Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses (Q24291066)

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Y Zhang

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J F Tobin

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D V Erbe

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S Ikemizu

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S J Davis

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M L Stahl

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J Seehra

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W S Somers

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L Mosyak

CD28/B7 system of T cell costimulation

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language of work or name

English

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publication date

29 March 2001

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published in

Nature

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volume

410

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issue

6828

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page(s)

608-11

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cites work

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CD28/B7 costimulation: a review

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Transplantation of anergic histoincompatible bone marrow allografts

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Blockade of T lymphocyte costimulation with cytotoxic T lymphocyte-associated antigen 4-immunoglobulin (CTLA4Ig) reverses the cellular pathology of psoriatic plaques, including the activation of keratinocytes, dendritic cells, and endothelial cells

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Cytoskeletal polarization and redistribution of cell-surface molecules during T cell antigen recognition

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The immunological synapse: a molecular machine controlling T cell activation

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Molecular basis of T cell inactivation by CTLA-4

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Structure of murine CTLA-4 and its role in modulating T cell responsiveness

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Solution structure of human CTLA-4 and delineation of a CD80/CD86 binding site conserved in CD28

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Structure and dimerization of a soluble form of B7-1

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The CCP4 suite: programs for protein crystallography

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CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics

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Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28

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Crystal structure at 2.8 A resolution of a soluble form of the cell adhesion molecule CD2

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Crystal structure of the extracellular region of the human cell adhesion molecule CD2 at 2.5 A resolution

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Structure of a heterophilic adhesion complex between the human CD2 and CD58 (LFA-3) counterreceptors

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Dimeric structure of the coxsackievirus and adenovirus receptor D1 domain at 1.7 A resolution

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Shape complementarity at protein/protein interfaces

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Structure of the complex between human T-cell receptor, viral peptide and HLA-A2

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Crystal structure of an NK cell immunoglobulin-like receptor in complex with its class I MHC ligand

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Structural basis of cell-cell adhesion by cadherins

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CD2 and the nature of protein interactions mediating cell-cell recognition

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Blockade of T cell activation using a surface-linked single-chain antibody to CTLA-4 (CD152).

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Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1

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Processing of X-ray diffraction data collected in oscillation mode

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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