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Production of atypical measles in rhesus macaques: evidence for disease mediated by immune complex formation and eosinophils in the presence of fusion-inhibiting antibody

Nat Med. 1999 Jun;5(6):629-34. doi: 10.1038/9473.

Abstract

The severe disease atypical measles occurred when individuals immunized with a poorly protective inactivated vaccine contracted measles, and was postulated to be due to a lack of fusion-inhibiting antibodies. Here, rhesus macaques immunized with formalin-inactivated measles vaccine developed transient neutralizing and fusion-inhibiting antibodies, but no cytotoxic T-cell response. Subsequent infection with measles virus caused an atypical rash and pneumonitis, accompanied by immune complex deposition and an increase in eosinophils. Fusion-inhibiting antibody appeared earlier in these monkeys than in non-immunized monkeys. These data indicate that atypical measles results from previous priming for a nonprotective type 2 CD4 T-cell response rather than from lack of functional antibody against the fusion protein.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibodies, Viral / immunology*
  • CD4-Positive T-Lymphocytes / metabolism
  • CD8-Positive T-Lymphocytes / metabolism
  • Eosinophilia / immunology
  • Eosinophils / immunology*
  • Female
  • Immunoglobulin A / metabolism
  • Macaca mulatta
  • Male
  • Measles / immunology*
  • Measles / pathology
  • Measles / therapy
  • Measles Vaccine / immunology*
  • Measles Vaccine / pharmacology
  • Skin / pathology
  • Vaccines, Inactivated / immunology

Substances

  • Antibodies, Viral
  • Immunoglobulin A
  • Measles Vaccine
  • Vaccines, Inactivated