Measles Immune Suppression: Lessons from the Macaque Model
Figure 1
MV infects high percentages of B-lymphocytes and CD45RA− memory T-lymphocytes.
(A–D) Macroscopic detection of EGFP in lymphoid tissues of the gastro-intestinal tract in three different macaques: mesenteric lymph nodes (A), gut-associated lymphoid tissue (GALT) (B and C), including the Peyer's patches (C and D). Panel D is an enlargement of panel C (indicated by asterisk); (E–H) MV infection percentages in lymphocyte subsets during the approximate peak viremia. T-lymphocyte subpopulations were identified as Tn (CD45RA+), TCM (CD45RA−CCR7+) or TEM (CD45RA−CCR7−), B-lymphocytes were identified as Bn (CD27−IgD+) or BM (CD27+IgD−). Box plots were chosen since the data were not normally distributed, and show the median infection percentages with the 25th–75th percentiles, error bars indicate the 10th–90th percentiles, dots the 5th–95th percentiles. The 10th–90th percentiles and 5th–95th percentiles are only shown if the number of observations is at least ten; **, P<0.01. *, P<0.05. In panel E, F and G 14 animals were included; in panel H 3 animals were included.