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Role of CD8(+) lymphocytes in control and clearance of measles virus infection of rhesus monkeys

J Virol. 2003 Apr;77(7):4396-400. doi: 10.1128/jvi.77.7.4396-4400.2003.

Abstract

The creation of an improved vaccine for global measles control will require an understanding of the immune mechanisms of measles virus containment. To assess the role of CD8(+) cytotoxic T lymphocytes in measles virus clearance, rhesus monkeys were depleted of CD8(+) lymphocytes by monoclonal anti-CD8 antibody infusion and challenged with wild-type measles virus. The CD8(+) lymphocyte-depleted animals exhibited a more extensive rash, higher viral loads at the peak of virus replication, and a longer duration of viremia than did the control antibody-treated animals. These findings indicate a central role for CD8(+) lymphocytes in the control of measles virus infections and the importance of eliciting a cell-mediated immune response in new measles vaccine strategies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Base Sequence
  • CD8-Positive T-Lymphocytes / immunology*
  • CD8-Positive T-Lymphocytes / pathology
  • DNA, Viral / genetics
  • Disease Models, Animal
  • Humans
  • Immunity, Cellular
  • Lymphocyte Depletion
  • Macaca mulatta
  • Measles / immunology*
  • Measles / pathology
  • Measles / virology*
  • Measles Vaccine / immunology
  • Measles virus / immunology*
  • Measles virus / pathogenicity
  • Measles virus / physiology
  • RNA, Viral / genetics
  • RNA, Viral / metabolism
  • Virus Replication / immunology

Substances

  • DNA, Viral
  • Measles Vaccine
  • RNA, Viral