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Solute carrier family 6 member 4 (Q28557795)

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mammalian protein found in Rattus norvegicus

Solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter)
5HTT
5HT transporter
solute carrier family 6 (neurotransmitter transporter), member 4
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Slc6a4
serotonin transporter
solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter)
sodium-dependent serotonin transporter

Language	Label	Description	Also known as
English	Solute carrier family 6 member 4	mammalian protein found in Rattus norvegicus	Solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter) 5HTT 5HT transporter solute carrier family 6 (neurotransmitter transporter), member 4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Slc6a4 serotonin transporter solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter) sodium-dependent serotonin transporter

Statements

1 reference

25 May 2022

UniProt protein ID

Sodium:neurotransmitter symporter

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P31652

Sodium:neurotransmitter symporter superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P31652

Sodium:neurotransmitter symporter, serotonin, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

neurotransmitter:sodium symporter activity

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

serotonin:sodium symporter activity

determination method

7 references

14 February 2019

Serotonin transporter binding increases in caudate-putamen and nucleus accumbens after neonatal 6-hydroxydopamine lesions in rats: implications for motor hyperactivity

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

14 February 2019

Cysteine-scanning mutagenesis of serotonin transporter intracellular loop 2 suggests an alpha-helical conformation

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

14 February 2019

Regulation of the serotonin transporter by interacting proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

monoamine transmembrane transporter activity

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

symporter activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

determination method

reason for deprecated rank

only sourced by retracted paper

1 reference

9 May 2019

Glycosyl modification facilitates homo- and hetero-oligomerization of the serotonin transporter. A specific role for sialic acid residues

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

cocaine binding

determination method

1 reference

9 May 2019

Cysteine-scanning mutagenesis of serotonin transporter intracellular loop 2 suggests an alpha-helical conformation

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

protein homodimerization activity

determination method

1 reference

9 May 2019

Glycosyl modification facilitates homo- and hetero-oligomerization of the serotonin transporter. A specific role for sialic acid residues

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

metal ion binding

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

nitric-oxide synthase binding

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

actin filament binding

determination method

1 reference

9 May 2019

Role of C-terminal region in the functional regulation of rat serotonin transporter (SERT)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

serotonin binding

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

serotonin:sodium symporter activity

determination method

6 references

9 May 2019

Serotonin transporter binding increases in caudate-putamen and nucleus accumbens after neonatal 6-hydroxydopamine lesions in rats: implications for motor hyperactivity

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

9 May 2019

Cysteine-scanning mutagenesis of serotonin transporter intracellular loop 2 suggests an alpha-helical conformation

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

9 May 2019

Regulation of the serotonin transporter by interacting proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

plasma membrane

determination method

6 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

9 May 2019

Oligomerization of serotonin transporter and its functional consequences

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

9 May 2019

Regulation of the serotonin transporter by interacting proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

9 May 2019

Role of C-terminal region in the functional regulation of rat serotonin transporter (SERT)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

integral component of plasma membrane

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

endosome membrane

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

endomembrane system

determination method

4 references

9 May 2019

Oligomerization of serotonin transporter and its functional consequences

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

9 May 2019

Subcellular redistribution of the serotonin transporter by secretory carrier membrane protein 2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

integral component of postsynaptic membrane

determination method

1 reference

9 May 2019

Ultrastructural localization of the serotonin transporter in limbic and motor compartments of the nucleus accumbens

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

integral component of presynaptic membrane

determination method

1 reference

9 May 2019

Ultrastructural localization of the serotonin transporter in limbic and motor compartments of the nucleus accumbens

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

serotonergic synapse

determination method

1 reference

9 May 2019

Ultrastructural localization of the serotonin transporter in limbic and motor compartments of the nucleus accumbens

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

biological process

response to hypoxia

determination method

1 reference

9 May 2019

Dexfenfluramine-associated changes in 5-hydroxytryptamine transporter expression and development of hypoxic pulmonary hypertension in rats

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

serotonin transport

determination method

4 references

9 May 2019

Serotonin transporter binding increases in caudate-putamen and nucleus accumbens after neonatal 6-hydroxydopamine lesions in rats: implications for motor hyperactivity

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

9 May 2019

Cysteine-scanning mutagenesis of serotonin transporter intracellular loop 2 suggests an alpha-helical conformation

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

9 May 2019

Regulation of the serotonin transporter by interacting proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

brain development

determination method

1 reference

9 May 2019

Postnatal changes in tryptophan hydroxylase and serotonin transporter immunoreactivity in multiple brainstem nuclei of the rat: implications for a sensitive period

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

response to nutrient

determination method

1 reference

9 May 2019

A Western diet increases serotonin availability in rat small intestine

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

determination method

1 reference

9 May 2019

Effects of S-citalopram, citalopram, and R-citalopram on the firing patterns of dopamine neurons in the ventral tegmental area, N-methyl-D-aspartate receptor-mediated transmission in the medial prefrontal cortex and cognitive function in the rat

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

circadian rhythm

determination method

1 reference

9 May 2019

Selective serotonin reuptake inhibitors and raft inhibitors shorten the period of Period1-driven circadian bioluminescence rhythms in rat-1 fibroblasts

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

locomotory behavior

determination method

1 reference

9 May 2019

Serotonin transporter binding increases in caudate-putamen and nucleus accumbens after neonatal 6-hydroxydopamine lesions in rats: implications for motor hyperactivity

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

response to toxic substance

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

response to organic substance

determination method

1 reference

9 May 2019

Effects of 3,4-methylenedioxymethamphetamine (MDMA) on serotonin transporter and vesicular monoamine transporter 2 protein and gene expression in rats: implications for MDMA neurotoxicity

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

positive regulation of gene expression

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

positive regulation of serotonin secretion

determination method

1 reference

9 May 2019

Reduced cocaine-induced serotonin, but not dopamine and noradrenaline, release in rats with a genetic deletion of serotonin transporters

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

monoamine transport

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

negative regulation of cerebellar granule cell precursor proliferation

determination method

1 reference

9 May 2019

Fluoxetine-induced proliferation and differentiation of neural progenitor cells isolated from rat postnatal cerebellum

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

negative regulation of synaptic transmission, dopaminergic

determination method

1 reference

9 May 2019

Effects of S-citalopram, citalopram, and R-citalopram on the firing patterns of dopamine neurons in the ventral tegmental area, N-methyl-D-aspartate receptor-mediated transmission in the medial prefrontal cortex and cognitive function in the rat

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

response to estradiol

determination method

1 reference

9 May 2019

Estradiol increases Pet-1 and serotonin transporter mRNA in the midbrain raphe nuclei of ovariectomized rats

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

social behavior

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

vasoconstriction

determination method

1 reference

9 May 2019

Potentiation of 5-hydroxytryptamine (5-HT) responses by a 5-HT uptake inhibitor in pulmonary and systemic vessels: effects of exposing rats to hypoxia

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

determination method

1 reference

9 May 2019

The serotonin transporter plays an important role in male sexual behavior: a study in serotonin transporter knockout rats

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

negative regulation of neuron differentiation

determination method

1 reference

9 May 2019

Fluoxetine-induced proliferation and differentiation of neural progenitor cells isolated from rat postnatal cerebellum

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

positive regulation of cell cycle

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

negative regulation of organ growth

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

brain morphogenesis

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

protein complex oligomerization

determination method

1 reference

9 May 2019

Oligomerization of serotonin transporter and its functional consequences

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

protein homooligomerization

determination method

1 reference

9 May 2019

Glycosyl modification facilitates homo- and hetero-oligomerization of the serotonin transporter. A specific role for sialic acid residues

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

serotonin uptake

determination method

5 references

9 May 2019

Glycosyl modification facilitates homo- and hetero-oligomerization of the serotonin transporter. A specific role for sialic acid residues

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

9 May 2019

Role of C-terminal region in the functional regulation of rat serotonin transporter (SERT)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

9 May 2019

Regulating the conducting states of a mammalian serotonin transporter

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

transmembrane transport

determination method

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

cellular response to retinoic acid

determination method

1 reference

9 May 2019

13-cis-Retinoic acid alters intracellular serotonin, increases 5-HT1A receptor, and serotonin reuptake transporter levels in vitro

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

cellular response to organic substance

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

cellular response to cGMP

determination method

1 reference

9 May 2019

Phosphorylation of threonine residue 276 is required for acute regulation of serotonin transporter by cyclic GMP

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31652

determination method

Sodium:neurotransmitter symporter, serotonin, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P31652

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSRNOP00000004717

1 reference

ensembl Release 106

Ensembl protein ID

ENSRNOP00000004717

Sitelinks

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