Nicastrin (Q7024546)

http://www.ebi.ac.uk/interpro/protein/Q92542

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

7 references

8 April 2019

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

8 April 2019

Cellular localization of Nicastrin affects amyloid beta species production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

8 April 2019

An atomic structure of human γ-secretase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

8 April 2019

Intracellular trafficking of TREM2 is regulated by presenilin 1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

8 April 2019

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

8 April 2019

TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

8 April 2019

An alternative spliced mouse presenilin-2 mRNA encodes a novel gamma-secretase inhibitor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92542&geneProductId=UniProtKB:Q92542

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92542&geneProductId=UniProtKB:Q92542

1 January 2018

Purification and characterization of the human gamma-secretase complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92542&geneProductId=UniProtKB:Q92542

3 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92542&geneProductId=UniProtKB:Q92542

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92542&geneProductId=UniProtKB:Q92542

17 October 2017

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92542&geneProductId=UniProtKB:Q92542

1 reference

17 October 2017

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92542&geneProductId=UniProtKB:Q92542

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92542&geneProductId=UniProtKB:Q92542

endoplasmic reticulum

3 references

1 January 2018

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92542&geneProductId=UniProtKB:Q92542

1 January 2018

Purification and characterization of the human gamma-secretase complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92542&geneProductId=UniProtKB:Q92542

Large-scale proteomics and phosphoproteomics of urinary exosomes

extracellular exosome

3 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92542&geneProductId=UniProtKB:Q92542

17 October 2017

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92542&geneProductId=UniProtKB:Q92542

17 October 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92542&geneProductId=UniProtKB:Q92542

integral component of membrane

5 references

8 April 2019

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

8 April 2019

Three-dimensional structure of human γ-secretase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

8 April 2019

An atomic structure of human γ-secretase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

azurophil granule membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

cytoplasmic vesicle membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

integral component of plasma membrane

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92542&geneProductId=UniProtKB:Q92542

1 January 2018

Purification and characterization of the human gamma-secretase complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92542&geneProductId=UniProtKB:Q92542

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92542&geneProductId=UniProtKB:Q92542

1 reference

8 April 2019

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

protein-containing complex

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

integral component of presynaptic membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

ephrin receptor signaling pathway

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

myeloid cell homeostasis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

4 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92542&geneProductId=UniProtKB:Q92542

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92542&geneProductId=UniProtKB:Q92542

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92542&geneProductId=UniProtKB:Q92542

17 October 2017

Purification and characterization of the human gamma-secretase complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92542&geneProductId=UniProtKB:Q92542

amyloid-beta metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

epithelial cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

1 reference

8 April 2019

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

membrane protein intracellular domain proteolysis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

positive regulation of apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

amyloid precursor protein catabolic process

1 reference

8 April 2019

Purification and characterization of the human gamma-secretase complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

neutrophil degranulation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

Notch signaling pathway

1 reference

8 April 2019

5 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92542&geneProductId=UniProtKB:Q92542

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92542&geneProductId=UniProtKB:Q92542

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92542&geneProductId=UniProtKB:Q92542

1 January 2018

Purification and characterization of the human gamma-secretase complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92542&geneProductId=UniProtKB:Q92542

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92542&geneProductId=UniProtKB:Q92542

IBA

cerebellum development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

Notch receptor processing, ligand-dependent

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

membrane protein ectodomain proteolysis

1 reference

8 April 2019

Purification and characterization of the human gamma-secretase complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

dopamine receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

glutamate receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

8 April 2019

Purification and characterization of the human gamma-secretase complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

central nervous system myelination

IBA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

amyloid precursor protein metabolic process

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

8 April 2019

Three-dimensional structure of human γ-secretase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

8 April 2019

An atomic structure of human γ-secretase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

amyloid precursor protein biosynthetic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

positive regulation of amyloid precursor protein biosynthetic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

positive regulation of catalytic activity

1 reference

8 April 2019

Purification and characterization of the human gamma-secretase complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

neuron apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

cellular response to calcium ion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

regulation of long-term synaptic potentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

short-term synaptic potentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92542

physically interacts with

1 reference

Open Targets Platform

retrieved

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1090771

1 reference

Open Targets Platform

retrieved

14 August 2023

https://platform.opentargets.org/drug/CHEMBL463981

1 reference

Open Targets Platform

retrieved

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1770916

Gene Atlas image

PBB GE NCSTN 208759 at fs.png
732 × 530; 12 KB

0 references

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

0 references

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016