Measles Immune Suppression: Lessons from the Macaque Model
Figure 4
MV infection causes temporary immunological amnesia.
(A) T-lymphocyte responses to PPD and MV were measured by IFN-γ production after in vitro stimulation of PBMC collected from 4 BCG-vaccinated macaques. Measurements were performed in triplicate, graphs shows means ± SD; (B) Mantoux tests were performed 7 days before (n = 4) and 8 (n = 2) or 10 (n = 2) days after MV infection. Images were collected 3 days after intra-dermal injection with tuberculin. Before MV infection classical delayed-type hypersensitivity responses were observed, associated with diffuse swelling and redness (indicated by arrows), after MV only a small localized papule was observed (indicated by arrow). H&E and CD3 staining of the corresponding skin tissues showed infiltration of T-lymphocytes in the dermis of the pre-infection Mantoux response, which was absent after MV infection. Representative images from 4 animals are shown.