Al-Otaibi, Bashayr N. Alsuwayt, Wafi A. Alrashidi, Razan S. Sultan Alsubaie, Manar A. ALGhaslan, Arwa A Alotaibi, Mohammad S. Alzughaibi, Fahad M. Alshammary, Salem A. Almijrad, Anwar E. Almallahi

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Hearing impairment; ENT diseases; surveillance of ear problems, factors of hearing loss, regional influence in HL

Online: 23 September 2024 (16:44:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0505.v1

Induced Short-term Hearing Loss due to Stimulation of Age-related Factors by Intermittent Hypoxia, High-Fat Diet, and Galactose Injection

Dong Jun Park, Sunmok Ha, Jin Sil Choi, Su Hoon Lee, Jeong-Eun Park, Young Joon Seo

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: mitochondria dysfunction; reactive oxygen species; hypoxic; D-galactose; high fat diet; aging; hearing loss; mechanisms of hearing loss

Online: 22 July 2020 (07:58:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1335.v1

Factors Associated with Late Diagnosis of HIV/AIDS in a University Hospital in Brazil: Challenges to Achieving the 2030 Target

Ligia Maria Nascimento Arantes, Andrey Oeiras Pedroso, Mayra Gonçalves Menegueti, Elucir Gir, Eliã Pinheiro Botelho, Ana Cristina de Oliveira e Silva, Renata Karina Reis

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: HIV; Acquired Immunodeficiency Syndrome; late diagnosis; Nursing

Online: 19 July 2023 (11:40:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202011.0442.v1

Oral Antioxidant Vitamins and Magnesium Limit Noise-induced Hearing Loss by Promoting Sensory Hair Cell Survival: Role of Antioxidant Enzymes and Apoptosis Genes

Juan C Alvarado, Veronica Fuentes-Santamaría, Pedro Melgar-Rojas, Maria C Gabaldon-Ull, Jose J Cabanes-Sanchis, Jose M Juiz

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: auditory; deafness; acoustic trauma; hair cells; antioxidant; otoprotection

Online: 17 November 2020 (09:40:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1157.v1

Bluetooth Noise-Canceling Headphones Improve the Quality of Ophthalmic Exam in Hearing-Loss Patients – A Randomized Controlled Trial

Benjamin M. Glanzer, Malik S Ladki, Metha Chea, Lena Hummel, Brian McKinnon, Biai Dominique Elmir Digbeu, Kevin H. Merkley, Atish S Amin, Praveena K Gupta

Subject: Medicine And Pharmacology, Ophthalmology Keywords: Hearing-loss; headphones; noise-canceling; communication; elderly; Bluetooth; ophthalmic exam

Online: 18 October 2023 (17:22:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0048.v1

Design of Educational Tools Based on Traditional Games for the Improvement of Social and Personal Skills of Primary School Students with Hearing Impairment

Jesús Fernández-Gavira, Paola Espada-Goya, Virginia Alcaraz-Rodríguez, David Moscoso-Sánchez

Subject: Social Sciences, Education Keywords: information technologies (I.T); sign language; hearing impairment; traditional games; primary school teaching; inclusive education; physical education

Online: 2 November 2021 (11:54:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.0082.v1

Challenges of Tuberculosis Screening and Existing Gaps in Contact Investigations in Oyo and Osun States, Nigeria

Aderonke Agbaje, Patrick Dakum, Olugbenga Daniel, Anyaike Chukwuma, Obioma Chijoke-Akaniro, Evaezi Okpokoro, Samuel Akingbesote, Christian Anyomi, Adekola Adekunle, Abiola Alege, Moroof Gbadamosi, Olutunde Babalola, Mensah Charles, Rupert Eneogu, Austin Ihesie, Debby Nongo, Ademola Adelekan

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Tuberculosis; Contact investigation; Challenges; Existing gaps

Online: 1 May 2024 (16:47:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0502.v1

Stem Cell Differentiation Stage Factors (SCDSFs) Taken from Zebrafish Embryo During Organogenesis and Their Role as Epigenetics Regulators Able to Reverse Neurosensory Hearing Loss

Pier Mario Biava, Stefano Ciaurelli, Riccardo Benzi Cibelli, Gianpaolo Pisano

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Stem Cell; Embryo; Zebrafish; Neurosensory Hearing Loss; Tissue Regeneration

Online: 26 November 2021 (10:52:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0422.v1

Occupational Noise Induced Hearing Loss in the Mining Sector in South Africa: How Are Mineworkers Trained—Perspective from Occupational Health Personnels

Nomfundo Moroe

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: awareness; education; hearing loss; mineworkers; occupational health; health literacy; audiologists

Online: 18 October 2018 (12:04:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1615.v1

Effectiveness of Hepatitis C Virus Self-Testing Service Delivery Models among People Who Inject Drugs: A Cross-Sectional Study in Vietnam

Bao Ngoc Vu, Kimberly Elizabeth Green, Minh Hung Tran, Huong Mai Nguyen, Kim Tuan Do, Khoa Trong Nguyen, Huong Thi Thu Phan, Lien Thi Huong Tran, An Khanh Tran, Giang Thu Le, Chau Van Pham, Krista Granger, An Le Thanh Nguyen, Long Khanh Tran

Subject: Public Health And Healthcare, Primary Health Care Keywords: HCV self-testing; people who inject drugs; effectiveness; service delivery; Vietnam

Online: 19 July 2024 (15:19:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1768.v1

Implementation of Portable Digital Chest X-Ray Machine for Tuberculosis Contact Tracing in Oyo and Osun States, Nigeria: A Formative Assessment

Aderonke Agbaje, Patrick Dakum, Olugbenga Daniel, Anyaike Chukwuma, Obioma Chijoke-Akaniro, Evaezi Okpokoro, Samuel Akingbesote, Christian Anyomi, Adekola Adekunle, Abiola Alege, Moroof Gbadamosi, Olutunde Babalola, Mensah Charles, Rupert Eneogu, Austin Ihesie, Debby Nongo, Ademola Adelekan

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Keywords Tuberculosis; Contact investigations; Portable X-ray machine

Online: 27 May 2024 (14:28:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0130.v2

Delving into Hearing Threshold of the Delay Gap of Initial Reflection in a Room by Using the Response of Cortical Brain Waves

Chiung Yao Chen

Subject: Environmental And Earth Sciences, Environmental Science Keywords: initial time delay gap; just noticeable difference; autocorrection function; continuous brainwaves

Online: 6 September 2023 (10:23:14 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202408.0215.v1

Successful Extracorporeal Membrane Oxygenation Treatment in a Newly Diagnosed HIV Positive and Acquired Immune Defi-Ciency Syndrome (Aids) Patient with Acute Respiratory Distress Syndrome (Ards) Complicated by Pneumocystis and Cytomeg-Alovirus Pneumo

Jin Kook Kang, Matthew Acton, Bo Soo Kim

Subject: Medicine And Pharmacology, Surgery Keywords: VV-ECMO; ARDS; HIV; AIDS; PJP; CMV; ART

Online: 5 August 2024 (09:31:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1059.v1

Cross-cultural Adaptation and Validation of the Listening Inventory for Education-Revised in Italian

Maria Nicastri, Hilal Dincer D’Alessandro, Karen Anderson, Miriana Ciferri, Luca Cavalcanti, Antonio Greco, Ilaria Giallini, Ginevra Portanova, Patrizia Mancini

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: children; hearing loss; classroom performance; acoustics; cochlear implants; LIFE-R; mainstream education

Online: 14 August 2024 (11:57:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1770.v1

Screening for Latent Tuberculosis Infection in People Living with HIV: TUBHIVIT Project, a Multicentre Italian Study

Luca Pipitò, Elena Delfina Ricci, Paolo Maggi, Giuseppe Vittorio De Socio, Giovanni Francesco Pellicano, Marcello Trizzino, Raffaella Rubino, Alessandra Lanzi, Lorenzo Crupi, Ilaria Capriglione, Nicola Squillace, Giuseppe Nunnari, Antonio Di Biagio, Paolo Bonfanti, Antonio Cascio

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Tuberculosis; HIV; latent tuberculosis; TB; LTBI

Online: 26 April 2024 (20:02:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1779.v1

An Exuberant Case of Ulceronodular-Rupioid (Malignant) Syphilis in an HIV Patient. A Proposal for New Diagnostic Criteria

Dennys Jimenez, Marian Santillan Rabe, Apeksha N. Agarwal, Scott R. Dalton, Gregory M Anstead

Subject: Medicine And Pharmacology, Dermatology Keywords: malignant syphilis; human immunodeficiency virus; lues maligna; Treponema pallidum; ulceronodular syphilis; rupioid syphilis

Online: 26 April 2024 (19:34:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1815.v1

An Integrated Approach Based on Clinical Data Together with Metabolites and Biomarkers for the Assessment of the Postoperative Complications after Cardiac Surgery

Peter Meinarovich, Alisa Pautova, Evgenii Zuev, Ekaterina Sorokina, Ekaterina Chernevskaya, Natalia Beloborodova

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: aromatic microbial metabolites; sepsis-associated metabolites; 4-hydroxyphenyllactic acid; prognostic models; SOFA

Online: 23 July 2024 (16:04:39 CEST)

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Background: Early diagnosis of postoperative complications is an urgent task, allowing timely prescribing of appropriate therapy and reducing the cost of patient treatment. Prognostic models based on various data could help in the early diagnosis of postoperative complications after cardiac surgery. Objectives: The purpose of the study was to determine whether an integrated approach based on clinical data along with metabolites and biomarkers had greater predictive value than the models built on less data. Methods: The study included patients (n=62) admitted for planned cardiac surgery (coronary artery bypass grafting with cardiopulmonary bypass), who were retrospectively divided into two groups depending on the presence (n=26) or absence (n=36) of postoperative complications of all types. Clinical and laboratory data on the first day after surgery were analyzed. Additionally, patients' blood samples were collected before and on the first day after surgery to determine biomarkers (interleukin-6, procalcitonin, NT-proBNP, high-sensitivity troponin T) and metabolites (8 aromatic and 2 dicarboxylic acids were detected using gas chromatography-mass spectrometry). Results: Patients before surgery, compared with healthy donors, differed in the concentration of metabolites (p < 0.05), and had concentrations of a number of biomarkers exceeding the corresponding reference values. Multivariate PLS-DA models, predicting the presence or absence of postoperative complications, were built using clinical data (ROC-AUC=0.71), concentrations of metabolites and biomarkers (ROC-AUC=0.60), and the entire data set (ROC-AUC=0.75). For comparison we built univariate models using the EuroScore2 (ROC-AUC=0.59) and SOFA (ROC-AUC=0.76) scales; concentrations of lactate (ROC-AUC=0.71), the dynamic changes of 4-hydroxyphenyllactic acid (ROC-AUC=0.69), and the sum of three sepsis-associated metabolites (ROC-AUC=0.70). The proposed complex model using entire data set was comparable to the SOFA scale, which confirms the expediency of searching for new predictive models based on a variety of factors.

Preprint REVIEW | doi:10.20944/preprints202406.0540.v1

Whey as an Optimal Substrate for the Development of Functional Products Enriched with Bioactive Peptides

Margarita Saubenova, Yelena Oleinikova, Alexander Rapoport, Sviatoslav Maksimovich, Zhanerke Yermekbay, Elana Khamedova

Subject: Biology And Life Sciences, Food Science And Technology Keywords: functional products; peptides, whey; fermentation; lactic acid bacteria; proteolytic activity.

Online: 10 June 2024 (08:49:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1023.v1

A Contribution to the Integration of International, National and Local Cultural Heritage Protection through a Multilevel Approach to Planning: A Case Study of the Djerdap Area

Ana Niković, Božidar Manić, Nataša Čolić Marković, Nikola Krunić

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Djerdap; Danube; spatial plan; protected area; cultural heritage; multilevel approach

Online: 16 April 2024 (10:27:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1356.v1

Impact of Southerly Surge on Rainfall Pattern Over Java, Bali, West Nusa Tenggara and East Nusa Tenggara during Asian Winter Monsoon and Its Relationship to MJO Condition

Trismidianto Trismidianto, Didi Satiadi, Wendi Harjupa, Ibnu Fathrio, Risyanto Risyanto, Elfira Saufina, Robi Muharsyah, Danang Eko Nuryanto, Fadli Nauval, Dita Fatria Andarini, Anis Purwaningsih, Teguh Harjana, Alfan Sukmana Praja, Adi Witono, Ina Juaeni, Bambang Suhandi

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Southerly Surge; MJO; Rainfall; Java Island; East Nusa Tenggara

Online: 19 June 2024 (14:10:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1950.v1

A Lightweight and High-Precision Passion Fruit YOLO Detection Model for Deployment in Embedded Devices

Qiyan Sun, Pengbo Li, Chentao He, QiMing Song, Zhicong Luo

Subject: Engineering, Electrical And Electronic Engineering Keywords: passion fruit detection; lightweight; deep learning; knowledge distillation; embedded devices

Online: 29 May 2024 (14:12:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1484.v1

Assessment of SLAM Scanner Accuracy for Outdoor and Indoor Surveying Tasks

Zahra Gharineiat, Fayez Tarsha Kurdi, Krish Henny, Hamish Gray, Aaron Jamieson, Nicholas Reeves

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: SLAM; LiDAR; accuracy assessment; indoor and outdoor; data acquisition

Online: 23 April 2024 (11:59:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2202.v1

CSA-SA-CRTNN: A Dual-Stream Adaptive Convolutional Cyclic Hybrid Network Combining Attention Mechanisms for EEG Emotion Recognition

Ren Qian, Xin Xiong, Jianhua Zhou, Hongde Yu, Kaiwen Sha

Subject: Biology And Life Sciences, Behavioral Sciences Keywords: EEG; emotion recognition; attention mechanism; Dual-Stream model; adaptive; hybrid network

Online: 29 July 2024 (10:43:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0276.v1

Methylation-GC-MS/FID-Based Glycosidic Linkage Analysis of Unfractionated Polysaccharides in Red Seaweeds

Barinder Bajwa, Xiaohui Xing, Stephanie A. Terry, Robert J. Gruninger, D. Wade Abbott

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: methylation analysis; reductive hydrolysis; whole food fiber; whole cell wall; anhydro sugar; agarose; carrageenan; sulfated galactan; mixed linkage xylan; principal component analysis

Online: 3 April 2024 (10:33:21 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202402.1644.v2

The Impact of an Online Sleep Education Program (Sleep 101) on Sleep Hygiene and Sleep Behavior in College Students

Johanna Schmickler, Rebecca Robbins, Pallas Snider Ziporyn, Stuart Quan

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: sleep hygiene; sleep behavior; college students; sleep education program

Online: 6 March 2024 (04:49:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0476.v1

Metabolomics on Apple (Malus domestica) Cuticle—Search for Authenticity Markers

Kamila Bechynska, Jiri Sedlak, Leos Uttl, Vit Kosek, Petra Vackova, Vladimir Kocourek, Jana Hajslova

Subject: Chemistry And Materials Science, Food Chemistry Keywords: Malus domestica; apple cuticle; UHPLC-HRMS/MS; metabolomic fingerprints; classification models; markers; wax esters

Online: 8 April 2024 (03:04:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1783.v1

Quantitative Trait Loci Mapping and Candidate Gene Analysis for Fiber Quality Traits in Upland Cotton

Xiaoyun Jia, Hongxia Zhao, Jijie Zhu, Hantao Wang, Shijie Wang, Miao Li, Guoyin Wang

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: upland cotton; fiber quality; QTL mapping; candidate gene; qRT-PCR

Online: 25 June 2024 (15:12:46 CEST)

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Superior fiber quality is one of the most important objectives in cotton breeding. To detect the genetic basis underlying fiber quality, an F2 population containing 413 plants was constructed by crossing Jifeng 914 and Jifeng 173, both of which have superior fiber quality, with Jifeng 173 being better. Five fiber quality traits were investigated in the F2, F2:3, F2:4, and F2:5 populations. Quantitative trait loci (QTL) mapping was conducted based on a high-density genetic map containing 11,488 single nucleotide polymorphisms (SNPs) and spanning 4,202.12 cM in length. Transgressive segregation patterns and complex correlations in the five tested traits were observed. A total of 108 QTLs were found, including 27 for fiber length (FL), 16 for fiber strength (FS), 24 for micronaire (MC), 17 for fiber uniformity (FU), and 24 for fiber elongation rate (FE). Chromosome A7 contained 12 QTL, ranking the first. No QTL was found on chromosome D1 and D11. Each QTL contributed 1.98%–21.45% to the phenotypic variation (PV), including 13 major effect QTLs that contributed more than 10% toward PV. Two QTLs could be repeatedly detected in three populations, including qFL-D3-2 in F2, F2:4, and F2:5 with 9.18%–21.45% of PV, qFS-A11-1 in F2:3, F2:4 and F2:5 with 6.05%–10.41% of PV. Another seven stable QTLs could be detected in two populations, including four major effect QTLs: qFL-A12-3, qFS-D10-2, qMC-D6-2, and qMC-D8-1. Fourteen QTL-overlapping regions were found, which might explain the complex correlations among the five phenotypic traits. Four regions on chromosome A11, D3, D6, and D10 covered by both stable and major effect QTLs are promising for further fine mapping. The genomic regions of the two QTLs detected in three populations and the four major effect QTLs contain 810 genes. Gene functional analysis revealed that the annotated genes are mainly involved in protein binding and metabolic pathways. Fifteen candidate genes in the qFL-D3-2 region are highly expressed in fiber or ovules during fiber initiation, elongation, secondary cell wall thickening, or maturation stages. qRT-PCR revealed that Ghir_D03G005440.1 and Ghir_D03G011310.1 may play a role in promoting fiber initiation, Ghir_D03G006470.1 may be beneficial for promoting fiber elongation. This study provides more information for revealing the molecular genetic basis underlying cotton fiber quality.

Preprint ARTICLE | doi:10.20944/preprints202404.1916.v1

Yolo-Chili: An Efficient Lightweight Network Model for Localization of Pepper Picking in Complex Environments

HaiLin Chen, Ruofan Zhang, Jialiang Peng, Hao Peng, Wenwu Hu, Yi Wang, Ping Jiang

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Chili Detection,Automatic Picking,Neural Network,Model Compression

Online: 29 April 2024 (11:14:53 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202404.0793.v1

GreenTray^®, a TIS Bioreactor for Plant Micropropagation and Abiotic or Biotic Stress Bioassays

Ramon Dolcet-Sanjuan, Maria Casanovas, Sandra Franquesa, Eva Alsina, Francisca Carrasco-Cuello, Estanis Torres, Josep Rufat, Cristina Solsona, Neus Teixido

Subject: Biology And Life Sciences, Plant Sciences Keywords: GreenTray®; ; TIS; bioreactor; micropropagation; Biotic and Abiotic Stress Agents Bioassays; Prunus; Pyrus; Malus; Cannabis

Online: 11 April 2024 (11:12:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0498.v1

Treatment of the Fractures of the Humeral Surgical Neck: MIROS versus Intramedullary Nailing. A Retrospective Study

Michelangelo Palco, Gabriele Giuca, Domenico Fenga, Ilaria Sanzarello, Matteo Nanni, Danilo Leonetti

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Proximal Humerus Fractures; MIROS System; Intramedullary Nailing; Orthopedics; Retrospective Study

Online: 6 September 2024 (09:42:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0234.v1

Asymmetric Convolution Guided Multipath Fusion Real-Time Semantic Segmentation Networks

Jie Liu, Bing Zhao, Ming Tian

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Semantic segmentation; Asymmetric convolution; Feature misalignment; High-level semantic information

Online: 3 July 2024 (00:20:55 CEST)

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