Abstract
Viruses can cause a severe lymphopenia early in infection and a subsequent, lasting loss of pre-existing CD8(+) memory T cells. We therefore questioned how well virus Ag-specific memory CD8(+) T cells could reconstitute mice rendered lymphopenic as a consequence of genetics, irradiation, or viral or poly(I:C)-induced cytokines. In each case, reconstitution of the CD8(+) compartment was associated with limited division of virus-specific memory T cells and a reduction in their proportion. This indicates that foreign Ag-experienced CD44(high)CD8(+) memory T cells may respond differently to homeostatic signals than other CD44(high)CD8(+) cells, and that events inducing lymphopenia may lead to a permanent reduction in T cell memory.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adoptive Transfer* / methods
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Animals
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Apoptosis / immunology
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Arenaviridae Infections / immunology
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CD8-Positive T-Lymphocytes / immunology*
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CD8-Positive T-Lymphocytes / metabolism
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CD8-Positive T-Lymphocytes / radiation effects
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CD8-Positive T-Lymphocytes / virology*
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Epitopes, T-Lymphocyte / immunology*
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Homeostasis / immunology
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Homeostasis / radiation effects
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Hyaluronan Receptors / biosynthesis
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Immunologic Memory* / radiation effects
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Lymphocyte Count
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Lymphocytic Choriomeningitis / immunology
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Lymphocytic choriomeningitis virus / immunology
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Lymphopenia / immunology*
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Lymphopenia / pathology
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Lymphopenia / virology*
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Male
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Mice
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Mice, Inbred C57BL
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Mice, Knockout
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Mice, SCID
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Pichinde virus / immunology
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Radiation Chimera
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Spleen / cytology
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Spleen / immunology
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Spleen / transplantation
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T-Lymphocyte Subsets / immunology
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T-Lymphocyte Subsets / metabolism
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T-Lymphocyte Subsets / radiation effects
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T-Lymphocyte Subsets / virology
Substances
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Epitopes, T-Lymphocyte
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Hyaluronan Receptors