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Cyclin dependent kinase 10 (Q5198248)

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mammalian protein found in Homo sapiens

cyclin-dependent kinase related protein
cyclin-dependent kinase 10
cell division protein kinase 10
serine/threonine protein kinase PISSLRE
Serine/threonine-protein kinase PISSLRE
CDK10
cyclin-dependent kinase (CDC2-like) 10
CDC2-related protein kinase

Language	Label	Description	Also known as
English	Cyclin dependent kinase 10	mammalian protein found in Homo sapiens	cyclin-dependent kinase related protein cyclin-dependent kinase 10 cell division protein kinase 10 serine/threonine protein kinase PISSLRE Serine/threonine-protein kinase PISSLRE CDK10 cyclin-dependent kinase (CDC2-like) 10 CDC2-related protein kinase

Statements

1 reference

13 November 2019

UniProt protein ID

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15131

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15131

determination method

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15131

determination method

protein kinase activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15131

determination method

cyclin-dependent protein kinase activity

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15131

determination method

protein binding

determination method

4 references

8 April 2019

STAR syndrome-associated CDK10/Cyclin M regulates actin network architecture and ciliogenesis.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15131

determination method

8 April 2019

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15131

determination method

8 April 2019

Proyl isomerase Pin1 facilitates ubiquitin-mediated degradation of cyclin-dependent kinase 10 to induce tamoxifen resistance in breast cancer cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15131

determination method

8 April 2019

Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15131

determination method

determination method

2 references

kinase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15131

determination method

cyclin-dependent protein serine/threonine kinase activity

determination method

3 references

8 April 2019

Molecular cloning of PISSLRE, a novel putative member of the cdk family of protein serine/threonine kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15131

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15131

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15131

determination method

mediator complex

determination method

1 reference

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15131&geneProductId=UniProtKB:Q15131

determination method

ciliary basal body

determination method

1 reference

8 April 2019

STAR syndrome-associated CDK10/Cyclin M regulates actin network architecture and ciliogenesis.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15131

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15131

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15131

determination method

cell projection

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15131

determination method

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15131

determination method

biological process

traversing start control point of mitotic cell cycle

determination method

1 reference

8 April 2019

PISSLRE, a human novel CDC2-related protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15131

determination method

phosphorylation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15131

determination method

positive regulation of MAPK cascade

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15131

determination method

negative regulation of cell population proliferation

determination method

1 reference

8 April 2019

PISSLRE, a human novel CDC2-related protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15131

determination method

peptidyl-threonine phosphorylation

determination method

1 reference

8 April 2019

STAR syndrome-associated CDK10/Cyclin M regulates actin network architecture and ciliogenesis.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15131

determination method

regulation of actin cytoskeleton organization

determination method

1 reference

8 April 2019

STAR syndrome-associated CDK10/Cyclin M regulates actin network architecture and ciliogenesis.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15131

determination method

negative regulation of cilium assembly

determination method

1 reference

8 April 2019

STAR syndrome-associated CDK10/Cyclin M regulates actin network architecture and ciliogenesis.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15131

determination method

cell projection organization

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15131

determination method

physically interacts with

object of statement has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL445813

object of statement has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL488436

Gene Atlas image

PBB GE CDK10 203469 s at fs.png
732 × 530; 12 KB

0 references

http://purl.uniprot.org/uniprot/Q15131

1 reference

Identifiers.org

serine/threonine-protein kinase, active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15131

protein kinase, ATP binding site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15131

protein kinase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15131

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000338673

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000338673

ENSP00000424415

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000424415

ENSP00000484357

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000484357

ENSP00000329957

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000329957

ENSP00000421597

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000421597

ENSP00000423370

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000423370

ENSP00000426102

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000426102

ENSP00000426264

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000426264

ENSP00000455976

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000455976

ENSP00000456788

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000456788

ENSP00000457055

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000457055

ENSP00000486594

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000486594

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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