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Attrition of virus-specific memory CD8+ T cells during reconstitution of lymphopenic environments

J Immunol. 2003 Jul 15;171(2):655-63. doi: 10.4049/jimmunol.171.2.655.

Abstract

Viruses can cause a severe lymphopenia early in infection and a subsequent, lasting loss of pre-existing CD8(+) memory T cells. We therefore questioned how well virus Ag-specific memory CD8(+) T cells could reconstitute mice rendered lymphopenic as a consequence of genetics, irradiation, or viral or poly(I:C)-induced cytokines. In each case, reconstitution of the CD8(+) compartment was associated with limited division of virus-specific memory T cells and a reduction in their proportion. This indicates that foreign Ag-experienced CD44(high)CD8(+) memory T cells may respond differently to homeostatic signals than other CD44(high)CD8(+) cells, and that events inducing lymphopenia may lead to a permanent reduction in T cell memory.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adoptive Transfer* / methods
  • Animals
  • Apoptosis / immunology
  • Arenaviridae Infections / immunology
  • CD8-Positive T-Lymphocytes / immunology*
  • CD8-Positive T-Lymphocytes / metabolism
  • CD8-Positive T-Lymphocytes / radiation effects
  • CD8-Positive T-Lymphocytes / virology*
  • Epitopes, T-Lymphocyte / immunology*
  • Homeostasis / immunology
  • Homeostasis / radiation effects
  • Hyaluronan Receptors / biosynthesis
  • Immunologic Memory* / radiation effects
  • Lymphocyte Count
  • Lymphocytic Choriomeningitis / immunology
  • Lymphocytic choriomeningitis virus / immunology
  • Lymphopenia / immunology*
  • Lymphopenia / pathology
  • Lymphopenia / virology*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mice, SCID
  • Pichinde virus / immunology
  • Radiation Chimera
  • Spleen / cytology
  • Spleen / immunology
  • Spleen / transplantation
  • T-Lymphocyte Subsets / immunology
  • T-Lymphocyte Subsets / metabolism
  • T-Lymphocyte Subsets / radiation effects
  • T-Lymphocyte Subsets / virology

Substances

  • Epitopes, T-Lymphocyte
  • Hyaluronan Receptors