Explore the latest in pathology and laboratory medicine, including AI applications to biopsy readings, diagnostic test interpretation, and more.
This cohort study compares individuals with previous SARS-CoV-2 infection and SARS-CoV-2–naive individuals for their saliva and serum responses after infection and vaccination or vaccination alone.
This Viewpoint discusses the challenges involved with secondary health care data collection vs primary data collection and provides a list of suggested data checks before registration of a study protocol using secondary data.
This cross-sectional study investigates perioperative oxygen saturation differences in Black and White infants with single ventricles undergoing stage 1 palliation.
This cross-sectional study evaluates the association of preoperative circulating tumor HPV DNA levels with disease burden or adverse pathologic features among patients with HPV-associated oropharyngeal squamous cell carcinoma who have undergone primary transoral robotic surgery.
A man in his 40s was referred for an 8-mm red, firm, mobile nodule with irregular red lacunae and vessels and an absence of septa. What is your diagnosis?
This diagnostic study compares the performance of tuberculin skin testing and interferon-γ release assays in predicting development of tuberculosis (TB) disease in the US.
This diagnostic study evaluates the performance of a handheld mass spectrometry device used for in vivo and ex vivo molecular analysis during breast cancer operations to discriminate healthy breast tissue from invasive ductal carcinoma.
This economic evaluation investigates the cost-effectiveness of parathyroid cryopreservation and delayed autotransplantation as a treatment for permanent hypoparathyroidism as a result of thyroid/parathyroid surgery.
This randomized clinical trial evaluates the effectiveness of serum S100B measurement to reduce exposure to cranial computed tomographic scans among children admitted to the emergency department with minor head trauma.
This cohort study investigates whether there is a long-term association between the Veterans Affairs (VA) Patient-Aligned Cancer Team implementation and timely follow-up of abnormal diagnostic test results for 6 different cancers.
This randomized clinical trial evaluates a rapid syndromic polymerase chain reaction–based diagnostic test for lower respiratory tract infections in patients presenting to the emergency department.
This retrospective cross-sectional study illustrates national-level trends in immunohistochemistry staining for the diagnosis of melanoma in older adult patients enrolled in Medicare.
This systematic review and meta-analysis assesses bias and accuracy in glomerular filtration rate estimating equations across various adult populations in the US.
This survey study describes efforts to eliminate harmful race-based clinical algorithms among state or territorial medical associations and specialty societies in the US.
This case report studies a 12-year-old boy with a family history of X-linked adrenal leukodystrophy and his 8-year-old younger brother.
A patient had burning and pain in the mouth, reduced oral aperture, white-tan plaques on the oral mucosa, and thickened buccal mucosae bilaterally; biopsy of the lower labial mucosa showed subepithelial fibrosis. She had no history of cigarette smoking or use of chewing tobacco but had current and past history of chewing areca nuts. What is the diagnosis and what would you do next?
This systematic review and meta-analysis examines the association of rapid respiratory virus testing in patients with suspected acute respiratory infection with decreased antibiotic use, ancillary tests, emergency department length of stay and return visits and hospitalization, and increased influenza antiviral treatment.
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