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Preprint REVIEW | doi:10.20944/preprints202409.1667.v1

Antioxidant Effects of Aromatic Plant Extracts in Neurodegenerative Diseases: A Review

Youyang Zhu, Miao Tian, Yuliang Qin, Ting Zhao, Zhaofu Li, Dongdong Qin

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Neurodegenerative diseases; Oxidative stress; Antioxidants; Aromatic plants extracts

Online: 20 September 2024 (20:20:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1515.v1

Muscle Fatigue in Health and Disease

Payam Dibaj, Uwe Windhorst

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Muscle Fatigue; Peripheral and Central Fatigue; Neurological Diseases; Group III/IV Muscle Afferents

Online: 20 September 2024 (11:01:17 CEST)

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An untrained couch potato involuntarily forced to undergo a long strenuous exercise towards exhaustion will feel it at the end as a discomforting fatigue. A well-trained athlete will feel the same but after a longer time. Patients of various neurological diseases will do so much earlier. All may also finally experience muscle pain and soreness the next day.Muscle fatigue is an exercise-induced reduction in maximal voluntary muscle force. Muscle fatigability varies with muscle use, age and sex. It is commonly divided into two broad categories: peripheral and central fatigue. The first refers to the many processes in the fatiguing muscle(s), the second to subsequent processes in the central nervous system (CNS). Peripheral muscle fatigue can be caused by numerous different mechanisms, ranging from the accumulation of metabolites within muscle fibers to their damage. Central fatigue involves the inadequacy of the CNS to generate and maintain sufficiently strong motor command. There must of course be a mediator relating the two fatigue types, and this is the collection of small-diameter group III (Aδ) and IV (C) nerve fibers emanating from the muscle and distributing their activation effects throughout the CNS.Muscle fatigue develops during eventually exhausting exercise that goes along with activations of the cardio-vascular and respiratory system to supply oxygen and energy resources. While these functions are supported by a number of sensory afferents, fatigue-activated group III/IV muscle afferents have been proposed to contribute their share to cardio-vascular and ventilatory reflex responses that are mediated in the brainstem. Neural feedback from working skeletal muscle is a vital component in providing a high capacity for endurance exercise because muscle perfusion and O₂ delivery determine the fatigability of skeletal muscle (Amann 2012).The development of chronic muscle fatigue is related to muscle wasting mediated by aging, myopathies, muscle dystrophies, immobilization, insulin resistance, diseases associated with systemic inflammation (arthritis, sepsis, infections), trauma, cardio-vascular (heart failure) and respiratory disorders (chronic obstructive pulmonary disease (COPD)), chronic kidney failure, multiple sclerosis (MS), and, more recently, coronavirus disease 2019 (COVID-19).

Preprint ARTICLE | doi:10.20944/preprints202409.1569.v1

Circulating Blood-Brain Barrier Proteins for Differentiating Ischaemic Stroke Patients from Stroke Mimics

Pragati Kakkar, Meaad Almusined, Tarun Kakkar, Theresa Munyombwe, Linetty Makawa, Kirti Kain, Ahamad Hassan, Sikha Saha

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Ischaemic stroke, Blood-brain barrier, NIHSS, Glial fibrillary acidic protein, Biomarker

Online: 20 September 2024 (10:20:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.2167.v2

Evaluation of Compliance and Accuracy in Parkinson's Disease Motor Symptom Tracking: A Comparative Study of Digital and Traditional Paper Diaries Using a Smartphone Application (My Parkinson’s)

Nazlı Durmaz Çelik, Aslı Yaman Kula, Naci Murat, Müge Kuzu Kumcu, Aydan Topal, Serhat Özkan

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Parkinson’ s Disease; Mobile Applications; Parkinson’ s disease digital diary

Online: 18 September 2024 (13:40:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1392.v1

Cannabis for Tic Control: A Systematic Review and Meta-Analysis of Its Efficacy in Tourette Syndrome Management

Dr. Govind Singh Mann, Dr. Ahmed Farid Gadelmawla, Dr. Ali Dway, Fathima Hayathi Fayaz, Dr. Eleni Asfaw Kebede, Nandha Kumar Varadharaj, Dr. Ayesha Akram, Aneeza Khan, Dr. Uchechi Blessing Azuwike, Dr. Bharath Kanumuri Sampangi, Dr. Oluwaseun Adeolu Ogundijo

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Cannabinoids; Tourette Syndrome; Tics; Endocannabinoid system

Online: 18 September 2024 (12:00:51 CEST)

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Background:Tourette syndrome (TS) is a characterized by motor and vocal tics, often accompanied by obsessive-compulsive disorder (OCD) and attention-deficit/hyperactivity disorder (ADHD). Cannabis-based medicines (CBM) present a promising avenue for future therapeutic intervention owing to their interaction with the endocannabinoid system, potentially mitigating tics and associated symptoms. Unlike conventional treatments such as antipsychotics, CBM exhibits improved tolerability and reduced side effects. While the available evidence is still limited, ongoing research underscores the potential of CBM to enhance the quality of life for patients, establishing it as a pivotal area for future therapeutic advancements in TS. Aim: In our systematic review and meta-analysis, we aim to assess the effectiveness of cannabis-based medicine (CBM) in the treatment of Tourette Syndrome. Methods: We searched in electronic databases (PubMed, Google Scholar, Science Direct, Cochrane Collaboration Database of Randomized Trials) was performed to identify cohort studies and randomized controlled trials (RCTs) up to 18th June 2024. Data extraction focused on baseline characteristics of the included studies and efficacy outcomes, including scores on the Yale Global Tic Severity Scale (YGTSS) and Premonitory Urge for Tics Scale (PUTS). We conducted the meta-analysis using Review Manager version 5.4. software. We compared the measurements before and after CBM intake using mean difference (MD) and 95% confidence interval (CI). Result: In total, 1105 articles were identified for screening, with eight studies included in the systematic review and seven in the meta-analysis. These studies involved 306 adult patients with TS treated with cannabis. YGTSS revealed a significant reduction in total scores (MD = -13.29, 95% CI [-21.67 to -4.91], P = 0.002) and PUTS revealed a significant decrease in scores (MD = -4.09, 95% CI [-7.24 to -0.93], P = 0.01). Conclusion: The research emphasizes the potential of cannabis-based medication in alleviating tics and premonitory urges associated with Tourette syndrome. While the initial results are promising, they are based on limited-scale studies. It is imperative to conduct larger, placebo-controlled trials encompassing diverse demographic groups to substantiate the effectiveness, ensure safety, and optimize dosages for long-term therapeutic advantages.

Preprint ARTICLE | doi:10.20944/preprints202409.1409.v1

Beyond Genetics: The Role of Familial Comorbidities in Shaping Migraine Phenotypes

Tugce Ozdemir Gultekin, Sevim Eyupoglu, Ezgi Uluduz, Derya Uluduz, Aynur Ozge

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: migraine; chronic migraine; episodic migraine; familial transmission; comorbidities; hypercholesterolemia; headache clinics

Online: 18 September 2024 (11:44:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1269.v1

Hallmarks of Brain Plasticity

Yauhen Statsenko, Nik V. Kuznetsov, Milos Ljubisavljevic

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: brain plasticity; molecular biomarkers; RNA diagnostics; RNA therapeutics; transcriptomics; ncRNA; lncRNA; miRNA; circRNA; eRNA; lincRNA; piRNA; yRNA

Online: 17 September 2024 (08:00:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1235.v1

Aetiology, Clinical Profiles, Laboratory Parameters, Radiological Findings and Clinical Outcomes in Patients Admitted with Acute Encephalitis Syndrome in a Tertiary Care Center During 2023 in Myanmar

Aung Kyaw Kyaw, Ohnmar Ohnmar, Zin Nwe Win, Sai Kyaw Win, Zarni Myint Shwe, Kyaw Lwin Show, Nan Aye Thida Oo, Mya Thandar Win, Khin Zarchi Aung, Win Pa Pa Naing, Phyu Phyu Lay, Hlaing Myat Thu, Zaw Than Htun

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Acute encephalitis syndrome; infectious cause; autoimmune encephalitis; adult; Myanmar; 2023

Online: 17 September 2024 (06:17:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1165.v1

Evaluating the Effects of Frequency of STN-DBS on Postural Control in Parkinson's Disease: A Case-Series Study

Nazlı Durmaz Çelik, Aslı Yaman Kula, Elif Göksu Yiğit Tekkanat, Müge Kuzu Kumcu, Mehmet Yanardağ, Serhat Özkan

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Postural control; Deep Brain Stimulation; Subthalamic Nucleus; Parkinson's Disease; Sensory Organization Test

Online: 16 September 2024 (12:16:30 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202409.1086.v1

Anti-calcitonin Gene-Related Peptide Monoclonal Antibody Is Effective for Preventing Migraine Aura without Headache

Yasushi Shibata

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: aura, migraine, cortical spreading depression, calcitonin gene-related peptide

Online: 13 September 2024 (11:51:39 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.0777.v2

Review of Multimodal Data Acquisition Approaches for Brain-Computer Interfaces

Sayantan Ghosh, Domokos Máthé, Harishita Purushothaman Bhuvana, Pramod Sankarapillai, Anand Mohan, Raghavan Bhuvanakantham, Balázs Gulyás, Parasuraman Padmanabhan

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Brain Computer Interface; data acquisition modalities; functional near-infrared spectroscopy; electroencephalography; functional magnetic resonance imaging; multimodal integration; signal processing

Online: 13 September 2024 (04:21:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0967.v1

Visual Evoked Potentials Sensitization/Habituation Mechanisms in Chronic Migraine Patients with or without Medication Overuse

Gianluca Coppola, Francesco Casillo, Gabriele Sebastianelli, Chiara Abagnale, Cherubino Di Lorenzo, Antonio Di Renzo, Mariano Serrao, Vincenzo Parisi

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Medication overuse; chronic migraine; visual cortex; amplitude; medication withdrawal

Online: 12 September 2024 (17:49:53 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202409.0766.v1

Synergistic Effects of Incobotulinum Toxin and Physiotherapy in a Rare Case of Paraparesis in a 7-Years-Old Affected by Klippel-Feil Syndrome Related to MYH3 Gene Mutation: A Case Report

Maurizio Ranieri, Mariagrazia Riccardi, Maria Vittoria Raele, Giacomo Farì, Marisa Megna, Riccardo Marvulli

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Klippel-Feil Syndrome; Myosin Heavy Chain 3 mutation; MYH3 mutation; spine defects; spasticity; botulinum toxin type A; incobotulinum; therapeutic exercise; physiotherapy

Online: 10 September 2024 (15:20:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.0724.v1

Autoimmune Encephalitis and Paraneoplastic Neurological Syndromes with Progressive Supranuclear Palsy-Like Manifestations

Naoki Yamahara, Akira Takekoshi, Akio Kimura, Takayoshi Shimohata

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: progressive supranuclear palsy; autoimmune encephalitis; paraneoplastic neurological syndrome

Online: 10 September 2024 (12:46:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0714.v1

Association of Loneliness with Functional and Cognitive Status in Minor and Major Neurocognitive Disorders

Maria Claudia Moretti, Iris Bonfitto, Luciano Nieddu, Ivana Leccisotti, Savino Dimalta, Giovanni Moniello, Madia Lozupone, Antonello Bellomo, Francesco Panza, Carlo Avolio, Mario Altamura

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: loneliness; mild cognitive impairment; dementia; Alzheimer’ s disease; MMSE; ADL; IADL; depression; multimorbidity

Online: 10 September 2024 (08:10:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0573.v1

Utilization of Vestibular Information for Balance Control in Children with Chiari I Malformation

Irène Stella, Philippe Perrin, Matthieu Casteran, Anthony Joud, Art Mallinson, Olivier Klein

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Chiari I malformation; paediatric neurosurgery; posturography; balance

Online: 9 September 2024 (07:55:20 CEST)

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Background: Surgery for Chiari I malformation (CMI) is indicated when typical clinic-radiological features (syringomyelia, exertional headaches, sleep apnea syndrome, tetraparesis) are present. Sometimes patients have atypical complaints suggestive of otolaryngological (ENT) involvement, and it is sometimes difficult for the neurosurgeon to determine if these complaints are related to the CMI. Our aim was to describe postural control pattern in children with CMI using Computerized Dynamic Posturography. To our knowledge, this is the first study addressing postural instability in paediatric CMI patients. Methods: twenty-eight children aged 6 to 17 years with both radiologically confirmed CMI and clinical ENT complaints were included. Children were separated into 2 groups: operated and non-operated patients, basing on neurosurgical indication. Epidemiologic and posturographic results (CDP - Equitest®) were compared between both groups, as well as pre and post operatively in the group 2. Results: in Group 2 patients, significant improvement of global SOT was found after intervention. When the three sensorial aspects of postural control calculated by the system were independently assessed, the greatest improvement was in the vestibular ratio. We also observed an altered CoG pattern (“lateral deviation”) in the Group 2 patients, which significantly differed from Group 1. Lateral deviation was significantly reduced postoperatively in Group 2 patients. A correspondence between preoperative MRI and side of lateralisation on posturography was found in 4 children, but this cannot be regarded as significant due to the low number of patients. Conclusions: postural control seems to improve after surgery for CMI in children, mostly due to improvement in vestibular function. There is a correspondence between the side of lateral deviation and the side of greatest tonsillar descent on MRI and perioperatively. Further studies are needed to support these results and to confirm utility of CDP in CMI patients.

Preprint REVIEW | doi:10.20944/preprints202407.1943.v2

Obesity Control and Supplementary Nutraceuticals as Co-Factors of Brain Plasticity in Multiple Sclerosis Populations

Lorena Ciumarnean, Oliviu Florențiu Sârb, Nicu Catalin Draghici, Octavia Salagean, Mircea Vasile Milaciu, Olga Hilda Orasan, Calin Vasile Vlad, Irina Maria Vlad, Teodora Alexescu, Ioana Para, Simina Tarmure, Elisabeta Ioana Hiriscau, Gabriela Bombonica Dogaru

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: multiple sclerosis; neurodegeneration; neurorehabilitation; nutraceuticals; obesity

Online: 9 September 2024 (04:39:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0523.v1

Respiratory Trajectories and Correlation with Serum Biochemical Indices in Spinal and Bulbar Muscular Atrophy

Federica Ginanneschi, Caterina Bigliazzi, Flora Anna Cimmino, Stefania Casali, Pietro Pelliccioni, Emanuele Emmanuello, Elena Bargagli, Nicola De Stefano

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: blood analysis; Kennedy’ s disease; spirometry

Online: 6 September 2024 (13:18:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.0527.v1

Moyamoya Disease: Current Knowledge and Future Directions

Mohamed Jayte, Awil Abdi

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Moyamoya disease; literature review; pathogenesis; diagnosis; treatment; prognosis

Online: 6 September 2024 (13:12:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0435.v1

Patients with Allan-Herndon-Dudley Syndrome (MCT8 Deficiency) Display Symptoms of Parkinsonism in Childhood and Respond to Levodopa/Carbidopa Treatment

Nina-Maria Wilpert, Angela L. Hewitt, Roser Pons, Marie-Thérèse Henke, Andrea Dell’Orco, Martin Bauer, Christiane Grolik, Stephan Menz, Monika Wahle, Annika Zink, Alessandro Prigione, Christina Reinauer, Catharina Lange, Christian Furth, Knut Brockmann, Sabine Jung-Klawitter, Stine Christ, Angela M. Kaindl, Anna Tietze, Heiko Krude, Thomas Opladen, Markus Schuelke

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: MCT8; SLC16A2; movement disorder; parkinsonism; dopamine; iPSC cell model

Online: 6 September 2024 (03:56:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0391.v1

Biopsychosocial impediments in MS: Gender Differences and Impact of Quality of Life on Neuropsychological Function: Multicenter study

Maisaa Ghanim Al Dhahri, Mai Helmy, Neeraja Rajeev, Aseel Al Toubi, Hiba Al-Abdali, Abdullah Al-Asmi, Iman Redha Al-Lawati, Issa Al-Adawi, Lakshmanan Jeyaseelan, Samir Al-Adawi

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Multiple sclerosis, neuropsychological performance, gender differences, quality of life, and cognitive functioning

Online: 5 September 2024 (09:28:07 CEST)

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Background/Objectives: Multiple sclerosis (MS) is a chronic neurological disorder characterized by various clinical presentations and manifestations that include biopsychosocial impediments. This study has three interrelated goals relevant to biopsychosocial functioning. The first is to compare cognitive, neuropsychological, and affective functioning and quality of life between patients with MS (PwMS) and a control group. The second is to examine whether cognitive and neuropsychological performance is affected by gender, and the third is to examine whether variation in QoL hinges on cognitive neuropsychological performance. Methods: This multicenter study was carried out among clinically stable PwMS under follow-up in two tertiary care units in urban Oman. Healthy controls, matched for age and sex, were also recruited as a comparison group. Data were collected using cognitive batteries sensitive to current reasoning ability and conventional neuropsychological batteries designed to measure verbal learning, visual-spatial ability, and processing speed. The affective range (anxiety and depressive symptoms) and quality of life (QoL) were also assessed. Results: The PwMS group scored lower on current reasoning ability, verbal learning, visual-spatial ability, and processing speed compared with the control group. The incidence of anxiety was higher in the PwMS group but there was no statistically significant difference in depressive symptoms. No significant differences were found in cognitive variables between the two sexes, except in visual-spatial ability, where women outperformed men. PwMS with low QoL scored lower on the attention and concentration indices than those with adequate QoL. According to QoL, no significant differences were observed in reasoning, verbal learning, and visual-spatial ability. Conclusions: The present sentinel study suggests that the Omani cohort with MS tends to have lower indices of current reasoning ability, visual and spatial memory and cognitive speed compared to control subjects. Gender differences are minimal, except for visual-spatial abilities where women outperform men. Quality of life significantly affects cognitive functioning. In general, the biopsychosocial impediment appears to be significant, indicating the need for comprehensive evaluation and care in the management of MS.

Preprint REVIEW | doi:10.20944/preprints202409.0258.v1

“Beyond the Knife” - Applying Theranostic Technologies to Enhance Outcomes in Neurosurgical Oncology

Santosh Guru, Fred C Lam, Yusuke S Hori, Deyaaldeen AbuReesh, Armine Tayag, Sara C Emrich, Louisa Ustrzynski, David J Park, Steven D Chang

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: brain tumors; gliomas; radiosurgery; Cyberknife; nanotechnology; blood-brain barrier; chemotherapy; neurosurgery; neuro-oncology; image-guided surgery; fluorescence-guided surgery

Online: 3 September 2024 (20:00:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.2265.v1

Quantitative Measurement of Blood Flow in the Internal Jugular Veins in Different Body Positions in Healthy Subjects

Agata Kawalec, Joanna Czaja, Marcin Skuła, Marian Simka

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: internal jugular vein; blood flow; body position

Online: 3 September 2024 (05:06:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.0110.v1

Cgrp Monoclonal Antibodies: Key Lessons from Real World Evidence

Bianca Orlando, Gabriella Egeo, Cinzia Aurilia, Giulia Fiorentini, Piero Barbanti

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: migraine; anti-CGRP mAbs; treatment; real-life; disability

Online: 2 September 2024 (13:38:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.2245.v1

Comparative Performance of Autoencoders and Traditional Machine Learning Algorithms in Clinical Data Analysis for Predicting Post-Staged GKRS Tumor Dynamics

Simona Ruxandra Volovăț, Tudor Ovidiu Popa, Dragoș Rusu, Lăcrămioara Ochiuz, Decebal Vasincu, Maricel Agop, Călin Gheorghe Buzea, Cristian Constantin Volovăț

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: gamma knife radiosurgery (GKRS); brain metastasis; tumor dynamics forecasting; machine learning models; autoencoders

Online: 2 September 2024 (11:20:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0054.v1

Lateral Antebrachial Cutaneous Nerve Neuropathy: Electrodiagnostic Findings and Etiologies in 49 Cases

Vasudeva Iyer, Lisa B.E. Shields, Yi Ping Zhang, Christopher B. Shields

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Neurology; lateral antebrachial cutaneous nerve; musculocutaneous nerve; biceps tendon repair; iatrogenic nerve injury; sensory nerve conduction study

Online: 2 September 2024 (08:45:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.2167.v1

Evaluation of Compliance and Accuracy in Parkinson's Disease Motor Symptom Tracking: A Comparative Study of Digital and Traditional Paper Diaries Using a Smartphone Application (My Parkinson’s)

Nazlı Durmaz Çelik, Aslı Yaman Kula, Naci Murat, Aydan Topal, Serhat Özkan

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Parkinson’s Disease; Mobile Applications; Parkinson’s disease digital diary

Online: 29 August 2024 (15:15:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.2030.v1

Cerebrospinal Fluid Total, Phosphorylated and Oligomeric A-synuclein in Parkinson’s Disease. A Systematic Review, Meta-Analysis and Meta-Regression Study

Ioanna Kapsali, Maria-Evgenia Brinia, Vasilios C. Constantinides

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: synuclein; Parkinson’s disease; cerebrospinal fluid; biomarkers; review; meta-analysis

Online: 28 August 2024 (13:41:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1776.v1

Impact of Epstein-Barr Virus Nuclear Antigen 1 on Neuroinflammation in PARK2 Knockout Mice with Mitochondrial Dysfunction

Davide Cossu, Yuji Tomizawa, Sachiko Noda, Eiichi Momotani, Tamami Sakanishi, Hanna Okada, Kazumasa Yokoyama, Leonardo A. Sechi, Nobutaka Hattori

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Epstein-Barr Virus; PARK2 Knockout Mice: ; Mitochondrial Dysfunction ;

Online: 26 August 2024 (06:58:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1703.v1

A Single Dose Intraperitoneal Injection of P. gingivalis Outer Membrane Vesicle (OMV) Stimulated Expressions of Neuroinflammatory Markers and Histopathological Changes in the Brain of Adult Zebrafish

Malik Adewoyin, Hamarsha Mohamed, Rasaq Akinsola, Seong Lin Teoh, Mohammad Noor Amall Azmai, Noraini Abu Bakar, Nurrul Shaqinah Nasruddin

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: P. gingivalis; Outer membrane vesicles; Neuroinflammation

Online: 25 August 2024 (06:38:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1470.v1

Neuroprotective Properties of Rutin Hydrate against Scopolamine-Induced Learning and Memory Deficits in Rats

Inturu Sreelatha, Ga-Young Choi, In-Seo Lee, Omkaram Inturu, Hyun-Sook Lee, Yea-Na Park, Cheol-Won Lee, Sungho Maeng, Ji-Ho Park

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Rutin hydrate; scopolamine; long-term potentiation; Alzheimer’s disease; synaptic plasticity

Online: 20 August 2024 (12:50:04 CEST)

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The current study investigated the neuroprotective effects of rutin hydrate (RH) in an Alzheimer’s disease (AD)-like learning and memory impairments rat model. Since AD is an age-related degenerative brain disorder characterized by a progressive worsening in cognitive function and memory, RH may be a potential drug for the treatment of AD-like memory loss, and this work is aimed to evaluate whether RH has neuroprotective effects in memory deficits induced by scopolamine (SCO). In our study, RH demonstrated beneficial effects as a neuroprotector in the brain and improved learning, memory, and synaptic plasticity in a rat. Rats were administered RH (100 mg/kg) and SCO (1.5mg/kg), and performed behavioral tests such as Morris water navigation test, Y-maze test, and passive avoidance test to evaluate the ability of learning and memory. In accordance with these findings, RH behaviorally attenuated SCO-induced shortening of step-through latency in the PA test, increased the percent of alternation in the Y-maze, and increased the time spent in the target zone in the MWN. Moreover, the neuroprotective effect of RH on learning and memory was investigated through the long-term potential on organotypic hippocampal slice cultures. RH increased the total activity of field excitatory postsynaptic potential (fEPSP) following theta burst stimulation and attenuated SCO-induced blockade of fEPSP. This approach could potentially be used as a therapeutic strategy for the restoration of learning and memory function and the prevention of the progression of AD. SCO treatment decreased the levels of BDNF/TrkB/ERK/CREB/Bcl2 and increased the Bax protein level in rat hippocampus. RH ameliorated the expression of these proteins by attenuating SCO-induced up or downregulation in the hippocampus. Based on these findings, the results highlight the molecular and cellular mechanisms through which RH is proposed to exert its neuroprotective effects in the prevention and treatment of learning and memory deficit disorders.

Preprint ARTICLE | doi:10.20944/preprints202408.1437.v1

Trans-Sphenoidal Endoscopic Approach in Pituitary Adenomas: Clinical and Laboratory Outcome Analysis of a Single Center

Denis Aiudi, Alessio Iacoangeli, Andrea Mattioli, Valentina Liverotti, Lucia di Somma, Maurizio Gladi, Maurizio Iacoangeli, Mauro Dobran

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Pitnet, pituitary adenoma, endoscopic, hormones, transsphenoidal

Online: 20 August 2024 (12:39:50 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.1269.v1

Histaminergic System Activity in the Central Nervous System (CNS) – the Role in Neurodevelopmental and Neurodegenerative Disorders

Dariusz Szukiewicz

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: histamine; histamine receptors; neurodevelopmental disorders; neurodegenerative diseases; histaminergic neurons; tuberomammillary nucleus; neuroinflammation; histamine H3 receptor; histamine H3 receptor antagonist/inverse agonist; autism spectrum disorders; Alzheimer’s disease

Online: 20 August 2024 (05:01:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.1375.v1

Oxidative Stress and Mitochondrial Dysfunction in Alzheimer's Disease: Insights into Pathophysiology and Treatment

AMER ALKHALIFA, Oula Alkhalifa, Iva Durdanovic, Dalia R. Ibrahim

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer's disease; Oxidative stress; Mitochondrial dysfunction; Antioxidant; Reactive oxygen species.

Online: 19 August 2024 (16:45:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1325.v1

Sensory Processing Challenges in Children with Neurodevelopmental Disorders and Genetic Conditions: An Observational Study

Ekaine Rodríguez-Armendariz, María Vela-Romero, Adrián Galiana

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: sensory processing; neurodevelopmental disorders; Autism Spectrum Disorder; Attention Deficit Hyperactivity Disorder; Learning Disorder; Developmental Disorder; Williams Syndrome; 22q11.2 Deletion Syndrome; Pseudohypoparathyroidism; children

Online: 19 August 2024 (12:13:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1197.v1

Wearable Sensor-Based Assessments for Remotely Screening Early-Stage Parkinson’s Disease

Shane Johnson, Michalis Kantartjis, Joan Severson, E. Ray Dorsey, Jamie L Adams, Tairmae Kangarloo, Melissa A Kostrzebski, Allen Best, Michael Merickel, Dan Amato, Brian Severson, Sean Jezewski, Steve Polyak, Anna Keil, Josh Cosman, David Anderson

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Parkinson’s disease; wearable sensors; digital biomarkers; remote monitoring; gait analysis; phonation; feature engineering; mobile health technologies; early detection

Online: 16 August 2024 (10:02:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1204.v1

Clinicopathological Observations in Acute Stroke Patients Treated with Intravenous Thrombolysis

Lilla Hudák, Kitti Bernadett Kovács, Zsuzsa Bagoly, Istvan Szegedi, Viktor Bencs, Linda Lóczi, Rita Orbán-Kálmándi, Henrietta Péter-Pakó, Zsófia Fülesdi, Blanka Busi, Attila Nagy, Beáta Perjési-Kiss, László Oláh, László Csiba

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: ischemic stroke; autopsy; hemorrhagic transformation

Online: 16 August 2024 (05:53:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1125.v1

VEGF, but Not BDNF, Prevents the Downregulation of KCC2 Induced by Axotomy in Extraocular Motoneurons

Jaime Capilla-López, Rosendo G Hernández, Génova Carrero-Rojas, Paula M Calvo, Francisco J Alvarez, Rosa R de la Cruz, Angel M Pastor

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: oculomotor system; cation-chloride cotransporters; nerve injury; choline acetyltransferase (ChAT); vascular endothelial growth factor; brain-derived neurotrophic factor; GABA depolarization; neurological diseases; chloride homeostasis; NKCC1

Online: 15 August 2024 (15:09:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.1124.v1

A Scoping Review on Technology-Based Approaches for Upper Limb Motor Rehabilitation after Stroke. Are We Really Targeting Severe Impairment?

Emma Colamarino, Giovanni Morone, Jlenia Toppi, Angela Riccio, Febo Cincotti, Donatella Mattia, Floriana Pichiorri

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: technological interventions; motor rehabilitation; upper limb; stroke; severe impairment; Exoskeleton; Neuroplasticity; Rehabilitation; Robotic training; Brain Computer Interfaces; Virtual Reality

Online: 15 August 2024 (06:28:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.0889.v1

Intercellular Adhesion Molecule 1 (ICAM-1): An Inflammatory Regulator with Potential Implications in Ferroptosis and Parkinson’s Disease

Matthew R Miller, Harold E Landis, Robert E Miller, Yousef Tizabi

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: ICAM-1; Parkinson’s disease; Ferroptosis; Glial cells; T cells; Neuroinflammation

Online: 14 August 2024 (02:30:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0941.v1

Electrolyte Imbalance in Acute Traumatic Brain Injury: Insights from the First 24 Hours

Alina Săcărescu, Mihaela-Dana Turliuc

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: traumatic brain injury; electrolytes; early monitoring; Glasgow Coma Scale; chloride; potassium

Online: 13 August 2024 (14:39:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.0728.v1

The Indissociable Triad: Vascular Impairment, Muscle Atrophy, and Cognitive Decline

Enzo Pereira de Lima, Masaru Tanaka, Caroline Barbalho Lamas, Karina Quesada, Claudia Rucco P. Detregiachi, Adriano Cressoni Araújo, Elen Landgraf Guiguer, Virgínia Maria Cavallari Strozze Catharin, Marcela Vialogo Marques de Castro, Edgar Baldi Junior, Bruna Fidencio Rahal Ferraz, Vitor Cavallari Strozze Catharin, Lucas Fornari Laurindo, Sandra Maria Barbalho

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: vascular diseases; vascular atrophy; cognitive dysfunction; neurodegenerative diseases; oxidative stress; inflammation; aging; insulin resistance; nutrients; comorbidity

Online: 12 August 2024 (15:58:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0813.v1

Subthreshold Cannabidiol Potentiates Levetiracetam in the Kainic Acid Model of Temporal Lobe Epilepsy

Chiara Lucchi, Mattia Marcucci, Kawther Ameen Muhammed Saeed Aledresi, Anna-Maria Costa, Giuseppe Cannazza, and Giuseppe Biagini

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: cannabidiol; epilepsy; kainic acid; levetiracetam

Online: 12 August 2024 (14:14:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.0819.v1

Comparing the Impact of Low Frequency vs High Frequency Deep Brain Stimulation in Patients with Parkinson’s Disease: A Systematic Review

Govind Singh Mann, Sanam Wasim Khan, Thrinatha Movva, Abdalla Malik, Leeda Ahmadi, MD Parbej Allam, Binay Panjiyar

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Parkinson’ s disease; deep brain stimulation; neurology; neuro-degenerative diseases

Online: 12 August 2024 (13:43:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0649.v1

Determination of Recovery by Healing or Compensation Using Multifrequency Vestibular Tests and Subjective Functional Scales in a Human Model of Vestibular Neuritis

Enrico Armato, Georges Dumas, Flavio Perottino, Matthieu Casteran, Philippe Perrin

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Vestibular Neuritis; Recovery by healing; Recovery by compensation; Dizziness Handicap Inventory; Bithermal Caloric Test - Video Head Impulse Test; Skull Vibration-Induced Nystagmus Test

Online: 12 August 2024 (03:02:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0694.v1

Normalization of Fetal Cerebral and Hepatic Iron by Parental Iron Therapy to Pregnant Rats with Systemic Iron Deficiency without Anemia

Annette Burkhart, Kasper Bendix Johnsen, Tina Skjørringe, Asbjørn Haaning Nielsen, Lisa Juul Routhe, Sandra Sandra Hertz, Lisbeth Birk Møller, Lars Lykke Thomsen, Torben Moos

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: copper; ferroportin; hepcidin; iron; iron-deficiency; zinc

Online: 9 August 2024 (10:25:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0405.v1

Effectiveness and Tolerability of Anti-Calcitonin Gene-related Peptide Therapy for Migraines and Other Chronic Headaches in Adolescents and Young Adults: A Retrospective Study in the USA

Anjaneya Shankar Madhav Bandatmakur, Pooja Dave, Melissa Kerr, Colin Brunick, Sijin Wen, Nicholas Hansen

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: pediatric headache; migraine; anti- CGRP; headache; anti migraine

Online: 6 August 2024 (10:41:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0412.v1

Early Diagnosis of CNS Virus Infections from Neurological Autoimmune Diseases: A Cross-Sectional Study Results from China in Er Setting

Daiquan Gao, Xue Lv, Zuoyao Shen, Huicong Wang, Wenfeng Zhao, Huang Wang, Xiukun Jin, Liuchen Tan, Lu Yin, Junhui WANG, Weihua Yue, Hongxing Wang

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: central nervous system; virus infections; neurological autoimmune diseases; differentiation

Online: 6 August 2024 (10:12:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.0229.v1

Mesenchymal Stem Cell-Derived Exosomes as a Neuroregeneration Treatment for Alzheimer's Disease

Siddharth Shah, Hadeel M. Mansour, Tania M. Aguilar, and Brandon Lucke-Wold

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer's disease; mesenchymal stem cells; Drug discovery and development; Neurosurgery; Neurology; Novel theapies

Online: 6 August 2024 (05:20:17 CEST)

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Background: Neuroprotective and immunomodulatory microRNAs derived from mesenchymal stem cells (MSCs), neural growth factors, and anti-inflammatory cytokines are contained in nano-sized extracellular vesicles called mesenchymal stem cell-derived exosomes (MSC-Exo). These vesicles attenuate neuro-inflammation, promote neo-vascularization, induce neurogenesis, and decrease the apoptotic loss of neural cells. Methods: Systematic retrieval of information was performed on PubMed. 60 articles were found in a search on Mesenchymal Stem Cell, Exosomes, and Alzheimer's Disease. These 2 articles were Meta-analyses, Randomized Controlled Trials, clinical trials, and Systematic Reviews. The rest were Literature review articles. These articles were till the year 2024. Appropriate studies were isolated, and important information from each of them was understood and entered into a database from which the information was used in this article. The clinical trials on Mesenchymal Stem Cell Exosomes for Alzheimer's Disease were searched on clinicaltrials.gov. Results: Several experimental investigations have shown that MSC-Exo improves cognitive im-pairment in rats. In this review paper, we summarized existing understanding regarding the molecular and cellular pathways behind MSC-Exo-based cognitive function restoration, with a focus on MSC-Exos therapeutic potential in the treatment of Alzheimer's disease. Conclusion: AD is a significant health issue in our culture and is linked to several important neuropathological characteristics. Exosomes generated from stem cells, such as MSCs or NSCs, have been examined more and more in a variety of AD models, indicating that they may be viable therapeutic agents for the treatment of diverse disorders. Exosome yields may be increased and their therapeutic efficacy can be improved using a range of tailored techniques and culture conditions. It is necessary to provide standardized guidelines for exosome manufacture to carry out excellent preclinical and clinical research.

Preprint ARTICLE | doi:10.20944/preprints202408.0177.v1

Phenotypic Variability of LGMD 2C/R5 in a Genetically Homogenous Group of Bulgarian Muslim Roma

Ani Taneva, David Gresham, Velina Guergueltcheva, Teodora Chamova, Veneta Bojinova, Mariana Gospodinova, Maria Katzarova, Radoslav Petkov, Thomas Voit, Lidia Aneva, Ognyan Asenov, Bilyana Georgieva, Violeta Mihaylova, Stoyan Bichev, Tihomir Todorov, Albena Todorova, Luba Kalaydjieva, Ivailo Tournev

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: LGMD 2C/R5; gamma-sarcoglycanopathy; Bulgarian Muslim Roma

Online: 2 August 2024 (11:20:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0036.v1

Evaluation of MAOA Gene Polymorphism on the Efficacy of Antidepressant Treatment and Craving Severity for Betel-Quid Use Disorder

Hung Chung-Chieh, Ko Ying-Chin, Chen Ping-Ho, Chung Chia-Min

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: betel-quid use disorder; Craving Severity; MAOA Gene Polymorphism; Personalized Medicine; Randomized Clinical Trial

Online: 2 August 2024 (05:54:13 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202408.0091.v1

Epilepsy and Myasthenia Gravis, a Case Series

Iñigo Oyarzun, Guillermo Hernández, Jacint Sala-Padró, Francisco Morandeira, Carlos Casasnovas, Mercè Falip

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: myasthenia gravis; epilepsy; autoimmunity; comorbidity; focal epilepsy; selenium

Online: 2 August 2024 (02:52:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2523.v1

Inhibition of IRAP Enhance the Expression of Pro-cognitive Markers Drebrin and MAP2 in Rat Primary Neuronal Cells

Frida Stam, Sara Bjurling, Erik Nylander, Esther Olaniran Håkansson, Nicholas Barlow, Johan Gising, Mats Larhed, Luke R. Odell, Alfhild Grönbladh, Mathias Hallberg

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: cognition; cortex; dendritic spines; hippocampus; insulin regulated aminopeptidase (IRAP); microtubule associated protein 2 (MAP2); primary cell cultures

Online: 31 July 2024 (10:24:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.2503.v1

Trehalose: Neuroprotective Effects and Mechanisms—An Updated Review

Borislav Sevriev, Simeonka Dimitrova, Gabriela Kehayova, Stela Dragomanova

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: trehalose; neuroprotection; apoptosis; neuroinflammation; oxidative stress

Online: 31 July 2024 (08:33:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2475.v1

EEG for Neurological Prognostication in Post-anoxic Coma Following Cardiac Arrest and Its Relationship to Outcome

Zaitoon Shivji, Nathaniel Bendahan, Carter McInnis, Timothy Woodford, Michael Einspenner, Lisa Calder, Lysa Boissé Lomax, Garima Shukla, Gavin Paul Winston

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Cardiac arrest; electroencephalography; anoxic coma; prognosis

Online: 30 July 2024 (16:57:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2239.v1

Efficacy of a Virtual Reality Rehabilitation Protocol based on Art Therapy in Subacute Phase of Stroke

Gaetano Tieri, Marco Iosa, Antonio Fortini, Federica Aghilarre, Federico Gentili, Cristiano Rubeca, Tommaso Mastropietro, Gabriella Antonucci, Roberto De Giorgi

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: neurorehabilitation; art therapy; neuroaesthetics; cerebrovascular accident; recovery

Online: 30 July 2024 (11:41:23 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202407.2466.v1

PSEN2 Mutations May Mimic Frontotemporal Dementia: Two New Case Reports and a Systematic Review

Anxo Manuel Minguillon Pereiro, Beatriz Quintans Castro, Alberto Ouro, Jose Manuel Aldrey Vazquez, Julia Cortes Hernandez, Marta Aramburu Nuñez, Manuel Arias Gomez, Isabel Martin Jimenez, Tomás Sobrino, Juan Manuel Pias Peleteiro

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer’ s disease; frontotemporal dementia; presenilin 2; phenocopies; white matter hyperintensities

Online: 30 July 2024 (11:39:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2337.v1

Resting-State EEG Alterations of Practice-Related Spectral Activity and Connectivity Patterns in Depression

Elisa Tatti*, Alessandra Cinti, Anna Serbina, Adalgisa Luciani, Giordano D’Urso, Alberto Cacciola, Angelo Quartarone, Maria Felice Ghilardi

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Depression; EEG Oscillations; Fractal Dynamics; Phase-Amplitude Coupling; Resting State EEG; Beta frequency; Gamma frequency; Plasticity; Energy

Online: 30 July 2024 (07:35:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2364.v1

A Novel Noninvasive Murine Model of Neonatal Hypoxic Ischemic Encephalopathy Demonstrates Developmental Delay and Motor Deficits with Activation of Inflammatory Pathways in Monocytes

Elise A. Lemanski, Bailey A. Collins, Andrew T. Ebenezer, Sudha Anilkumar, Victoria Langdon, Qi Zheng, Shanshan Ding, Karl Franke, Jaclyn M. Schwarz, Elizabeth Wright-Jin

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: hypoxic ischemic encephalopathy; maternal immune activation; motor; development; microglia; macrophages

Online: 30 July 2024 (04:38:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2041.v1

Can Selected Parameters of Brain Injury Reflect Neuronal Damage in Smoldering Multiple Sclerosis?

Natalia Niedziela, Maria Nowak-Kiczmer, Lina Malciene, Mariusz Stasiołek, Jolanta Zalejska-Fiolka, Zenon P Czuba, Jacek T Niedziela, Jarosław Szczygieł, Michał Lubczyński, Monika Adamczyk-Sowa

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: NF-H; GPAF; S100B; UCHL1; interleukins; smoldering multiple sclerosis; neurodegeneration; neuroinflammation

Online: 25 July 2024 (12:01:33 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1997.v1

The Effect of Music Therapy on Substance Use Disorder Patients in the Rehabilitation Stage

Jasmin Jabara, Vivian Ooi

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: music therapy; substance use disorder (SUD); craving; addiction; emotional expression; depression

Online: 25 July 2024 (09:19:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1962.v1

Influence of Stigma on the Diagnosis and Treatment of Migraine

Casas-Limón J, Quintas S, López-Bravo A, Alpuente A, Andrés-López A, Castro-Sánchez MV, Membrilla JA, Morales-Hernández Cristian, González-García N, Irimia Pablo

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: migraine; stigma; disability; stereotypes; workplace

Online: 24 July 2024 (12:39:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1943.v1

Obesity Control and Nutraceuticals in the Aid of Brain Plasticity in Multiple Sclerosis Patients

Lorena Ciumarnean, Oliviu Florențiu Sârb, Nicu Catalin Draghici, Octavia Salagean, Mircea Vasile Milaciu, Olga Hilda Orasan, Calin Vasile Vlad, Irina Maria Vlad, Teodora Alexescu, Ioana Para, Simina Tarmure, Ioana-Elisabeta Hiriscau, Gabriela Bombonica Dogaru

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: multiple sclerosis; nutraceuticals; neurodegeneration; neuroregeneration; brain plasticity; vitamin D3; flavonoids; terpenes

Online: 24 July 2024 (11:40:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1915.v1

Neurosteroid Levels in GBA and Non-mutated PD: A Possible Factor Influencing Clinical Phenotype?

Francesco Cavallieri, Chiara Lucchi, Sara Grisanti, Edoardo Monfrini, Valentina Fioravanti, Giulia Toschi, Giulia Di Rauso, Jessica Rossi, Alessio Di Fonzo, Giuseppe Biagini, Franco Valzania

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: GBA; glucocerebrosidase; neurosteroids; Parkinson’ s disease; psychiatric disorders

Online: 24 July 2024 (09:30:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1766.v1

Tractography Insights into Anticipatory Postural Adjustment and Freezing of Gait in Parkinson's Disease

Andrea C. de Lima-Pardini, Mariana Penteado Nucci, Claudia Neves de Oliveira, Eduardo Joaquim Lopes Alho, Daniel Boari Coelho

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: movement disorders; step initiation; white matter integrity; diffusion tensor imaging

Online: 23 July 2024 (09:44:38 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1728.v1

Biomarkers and Rehabilitation for Functional Neurological Disorder

Victor W Mark

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: functional neurological disorder; MRI; rehabilitation

Online: 23 July 2024 (07:14:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1712.v1

Oligonucleotide Therapies for Facioscapulohumeral Muscular Dystrophy: Current Preclinical Landscape

Samuel L Beck, Toshifumi Yokota

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: facioscapulohumeral muscular dystrophy (FSHD); DUX4; antisense oligonucleotides; RNAi; CRISPR; DNA aptamers; DNA decoys; targeted therapy; genetic therapy

Online: 22 July 2024 (11:53:34 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1711.v1

Dermatological Neoplastic Diseases Complicating Treatment with Monoclonal Antibody for Multiple Sclerosis

Floriana Bile, Maddalena Sparaco, Eleonora Ruocco, Giuseppina Miele, Elisabetta Maida, Renato Vele, Davide Mele, Simona Bonavita, Luigi Lavorgna

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Multiple Sclerosis; Skin cancer; Monoclonal antibodies.

Online: 22 July 2024 (11:47:39 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1636.v1

Microglia-Associated Neuroinflammation in Alzheimer’s Disease

Siddharth Shah, Hritvik Jain

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: microglia; alzheimers disease; neurosurgery; neurology; neuroglia

Online: 22 July 2024 (05:05:07 CEST)

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Background: Neuroinflammation has long been implicated in the progression of amyloid beta (Aβ) accumulation and the decline of cognitive function in Alzheimer's disease (AD). Currently, many transcription factors, downstream signaling pathways, and molecular mechanisms that regulate the polarization of microglia have been explored. Furthermore, microglia may also exert a complex role in AD through the transformation of Aβ plaques or debris clearance, reflected in Aβ phagocytosis. One of the mediators of neuroinflammation in AD is the activated microglia. Therefore, the regulation of microglial function may be the key to successfully treating AD. Methods: This is a review article. PubMed, Embase, Scopus, and research meeting abstracts were searched up to 2024 for studies of microglia and neuroinflammation in Alzheimer's Disease. Systematic information retrieval was performed and appropriate studies were isolated based on important information available in the studies. The information from each of the articles was un-derstood and extracted to form a database. Results: The similar neuropathological results between several animals and AD cases show the possibility to implement microglia-related changes as an earlier diagnostic marker for AD in humans. The gene sets identified in various transcriptomic studies further foster this avenue of research by offering potential targets for therapeutic development. Multiple studies suggest that microglia-associated neuroinflammation at a special stage could also be protective, and there-fore, intervention should be delicate so that a beneficial response is retained. Conclusion: The phenotype balance between A1 (toxic) and A2 (safe) microglial phenotypes to toxic illness in AD has become a hot research topic at present. Substantial evidence, both in vitro and in vivo, has suggested that the loss of the normal A2 phenotype and the activation of toxic A1 microglia contribute to neurodegeneration in AD. Promoting or restoring the polarization of mi-croglia towards the A2 phenotype may thus represent an effective therapeutic strategy for ame-liorating neuroinflammation and progressive neurocognitive impairments.

Preprint ARTICLE | doi:10.20944/preprints202407.1556.v1

Effects of Ketogenic Diet on Increased Ethanol Consumption Induced by Social Stress in Female Mice

Laura Torres-Rubio, Marina D Reguilón, Susana Mellado, María Pascual, Marta Rodriguez-Arias

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: ketogenic diet; social stress; ethanol; female; mice

Online: 19 July 2024 (11:00:33 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1493.v1

Lactylation: A Novel Post-Translational Modification with Clinical Implications in CNS Diseases

Junyan Liu, Fengyan Zhao, Yi Qu

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: lactylation; epigenetics; neurodevelopment; central nervous system diseases; therapeutic target

Online: 19 July 2024 (02:26:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1419.v1

Adherence to Continuous Positive Airway Pressure Therapy (CPAP) in Patients With Obstructive Sleep Apnea (OSA): A Prospective Single-Centre Study Assessing Impact on Quality of Life and the Cues to CPAP Use

Karla Milinovic, Ivana Pavlinac Dodig, Linda Lusic Kalcina, Renata Pecotic, Natalija Ivkovic, Maja Valic, Zoran Dogas

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: obstructive sleep apnea; OSA; severe OSA; CPAP; adherence; quality of life

Online: 17 July 2024 (11:18:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1181.v1

Clinical Features and Disease Progression in Older Individuals With Rett Syndrome

Jeffrey L. Neul, Timothy A. Benke, Eric D. Marsh, Bernhard Suter, Cary Fu, Robin C. Ryther, Steven A. Skinner, David N. Lieberman, Timothy Feyma, Arthur Beisang, Peter Heydemann, Sarika U. Peters, Amitha Ananth, Alan K. Percy

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Rett syndrome; MECP2; old age; clinical severity; disease progression

Online: 15 July 2024 (19:52:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0932.v1

Morphological Alterations and Neurochemical Responses in Lead (Pb) Intoxication in Rats: Prophylactic Potentials of Luteolin

Leviticus Oghenevurinrin Arietarhire, Aisha Iyabo Ayuba, Keji- Salmat Temilola Keji-Taofik, Evi Ndudi Imonikosaye, Joseph Igbo Enya, Olushola Oladapo Oluyomi, Ukwubile Ileje Inelo, Emmanuel Oliseh Ikechuku, Olanrewaju John Afees, Ezekiel Abiola Olugbogi

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Neuroanatomy; lead toxicity; prophylactic potentials of luteolin; neurodegeneration

Online: 12 July 2024 (09:28:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0894.v1

Preservation of Vocal Function in Amyotrophic Lateral Sclerosis (ALS) Patients Following Percutaneous Dilatational Tracheostomy (PDT) and Adjuvant Therapies

Jae-Kook Yoo, Soon-Hee Kwon, Sul-Hee Yoon, Jung-Eun Lee, Je-Hyeok Jung, Jong-Eun Jun, Sang-Yoon Lee

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Percutaneous Dilatational Tracheostomy (PDT); placenta extract injection therapy; low-frequency electrical stimulation; respiratory rehabilitation; swallowing rehabilitation therapy

Online: 11 July 2024 (12:30:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0450.v2

Amantadine for Traumatic Brain Injury – Supporting Evidence and Mode of Action

Andrzej Dekundy, Gerald Pichler, Reda El Badry, Astrid Scheschonka, Wojciech Danysz

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: traumatic brain injury; clinical; preclinical; mechanism of action; sigma-1; aromatic amino acids decarboxylase; GDNF; NMDA receptors

Online: 11 July 2024 (12:28:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0878.v1

Gustatory-Visual Interaction in Human Brain Cortex: fNIRS Study

Karolina Jezierska, Aneta Cymbaluk-Płoska, Justyna Zaleska, Wojciech Podraza

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: fNIRS; taste stimulation; human brain cortex; gustatory-visual interaction

Online: 11 July 2024 (10:00:50 CEST)

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Background: many studies, on for example taste-visual dissonance, have shown that the influence of the visual cortex on taste sensation is enormous. The aim of the presented work is to investigate, using fNIRS, whether a taste stimulus, in this case the taste of bitter, also causes stimulation of the visual cortex in fNIR study. Methods: 51 participants (204 examinations, 9 996 records) were examined with fNIRS, which collects signals from whole left hemisphere. Differences between the maximum and minimum changes in oxyHb concentrations (ΔoxyHb) for the areas of the brain cortex considered responsible for recording visual and gustatory signals were analyzed. Protocol I, II, III and IV – activation with distillate water, coffee with lower concentration, reference (no stimulation) and coffee with higher concentration respectively, were used. Results: We recorded high signals for teste activation on channels covered gustatory cortex, which confirms the correctness of the choice of research method. What seems important, and somewhat surprising, is the fact that we also received high signals for the channels 45-49, which cover the visual cortex. The statistical analysis does not show any statistical differences between the protocols I, II and IV (different taste activation – water, coffee A and coffee B) for specific channels. As a results of the analysis of the correlation between the subjective bitterness assessment solutions, and the signal ΔoxyHb height, it was observed that statically important correlation, although weak, occurs only for 14 and gustatory channels, only for coffee with a higher concentration. Additionally we recorded the only statistically significant difference between women and men for protocol I (water), where the ΔoxyHb signal was twice as high for women. Conclusions: In conclusion, we can clearly state that the senses of sight and taste work closely together. Moreover, this cooperation is not one-sided - not only the visual activation affects the perception of taste, but interestingly, the taste stimulus can generate a hemodynamic response - activity in the visual cortex.

Preprint ARTICLE | doi:10.20944/preprints202407.0645.v1

Functional Interaction of KATP and BK Channels With Aquaporin-4 in the U87 Glioblastoma Cell

Fatima Maqoud, Laura Simone, Domenico Tricarico, Giulia Maria Camerino, Marina Antonacci, Grazia Paola Nicchia

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Glioblastoma; BK channels; KATP channels; Aquaporin-4; M1-AQP4 (AQP4-tetramers forming isoform); M23-AQP4 (AQP4-OAPs forming isoform); Cell cycle.

Online: 9 July 2024 (13:10:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0723.v1

Maresin-like 1 Ameliorates Neuropathology of Alzheimer's Disease in Brains of a Transgenic Mouse Model

Pallavi Shrivastava, Yan Lu, Shanchun Su, Yuichi Kobayashi, Yuhai Zhao, Nathan Lien, Abdul-Razak Masoud, Walter J Lukiw, Song Hong

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Maresin-like; Alzheimer's Disease; neuroinflammation; neuropathogenesis; amyloid-β (Aβ ); cholinergic neuron; cleaved-caspase-3; M1 or M2 microglia; A1 or A2 astrocytes; N1 or N2 neutrophil

Online: 9 July 2024 (12:24:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.0690.v1

Image-Guided Mesenchymal Stem Cell Sodium Iodide Symporter (NIS) Radionucleotide Therapy for Glioblastoma

Siddharth Shah, Brandon Lucke-Wold

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Glioblastoma; targeted radionuclide therapy; Neurosurgery; brain tumor; cancer

Online: 9 July 2024 (05:45:15 CEST)

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Background: Glioblastoma (GBM) is a highly aggressive, invasive, and growth-factor-independent grade IV glioma. Survival following the diagnosis is generally poor, with a median survival of approximately 15 months, and it is considered the most aggressive and lethal central nervous system tumor. Conventional treatments based on surgery, chemotherapy, and radiation therapy only delay progression, and death is inevitable. Malignant glioma cells are resistant to traditional therapies, potentially due to a subpopulation of glioma stem cells that are invasive and capable of rapid regrowth. Methods: Systematic retrieval of information was performed on PubMed. Specified keywords were used in PubMed and the articles published in peer-reviewed scientific journals were associated with brain GBM cancer, sodium iodide symporter (NIS). Additionally, the words 'radionuclide therapy', 'radioiodine', 'iodine-131', 'molecular imaging', 'gene therapy', and 'translational imaging' were used. Other keywords such as ‘glioblastoma', 'targeted', 'theranostic', 'symporter', 'virus', 'solid tumor', 'combined therapy', 'pituitary', or 'plasmid' were also used in appropriate literature databases and search engines. 19 articles were found in this search on Mesenchymal Stem Cell Sodium Iodide Symporter and GBM. \ These articles were from the years 2000 to 2024. Appropriate studies were isolated, and important information from each of them was understood and entered into a database from which the information was used in this article. Results: For as long as they express functional NIS, mesenchymal stem cells systemically repress T and B cells; however, after that, they are largely replaced by mesenchymal stem cells generated from embryonic stem cells that are functionally competent. As a result of their natural capacity to identify malignancies, MSC are employed as tumor therapy vehicles. Because MSCs may be transplanted in several methods, they have been proposed as ideal vehicles for NIS gene transfer. Conclusion: Non-invasive imaging-based detection of glioma stem cells presents an alternate means to monitor the tumor and diagnose and evaluate recurrence. The sodium iodine symporter gene is a specific gene in a variety of human thyroid disease that functions to move iodine into the cell. In recent years, an increasing number of studies related to the sodium iodide symporter gene have been reported in a variety of tumors and as therapeutic vectors for imaging and therapy. Gene therapy and nuclear medicine therapy for GBM provide a new direction.

Preprint ARTICLE | doi:10.20944/preprints202407.0434.v1

Inhibition of Protease Activated Receptor-2 Activation in Parkinson’s Disease

Santina Quarta, Michele Sandre, Mariagrazia Ruvoletto, Marta Campagnolo, Aron Emmi, Alessandra Biasiolo, Patrizia Pontisso, Angelo Antonini

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Neuroinflammation; Microglia; Neurodegenerative diseases; PAR2 inhibition

Online: 4 July 2024 (11:05:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0408.v1

Phase separation of SARS-CoV-2 nucleocapsid protein with TDP-43 is dependant on C-terminus domains

Michael J Strong, Crystal McLellan, Brianna Kalpanis, Cristian A Droppelmann, Murray Junop

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: neurodegeneration; biomolecular condensates; nucleocapsid protein; RNA binding proteins; amyotrophic lateral sclerosis

Online: 4 July 2024 (08:32:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0383.v1

Harnessing Artificial Neural Networks for Spinal Cord Injury Prognosis

Federica Tamburella, Emanuela Lena, Marta Mascanzoni, Marco Iosa, Giorgio Scivoletto

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: spinal cord injury; outcome; prognosis; artificial neural networks

Online: 4 July 2024 (05:57:49 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202407.0355.v1

A Novel de Novo Missense Mutation in KIF1A Associated with Young-Onset Upper-Limb Amyotrophic Lateral Sclerosis

Emilien Bernard, Florent Cluse, Adrien Bohic, Marc Hermier, Cédric Raoul, Pascal Leblanc, Claire Guissart

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Amyotrophic Lateral Sclerosis; Genome sequencing; KIF1A; de novo mutation

Online: 3 July 2024 (15:27:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1966.v1

Rasagiline Confers Neuroprotection to PC12 Cell Cultures Exposed to Oxygen-Glucose Deprivation/Reoxygenation Insult by Activating the Akt/Nrf2 Redox-Signaling Pathway and by Decreasing the Nuclear Translocation of Glyceraldehyde-3-Phosphate Dehydroge

Shimon Lecht, Adi Lahiani, Michal Klazas, Majdi Saleem Naamneh, Limor Rubin, Jiayi Dong, Wenhua Zheng, Philip Lazarovici

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Akt; cell death; GAPDH; ischemia-like insult; neuroprotection; Nrf2; phosphorylation; Rasagiline; ROS; PC 12 neuronal model; α-synuclein; Parkinson’s disease; stroke

Online: 1 July 2024 (08:40:53 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202406.1985.v1

Case Report: Molecular analyses of cell cycle-related genes in cortical brain tissue of a Rasmussen Encephalitis patient

João Ismael Budelon Gonçalves, Vinicius Rosa de Castro, William Alves Martins, Fernando Antonio Costa Xavier, Jaderson Costa da Costa, Eliseu Paglioli Neto, André Palmini, Daniel Rodrigo Marinowic

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Rasmussen’s encephalitis; Rasmussen; cell cycle; inflammatory; encephalopathy; BDNF; brain-derived neurotrophic factor; qPCR; array; cytokines.

Online: 28 June 2024 (14:18:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.2001.v1

The Brain Region Specific Citrullinome and PAD 1-6 Isozyme Detection in a Pre-motor Parkinson’s Disease Rat Model

Audrey Mercer, Marco Sancandi, Amy Maclatchy, Sigrun Lange

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: peptidylarginine deiminase (PAD); citrullination/deimination; Parkinson’s disease; brain; cortex; hippocampus; midbrain; striatum; cerebellum; olfactory bulb; KEGG

Online: 28 June 2024 (10:50:47 CEST)

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The detection of early biomarkers and molecular mechanisms in Parkinson’s disease (PD) remains a challenge. Recent research has pointed to potential roles for peptidylarginine deiminases (PADs), a family of calcium activated enzymes, and associated post-translational protein citrul-lination/deimination in early stages of the disease, with a focus on hippocampal and cortex re-gions of the brain. Further analysis of brain region specific changes in PAD isozymes and identi-fication of brain-region specific citrullinomes, therefore remain to be studied. This study assessed brain-region specific PAD isozyme expression (PADs 1-4; PAD6) and associated citrullinated protein targets in the 6-hydroxydopamine (6-OHDA) induced rat model of pre-motor PD. Cortex, hippocampus, striatum, midbrain, cerebellum and olfactory bulb were compared between con-trols/shams and the PD model. In cortex, a significant increase of PAD2 and PAD3 was observed in the PD model. In hippocampus, PAD3, PAD4 and PAD6 showed strongest levels, but with no significant changes observed between PD and controls. In striatum, a significant reduction in all PAD isozymes was observed in the PD model. In the olfactory bulb, PAD3 was significantly el-evated in PD. In midbrain, PAD2, PAD4 and PAD6 showed strongest signal but with no signifi-cant changes between PD and controls. In cerebellum, a significant increase was seen in PAD3, PAD4 and PAD6 in the PD model. Citrullinated protein hits were most abundant in cortex and hippocampus, while for the PD model an increase in citrullinated hits was particularly observed in cortex and cerebellum, compared to controls. For all brain regions there was a considerable difference in citrullinated protein IDs between the PD model and the controls. Citrullinome as-sociated KEGG pathways differed in the six brain regions; some were overlapping for controls and PD, some were identified for the PD model only, and some were identified in control brains only. KEGG pathways identified in PD brains onlywere: “Axon guidance”; “Spinocerebellar ataxia”; “Hippo signalling pathway”; “NOD-like receptor signalling pathway”; “Phosphatidyl-inositol signalling system”; “Rap1 signalling pathway”; “Platelet activation”; “Yersinia infection”; “Fc gamma R-mediated phagocytosis”; “Human cytomegalovirus infection”; “Inositol phosphate metabolism”; “Thyroid hormone signalling pathway”; “Progesterone-mediated oocyte matura-tion”; “Oocyte meiosis”; and “Choline metabolism in cancer”. Our findings highlight differences in PAD isozymes, citrullinated proteins and associated KEGG pathways between brain regions, in pre-motor PD.

Preprint ARTICLE | doi:10.20944/preprints202406.1964.v1

Aneurysmal Wall Enhancement of Non-ruptured Intracranial Aneurysms after Endovascular Treatment Correlates with Higher Aneurysm Reperfusion Rates, but Only in Large Aneurysms

Valentin Ladenhauf, Malik Galijasevic, Milovan Regodic, Raimund Helbok, Verena Rass, Christian Freyschlag, Ondra Petr, Johannes Deeg, Leonhard Gruber, Stephanie Mangesius, Elke Ruth Gizewski, Astrid Ellen Grams

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: neuroradiology; aneurysm; reperfusion

Online: 27 June 2024 (15:32:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1816.v1

Endoplasmic Reticulum Stress Differently Modulates the Release of IL-6 and IL-8 Cytokines in Human Glial Cells

Paulina Sokołowska, Anna Wiktorowska-Owczarek, Jakub Tambor, Sebastian Gawlak-Socka, Edward Kowalczyk, Marta Jóźwiak-Bębenista

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: astrocytes; microglia; tunicamycin; ER stress; proinflammatory cytokines

Online: 26 June 2024 (08:31:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1792.v1

Impaired Peripheral Vascular Function Following Ischemic Stroke: Implications for Blood Pressure Variations in the Post-stroke Patient

Gokhan Yilmaz, J. Steven Alexander

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Ischemic Stroke; Blood Pressure; Hypertension; Hypotension; Vasodilation; Vasoconstriction; Peripheral Vessels; Myography; alpha-adrenergic receptors; middle cerebral artery occlusion

Online: 26 June 2024 (05:14:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1719.v1

Modeling Neural Network Demyelination: Insights into Multiple Sclerosis Pathophysiology and Symptom Correlation

Richard Montgomery

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Multiple Sclerosis; Computational Model; Neural Networks

Online: 25 June 2024 (10:10:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1707.v1

Tetramethylpyrazine Nitrone (TBN) Reduces Amyloid β Deposition in Alzheimer's Disease Models by Modulating APP Expression, BACE1 Activity, and Autophagy Pathways

Xinhua Zhou, Zeyu Zhu, Shaoming Kuang, Kaipeng Huang, Yueping Li, Yuqiang Wang, Haiyun Chen, Maggie Pui Man Hoi, Benhong Xu, Xifei Yang, Zaijun Zhang

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Amyloid β ; Amyloid precursor protein; MicroRNA

Online: 24 June 2024 (15:36:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1627.v1

Cholinesterase Inhibition and Antioxidative Capacity of New Heteroaromatic Resveratrol Analogs: Synthesis and Physico-Chemical Properties

Milena Mlakić, Ilijana Odak, Danijela Barić, Ivana Šagud, Stanislava Talić, Irena Škorić

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: ADME; antioxidative activity; cholinesterase inhibition; docking; genotoxicity; resveratrol; thi-azole; thiophene

Online: 24 June 2024 (12:05:11 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202406.1544.v1

Maria Ljungström, Elisa Oltra, Marta Pardo

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: CFS (chronic fatigue syndrome), POTS (postural orthostatic tachycardia syndrome), stress, (COMT) catechol-O-methyltransferase, adrenaline, inflammation, AMPT (alpha-methyl-p-tyrosine)

Online: 21 June 2024 (14:43:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1449.v1

Controlled Hypoxia Acutely Prevents Physical Inactivity-Induced Peripheral BDNF Decline

Yves Duderstadt, Stefanie Schreiber, Johannes Burtscher, Lutz Schega, Notger G. Müller, Tanja Brigadski, Rüdiger Braun-Dullaeus, Volkmar Leßmann, Patrick Müller

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: BDNF; hypoxia; physical inactivity; cognition

Online: 20 June 2024 (12:59:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1389.v1

Hyperglycemia Stimulates the Irreversible Catabolism of Branched-Chain Amino Acids and Generation of Ketone Bodies by Cultured Human Astrocytes

Eduard Gondas, Eva Baranovicova, Jakub Šofranko, Radovan Murin

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: astrocyte; proton-nuclear magnetic resonance; amino acids; branched-chain 2-oxo acid; branched-chain amino acid; leucine; isoleucine; valine; euglycemia; hyperglycemia; ketone body; metabolomics

Online: 20 June 2024 (08:30:55 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.1373.v1

Glioblastoma Standard of Care: Effects on Tumor Evolution and Reverse Translation in Preclinical Models

Louis T. Rodgers, John L Villano, Anika MS Hartz, Björn Bauer

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: glioblastoma; standard of care; resection; radiation therapy; temozolomide; recurrent tumor; reverse translation; preclinical models

Online: 20 June 2024 (03:29:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1309.v1

Preoperative Cortical Mapping for Brain Tumor Surgery Using Navigated Transcranial Stimulation: Analysis of Accuracy

Wellingson Silva Paiva, Erich Talamoni Fonoff, Rhuann Silva, Lucas Schiavao, André Russowsky Brunoni, César Cimonari, Carlos Carlotti Júnior

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: brain neoplasms; motor cortex; transcranial magnetic stimulation

Online: 19 June 2024 (05:53:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.1159.v1

The Clinical Utility of Molecular Imaging Using Nuclear Medicine Tools in the Management of All Stages of Adult Gliomas

Tebatso Moshoeu Boshomane, Mankgopo Maggie Kgatle, Febin Joseph, Llewellyn Padayachy, Meshack Bida, Thomas Ebenhan, Mariza Vorster, Mike Machaba Sathekge

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: RGD; Integrins; PET; αvβ3; Gliomas; Nuclear Medicine; MRI; Neurosurgery, Angiogenesis; Molecular

Online: 17 June 2024 (13:01:02 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202406.1071.v1

A Case of Autoimmune Acute Disseminated Encephalomyelitis in an Adult Female with Systemic Lupus Erythematosus

Yousuf Sherwani, Ayham Alsaab, Mohan Sengodan

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: autoimmune diseases; demyelinating; brain; anti dna antibodies; rituximab; IVIG

Online: 17 June 2024 (08:34:45 CEST)

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Medicine and Pharmacology