Measles Immune Suppression: Lessons from the Macaque Model
Figure 5
A model for measles immune suppression.
(A) Relative population sizes of CD4+ or CD8+ Tn, TCM and TEM in PBMC at different d.p.i., expressed as fold changes relative to 0 d.p.i. Means ± SEM of 9 animals are shown. (B). A model describing the changes in the relative size of pre-existing naive lymphocytes (blue), pre-existing memory lymphocytes (red, sum of TM and follicular B-lymphocytes) and newly induced MV-specific (and bystander) lymphocytes (green) before, during and after measles. The relative WBC counts obtained from the macaques included in this study have been overlaid (black circles, means ± SEM). Thirty-four animals were included to obtain the WBC count graph. The red line indicates the time-point of MV-infection, bars above the graph indicate the approximate period of MV viremia (green), rash (red) and immune suppression (black).