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16 pages, 1600 KiB  
Article
Optimization of the Industrial Production Process of Tunisian Date Paste for Sustainable Food Systems
by Sana Ben Amara, Atef Lakoud, Imen Mahmoudi, Imene Ben Tekaya, Assila Amri, Ahmed Snoussi, Mondher Hachani, Sami Fattouch and Mnasser Hassouna
Processes 2024, 12(10), 2083; https://doi.org/10.3390/pr12102083 (registering DOI) - 26 Sep 2024
Abstract
The production of date paste from second-grade date fruits is a fast-growing industrial activity which promotes more sustainable food systems. The industrial date paste process is mainly dependent on the thermal treatments of hydration and drying that precede flesh crushing. These thermal treatments [...] Read more.
The production of date paste from second-grade date fruits is a fast-growing industrial activity which promotes more sustainable food systems. The industrial date paste process is mainly dependent on the thermal treatments of hydration and drying that precede flesh crushing. These thermal treatments are commonly performed industrially using steam hydration instead of water soaking and convective hot air drying, which are known to be energy-intensive operations leading to high greenhouse gas emissions. The objective of this work was to optimize, on the one hand, the operations of hydration and drying of dates at an industrial scale using a response surface Box–Behnken experimental design in order to reduce the energy consumption and, on the other hand, to assess the biochemical and microstructural properties of date paste produced under optimized conditions. Optimization was performed based on the measurements of sensory attributes, instrumental texture firmness, moisture content, water activity (aw), and color parameters (L*, a*, b*), as well as on the energy savings related to the factors of hydration duration and temperature and time of drying. The optimal conditions to ensure the highest quality of the final product and the lowest energy consumption were 9.6 min of hydration at 80 °C and 3 h of drying at 52.28 °C. The biochemical analysis of the date paste produced under the optimized process showed that it is rich in dietary fibers (9.80 ± 2.10%) and total phenols (261 ± 6.2 mg gallic acid equivalent/100 g of extract). Furthermore, the studied sample exhibited a higher antioxidant potential than the raw date material as a result of the heat-inhibitory effect of oxidases. The obtained results suggest that date paste presents a good source of natural bioactive molecules and could potentially be considered as a functional food ingredient. SEM analysis showed that the microstructural properties of date paste produced under optimal conditions may promote its quality preservation during storage. Full article
(This article belongs to the Special Issue Feature Papers in the "Food Process Engineering" Section)
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13 pages, 1100 KiB  
Article
Resection of the Inferior Vena Cava Due to Tumor Involvement Allows Long-Term Survival in Different Neoplasms
by Isabel Jaén-Torrejimeno, Diego López-Guerra, Adela Rojas-Holguín, Antonio Enrique Gómez-Martin and Gerardo Blanco-Fernández
Gastroenterol. Insights 2024, 15(4), 865-877; https://doi.org/10.3390/gastroent15040060 (registering DOI) - 26 Sep 2024
Abstract
Background: The involvement of the inferior vena cava in advanced abdominal tumors is a surgical challenge, given the high postoperative morbidity and poor long-term prognosis. Our goal was to analyze our experience, perioperative management, and results. Methods: We retrospectively evaluated short and long-term [...] Read more.
Background: The involvement of the inferior vena cava in advanced abdominal tumors is a surgical challenge, given the high postoperative morbidity and poor long-term prognosis. Our goal was to analyze our experience, perioperative management, and results. Methods: We retrospectively evaluated short and long-term results of surgical resections of tumors with associated inferior vena cava resection performed in our facilities between 2012 and 2023. Results: A total of 25 patients were selected for our retrospective study: 3 with renal carcinoma, 5 with sarcoma, 12 with metastatic lesions, 2 with adrenal tumors, 1 pancreatic tumor, 1 extra-adrenal paraganglioma and 1 with hepatocellular carcinoma. Postoperative severe complications (Dindo-Clavien score ≥ IIIa) affected 36% of patients and the mortality rate was 8%. Partial resection with primary repair was performed in 13 patients (52%), with patch reconstruction in 6 (24%), and vascular reconstruction with prosthesis in 6 patients (24%). The mean disease-free survival was 7 months (IQR 2.5–11.5). Graft thrombosis occurred in 2 patients during follow-up. Conclusions: In selected patients, the resection of the inferior vena cava is a complex surgery with an assumable morbimortality and relative survival improvement. Full article
(This article belongs to the Collection Advances in Gastrointestinal Cancer)
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14 pages, 5975 KiB  
Article
Habitat Suitability Assessment for Two Burrowing Rodents on the Island of Lesvos: A Niche-Based Approach
by Stylianos P. Zannetos, Konstantinos Theodorou, Yiannis G. Zevgolis, Eleni Galinou and Triantaphyllos Akriotis
Life 2024, 14(10), 1231; https://doi.org/10.3390/life14101231 (registering DOI) - 26 Sep 2024
Abstract
We conducted a habitat suitability assessment for two burrowing rodents, Anatolian or Nehring’s blind mole rat (Nannospalax xanthodon) and Harting’s vole (Microtus hartingi), on the island of Lesvos using a niche-based approach. We collected data on the presence of [...] Read more.
We conducted a habitat suitability assessment for two burrowing rodents, Anatolian or Nehring’s blind mole rat (Nannospalax xanthodon) and Harting’s vole (Microtus hartingi), on the island of Lesvos using a niche-based approach. We collected data on the presence of the two species across the island and selected several environmental variables, including land cover, geology, and habitat topography, to assess their influence on habitat suitability. We used the Maxent species distribution modelling algorithm to predict suitable habitats. The results showed that both species preferred habitats with low slopes and specific geological substrates, i.e., alluvial deposits and volcanic rocks. M. hartingi showed a preference for open habitats such as saltmarshes and non-irrigated arable land, while N. xanthodon preferred non-irrigated arable land, pastures, and discontinuous urban fabric. The model predicted a wider area of suitable habitats for Microtus hartingi compared to N. xanthodon. Interestingly, the two species are absent from the southeastern part of the island despite our model predicting high suitability; this indicates that a natural barrier of hilly terrain, extensive pine forests, and limestone rock formations may exist that impedes dispersal. Our study provides valuable insights into the habitat preferences of these two burrowing rodents on the island of Lesvos, which can inform biodiversity conservation and ecosystem management strategies. Full article
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17 pages, 29455 KiB  
Article
FloatingBlue: A Delay Tolerant Networks-Enabled Internet of Things Architecture for Remote Areas Combining Data Mules and Low Power Communications
by Ruan C. M. Teixeira, Celso B. Carvalho, Carlos T. Calafate, Edjair Mota, Rubens A. Fernandes, Andre L. Printes and Lennon B. F. Nascimento
Sensors 2024, 24(19), 6218; https://doi.org/10.3390/s24196218 (registering DOI) - 26 Sep 2024
Abstract
Monitoring vast and remote areas like forests using Wireless Sensor Networks (WSNs) presents significant challenges, such as limited energy resources and signal attenuation over long distances due to natural obstacles. Traditional solutions often require extensive infrastructure, which is impractical in such environments. To [...] Read more.
Monitoring vast and remote areas like forests using Wireless Sensor Networks (WSNs) presents significant challenges, such as limited energy resources and signal attenuation over long distances due to natural obstacles. Traditional solutions often require extensive infrastructure, which is impractical in such environments. To address these limitations, we introduce the “FloatingBlue” architecture. This architecture, known for its superior energy efficiency, combines Bluetooth Low Energy (BLE) technology with Delay Tolerant Networks (DTN) and data mules. It leverages BLE’s low power consumption for energy-efficient sensor broadcasts while utilizing DTN-enabled data mules to collect data from dispersed sensors without constant network connectivity. Deployed in a remote agricultural area in the Amazon region, “FloatingBlue” demonstrated significant improvements in energy efficiency and communication range, with a high Packet Delivery Ratio (PDR). The developed BLE beacon sensor achieved state-of-the-art energy consumption levels, using only 2.25 µJ in sleep mode and 11.8 µJ in transmission mode. Our results highlight “FloatingBlue” as a robust, low-power solution for remote monitoring in challenging environments, offering an energy-efficient and scalable alternative to traditional WSN approaches. Full article
(This article belongs to the Special Issue Energy Efficient Design in Wireless Ad Hoc and Sensor Networks)
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12 pages, 1610 KiB  
Article
Investigation of the Interfacial Fusion Bonding on Hybrid Additively Manufactured Components under Torsional Load
by Melike Kizak, Anna von Bartschikowski, Anna Trauth, Christian Heigl and Klaus Drechsler
Polymers 2024, 16(19), 2719; https://doi.org/10.3390/polym16192719 (registering DOI) - 26 Sep 2024
Abstract
Hybrid manufacturing processes integrate multiple manufacturing techniques to leverage their respective advantages and mitigate their limitations. This study combines additive manufacturing and injection molding, aiming to efficiently produce components with extensive design flexibility and functional integration. The research explores the interfacial fusion bonding [...] Read more.
Hybrid manufacturing processes integrate multiple manufacturing techniques to leverage their respective advantages and mitigate their limitations. This study combines additive manufacturing and injection molding, aiming to efficiently produce components with extensive design flexibility and functional integration. The research explores the interfacial fusion bonding of hybrid additively manufactured components under torsional loading. Specifically, it examines the impact of various surface treatments on injection molded parts and the influence of different build chamber temperatures during additive manufacturing on torsional strength. Polycarbonate components, neat, with glass or carbon fiber-reinforcement, are produced and assessed for dimensional accuracy, torsional strength, and fracture behavior. The findings emphasize the critical role of surface treatment for the injection molded components before additive manufacturing. Additionally, the study identifies the influence of chamber temperatures on both dimensional accuracy and torsional strength. Among all investigated materials, plasma-treated neat samples exhibited the best torsional strength. The torsional strength was increased by up to 87% by actively heating the build chamber to 186 °C for neat polycarbonate. These insights aim to advance the quality and performance of hybrid additively manufactured components, broadening their application potential across diverse fields. Full article
(This article belongs to the Topic Advanced Composites Manufacturing and Plastics Processing)
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458 KiB  
Proceeding Paper
A Hydroacoustic Model for the Identification of Incipient Cavitation: A Preliminary Study
by Renato Montillo, Maria Cristina Morani, Oreste Fecarotta and Armando Carravetta
Eng. Proc. 2024, 69(1), 172; https://doi.org/10.3390/engproc2024069172 (registering DOI) - 25 Sep 2024
Abstract
Recent research has focused on the dynamic control and regulation of hydraulic devices like pumps and turbines to enhance the efficiency of water systems. These devices are adjusted to maintain nearly optimal hydraulic conditions and operating efficiency, although achieving both can be challenging [...] Read more.
Recent research has focused on the dynamic control and regulation of hydraulic devices like pumps and turbines to enhance the efficiency of water systems. These devices are adjusted to maintain nearly optimal hydraulic conditions and operating efficiency, although achieving both can be challenging due to factors like machine type and changes in distribution patterns. Incipient cavitation, which can cause mechanical damage and reduce efficiency, presents a specific challenge. It produces a distinct noise which this study aims to detect through a proposed methodology. Using the LES WALE model in OpenFOAM and Lighthill’s acoustic analogy, this research simulates and analyzes the noise generated by the dynamic of a confined flow. This work aims to be the starting point for more complex models. Full article
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1154 KiB  
Proceeding Paper
Rapid Prototyping in Pakistan: A Technical Feasibility Study with Analytical Hierarchy Process Analysis, Bridging Civil and Industrial Engineering Perspectives
by Ghulam Ameer Mukhtar, Sana Shehzadi, Muhammad Moazzam Ali, Abdul Ahad Malik and Muhammad Mohsin Arshad
Eng. Proc. 2024, 75(1), 30; https://doi.org/10.3390/engproc2024075030 (registering DOI) - 25 Sep 2024
Abstract
This study investigates the prospect of using rapid prototyping, particularly additive manufacturing, in Pakistan’s construction and manufacturing sectors, aiming to encourage R&D by the analysis of technical feasibility of this technology and collaboration between civil and industrial engineering. To solve this puzzle, we [...] Read more.
This study investigates the prospect of using rapid prototyping, particularly additive manufacturing, in Pakistan’s construction and manufacturing sectors, aiming to encourage R&D by the analysis of technical feasibility of this technology and collaboration between civil and industrial engineering. To solve this puzzle, we collected data from field experts, academia researchers, and license holders of this technology. Further, analytical hierarchy process (AHP), a sub-branch of multicriteria decision-making method (MCDM), was used to gauge the systematically by prioritizing selection criteria for solving the problem. AHP makes the methodical process more accurate and organized, which helped us to proposed a feasibility study for the technology’s success in Pakistan’s construction and manufacturing industries. The findings show a 79.4% probability, which indicates interaction among both engineering disciplines. Furthermore, a sensitivity analysis was conducted to enhance the dependability of the AHP model, which assists in sound decision making during ambiguous conditions. Apart from economic technical aspects, sustainability plays a very crucial role in the evaluation process. This text shows the environmental effects and sustainability implications associated with the assimilation of rapid prototyping technologies. This supports the integration of rapid prototyping in Pakistan, contributing to discussions on technological innovations in emerging nations. This will also lay a foundation for future interdisciplinary collaboration and technological enrichments in both engineering domains. Full article
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15 pages, 376 KiB  
Article
A Covariance-Free Strictly Complex-Valued Relevance Vector Machine for Reducing the Order of Linear Time-Invariant Systems
by Weixiang Xie and Jie Song
Mathematics 2024, 12(19), 2991; https://doi.org/10.3390/math12192991 (registering DOI) - 25 Sep 2024
Abstract
Multiple-input multiple-output (MIMO) linear time-invariant (LTI) systems exhibit enormous computational costs for high-dimensional problems. To address this problem, we propose a novel approach for reducing the dimensionality of MIMO systems. The method leverages the Takenaka–Malmquist basis and incorporates the strictly complex-valued relevant vector [...] Read more.
Multiple-input multiple-output (MIMO) linear time-invariant (LTI) systems exhibit enormous computational costs for high-dimensional problems. To address this problem, we propose a novel approach for reducing the dimensionality of MIMO systems. The method leverages the Takenaka–Malmquist basis and incorporates the strictly complex-valued relevant vector machine (SCRVM). We refer to this method as covariance-free maximum likelihood (CoFML). The proposed method avoids the explicit computation of the covariance matrix. CoFML solves multiple linear systems to obtain the required posterior statistics for covariance. This is achieved by exploiting the preconditioning matrix and the matrix diagonal element estimation rule. We provide theoretical justification for this approximation and show why our method scales well in high-dimensional settings. By employing the CoFML algorithm, we approximate MIMO systems in parallel, resulting in significant computational time savings. The effectiveness of this method is demonstrated through three well-known examples. Full article
(This article belongs to the Special Issue Applied Mathematics in Data Science and High-Performance Computing)
28 pages, 12022 KiB  
Article
Key Synchronization Method Based on Negative Databases and Physical Channel State Characteristics of Wireless Sensor Network
by Haoyang Pu, Wen Chen, Hongchao Wang and Shenghong Bao
Sensors 2024, 24(19), 6217; https://doi.org/10.3390/s24196217 (registering DOI) - 25 Sep 2024
Abstract
Due to their inherent openness, wireless sensor networks (WSNs) are vulnerable to eavesdropping attacks. Addressing the issue of secure Internet Key Exchange (IKE) in the absence of reliable third parties like CA/PKI (Certificate Authority/Public Key Infrastructure) in WSNs, a novel key synchronization method [...] Read more.
Due to their inherent openness, wireless sensor networks (WSNs) are vulnerable to eavesdropping attacks. Addressing the issue of secure Internet Key Exchange (IKE) in the absence of reliable third parties like CA/PKI (Certificate Authority/Public Key Infrastructure) in WSNs, a novel key synchronization method named NDPCS-KS is proposed in the paper. Firstly, through an initial negotiation process, both ends of the main channels generate the same initial key seeds using the Channel State Information (CSI). Subsequently, negotiation keys and a negative database (NDB) are synchronously generated at the two ends based on the initial key seeds. Then, in a second-negotiation process, the NDB is employed to filter the negotiation keys to obtain the keys for encryption. NDPCS-KS reduced the risk of information leakage, since the keys are not directly transmitted over the network, and the eavesdroppers cannot acquire the initial key seeds because of the physical isolation of their eavesdropping channels and the main channels. Furthermore, due to the NP-hard problem of reversing the NDB, even if an attacker obtains the NDB, deducing the initial key seeds is computationally infeasible. Therefore, it becomes exceedingly difficult for attackers to generate legitimate encryption keys without the NDB or initial key seeds. Moreover, a lightweight anti-replay and identity verification mechanism is designed to deal with replay attacks or forgery attacks. Experimental results show that NDPCS-KS has less time overhead and stronger randomness in key generation compared with other methods, and it can effectively counter replay, forgery, and tampering attacks. Full article
(This article belongs to the Section Sensor Networks)
13 pages, 2813 KiB  
Article
Geometry of Non-Diffusive Tracer Transport in Gridded Atmospheric Models
by Robert McGraw and Tamanna Subba
Atmosphere 2024, 15(10), 1151; https://doi.org/10.3390/atmos15101151 (registering DOI) - 25 Sep 2024
Abstract
A first-order linear and numerically non-diffusive Eulerian transport algorithm, minVAR, was recently developed for preservation of correlations between interrelated tracers during advective transport. The present study extends this work by: (1) providing further investigation of several interesting geometric constructions found in contours of [...] Read more.
A first-order linear and numerically non-diffusive Eulerian transport algorithm, minVAR, was recently developed for preservation of correlations between interrelated tracers during advective transport. The present study extends this work by: (1) providing further investigation of several interesting geometric constructions found in contours of constant minVAR, short for minimum variance, through extension to three coordinate dimensions. These contours capture point-by-point representations of thousands of individual atmospheric aerosol and/or cloud particles as they evolve and are rendered on Eulerian grids at a level of sub-grid resolution limited only by numerical precision; and (2) exploration of geometric similarities between the Arakawa C-grid, used to obtain interpolated values of the wind field at grid scale and minVAR. In particular, we consider interpolation of the u and v horizontal components of wind velocity from grid to sub-grid scales. The last results are motivated by recent applications of the Weather Research and Forecasting (WRF) model applied in the coastal Houston region, where the recent TRacking Aerosol Convection Interactions ExpeRiment (TRACER) field campaign was organized. A unique and fully consistent mapping is obtained between particles moving along meteorological wind trajectories and the non-diffusive, non-dispersive representation of such trajectories on an Eulerian grid. Full article
(This article belongs to the Special Issue Geometry in Meteorology and Climatology)
17 pages, 2794 KiB  
Article
Security Operations Centers: Use Case Best Practices, Coverage, and Gap Analysis Based on MITRE Adversarial Tactics, Techniques, and Common Knowledge
by Samir Achraf Chamkar, Yassine Maleh and Noreddine Gherabi
J. Cybersecur. Priv. 2024, 4(4), 777-793; https://doi.org/10.3390/jcp4040036 (registering DOI) - 25 Sep 2024
Abstract
The rising frequency and complexity of cybersecurity threats necessitate robust monitoring and rapid response capabilities to safeguard digital assets effectively. As a result, many organizations are increasingly establishing Security Operations Centers (SOCs) to actively detect and respond to cybersecurity incidents. This paper addresses [...] Read more.
The rising frequency and complexity of cybersecurity threats necessitate robust monitoring and rapid response capabilities to safeguard digital assets effectively. As a result, many organizations are increasingly establishing Security Operations Centers (SOCs) to actively detect and respond to cybersecurity incidents. This paper addresses the intricate process of setting up a SOC, emphasizing the need for careful planning, substantial resources, and a strategic approach. This study outlines the essential steps involved in defining the SOC’s objectives and scope, selecting appropriate technologies, recruiting skilled cybersecurity professionals, and developing processes throughout the SOC lifecycle. This paper aims to provide a comprehensive understanding of the SOC’s threat detection capabilities and use cases. It also highlights the importance of choosing technologies that integrate seamlessly with existing IT infrastructure to ensure broad coverage of SOC activities. Furthermore, this study offers actionable insights for organizations looking to enhance their SOC capabilities, including a technical overview of SOC use case coverage and a gap assessment of detection rules. This assessment is based on an alignment with the MITRE ATT&CK framework and an analysis of events generated by the company’s existing IT devices and products. The findings from this research elucidate the indispensable role that SOCs play in bolstering organizational cybersecurity and resilience. Full article
(This article belongs to the Special Issue Cybersecurity Risk Prediction, Assessment and Management)
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16 pages, 1031 KiB  
Article
Comprehensive Study on the Potential of Domesticated Clones of Rosemary (Salvia rosmarinus Spenn.): Implications for Large-Scale Production and Waste Recovery in the Development of Plant-Based Agrochemicals
by Gonzalo Ortiz de Elguea-Culebras, Enrique Melero-Bravo, Tamara Ferrando-Beneyto, María José Jordán, Gustavo Cáceres-Cevallos and Raúl Sánchez-Vioque
Agriculture 2024, 14(10), 1678; https://doi.org/10.3390/agriculture14101678 (registering DOI) - 25 Sep 2024
Abstract
Rosemary is a versatile Mediterranean shrub valued for its culinary and medicinal uses, also finding applications as a food additive (E-392). This study explores the potential of rosemary for large-scale cultivation as well as the valorization of its distillation residue, which constitutes more [...] Read more.
Rosemary is a versatile Mediterranean shrub valued for its culinary and medicinal uses, also finding applications as a food additive (E-392). This study explores the potential of rosemary for large-scale cultivation as well as the valorization of its distillation residue, which constitutes more than 95% of the total biomass. Rich in bioactive compounds, this solid waste represents a valuable opportunity to develop renewable plant-based products. This study monitored the agronomic adaptations of cultivated clones of rosemary and evaluated the essential oil and phenolic content. This study also evaluated the biological potential of the ethanolic extracts from the distilled residue as an antifungal, antioxidant, chelator, and biostimulant in model tests. Interestingly, the extracts showed substantial phenolic content, exhibiting strong antifungal activity, antioxidant capacity, and efficient metal chelation. Furthermore, all extracts also demonstrated promising biostimulant effects on rooting. Among the clones evaluated, Pina de Ebro stood out especially for its balanced adaptability, high essential oil yield, and outstanding phenolic content, along with uniform biological capacities among individual plants and plots. Therefore, this study highlights the potential of utilizing the entire rosemary plant, enhancing the overall profitability of the crop and meeting the growing demand for eco-friendly and renewable resources in the market. Full article
(This article belongs to the Section Crop Protection, Diseases, Pests and Weeds)
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14 pages, 1424 KiB  
Article
A New Combination of Bifidobacterium Bifidum and Lactococcus Lactis Strains with Synergistic Effects Alleviates Colitis-Associated Colorectal Cancer
by Jiacui Shang, Lijun Liu, Shuo Yang, Bofan Duan, Shuiqi Xie and Xiangchen Meng
Foods 2024, 13(19), 3054; https://doi.org/10.3390/foods13193054 (registering DOI) - 25 Sep 2024
Abstract
C hronic inflammation is a factor in the development of cancer, and probiotics play a role in preventing or treating inflammation as an adjuvant therapy. To investigate potential probiotics for the prevention of colitis-associated colorectal cancer (CAC), Bifidobacterium bifidum H3-R2 and Lactococcus lactis KLDS4.0325 [...] Read more.
C hronic inflammation is a factor in the development of cancer, and probiotics play a role in preventing or treating inflammation as an adjuvant therapy. To investigate potential probiotics for the prevention of colitis-associated colorectal cancer (CAC), Bifidobacterium bifidum H3-R2 and Lactococcus lactis KLDS4.0325 were used to examine the effects on colon cancer cells and in an inflammation-related cancer animal model. The results revealed that B. bifidum H3-R2 in combination with L. lactis KLDS4.0325 caused apoptosis in colon cancer cells by increasing caspase-3 and caspase-9 protein levels, enhancing Bax expression, and lowering Bcl-2 expression. In addition, the combination of the two strains relieved the tissue damage; reduced proinflammatory cytokines, myeloperoxidase (MPO) activity, and hypoxia-inducible factor 1-alpha (HIF-1α) level; upregulated anti-inflammatory cytokines; increased colonic tight junction protein expression; regulated intestinal homeostasis by inhibiting NLRP3 inflammasome signaling pathway; and improved the imbalance of gut microbiota in animal models. Moreover, the combination of the two strains had a greater preventive impact than each strain alone. These findings are supportive of clinical studies and product development of multi-strain probiotic preparations for diseases associated with colitis. Full article
(This article belongs to the Section Food Microbiology)
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14 pages, 1752 KiB  
Article
Pediatric Respiratory Hospitalizations in the Pre-COVID-19 Era: The Contribution of Viral Pathogens and Comorbidities to Clinical Outcomes, Valencia, Spain
by Valérie Bosch Castells, Ainara Mira-Iglesias, Francisco Xavier López-Labrador, Beatriz Mengual-Chuliá, Mario Carballido-Fernández, Miguel Tortajada-Girbés, Joan Mollar-Maseres, Joan Puig-Barberà, Javier Díez-Domingo and Sandra S. Chaves
Viruses 2024, 16(10), 1519; https://doi.org/10.3390/v16101519 (registering DOI) - 25 Sep 2024
Abstract
Viral respiratory diseases place a heavy burden on the healthcare system, with children making up a significant portion of related hospitalizations. While comorbidities increase the risk of complications and poor outcomes, many hospitalized children lack clear risk factors. As new vaccines for respiratory [...] Read more.
Viral respiratory diseases place a heavy burden on the healthcare system, with children making up a significant portion of related hospitalizations. While comorbidities increase the risk of complications and poor outcomes, many hospitalized children lack clear risk factors. As new vaccines for respiratory viral diseases emerge, this study examined pediatric respiratory hospitalizations, focusing on viral etiology, complication rates, and the impact of comorbidities to guide future policy. Data were analyzed from eight pre-COVID influenza seasons (2011/2012–2018/2019) involving patients under 18 years hospitalized with respiratory complaints across 4–10 hospitals in Valencia, Spain. Respiratory specimens were tested for eight viral targets using multiplex real-time reverse-transcription polymerase chain reaction. Demographics, clinical outcomes, discharge diagnoses, and laboratory results were examined. Among the hospitalized children, 26% had at least one comorbidity. These children had higher rates of pneumonia, asthma exacerbation, and pneumothorax, and were twice as likely to require ICU admission, though mechanical ventilation and length of stay were similar to those without comorbidities. Respiratory syncytial virus (RSV) was the most common virus detected (23.1%), followed by rhinovirus/enterovirus (9.5%) and influenza (7.2%). Viral codetection decreased with age, occurring in 4.6% of cases. Comorbidities increase the risk of complications in pediatric respiratory illnesses, however, healthcare utilization is driven largely by otherwise healthy children. Pediatric viral vaccines could reduce this burden and should be further evaluated. Full article
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18 pages, 1016 KiB  
Article
Evaluation of the Bioactive Compounds of Apis mellifera Honey Obtained from the Açai (Euterpe oleracea) Floral Nectar
by Sara R. L. Ferreira, Jéssica L. Araújo, Marly S. Franco, Camilla M. M. de Souza, Daniel S. Pereira, Cláudia Q. da Rocha, Hervé L. G. Rogez and Nilton A. Muto
Molecules 2024, 29(19), 4567; https://doi.org/10.3390/molecules29194567 (registering DOI) - 25 Sep 2024
Abstract
The biodiversity of Brazil provides an excellent climate and favorable pollination conditions for Apis mellifera L., especially in the Eastern Amazon region, which boasts vast floral wealth, including an abundance of açaí (Euterpe oleracea) flowers and fruits. In the present study, [...] Read more.
The biodiversity of Brazil provides an excellent climate and favorable pollination conditions for Apis mellifera L., especially in the Eastern Amazon region, which boasts vast floral wealth, including an abundance of açaí (Euterpe oleracea) flowers and fruits. In the present study, seven types of honey were evaluated: three containing floral nectar from açaí (Açaí honey) collected in the Eastern Amazon region (Açaí honey from Breu Branco (AH1 and AH2) and Açaí honey from Santa Maria (AH3), both from the state of Pará, Brazil) and four honeys from different regions of Brazil (Aroeira honey from Minas Gerais, Cipó-Uva honey from Distrito Federal, Mangue honey from Pará, and Timbó honey from Rio Grande do Sul). The characteristics of these honeys were evaluated by examining their physicochemical properties, melissopalynological aspects, color, antioxidant potential, and their constituent compounds, which were confirmed through GC-MS analysis. Açaí floral nectar honeys presented physicochemical results similar to those of other honeys, aligning with Brazilian legislation norms, but differed in their high values of free acidity, apparent sugars, and lower reducing sugars, which are directly related to their botanical origin. These differences correlate with unique flavor and distinct aroma characteristics. Melissopalynological analysis confirmed the botanical origin of the honeys containing açaí floral nectar, which had a color range from amber to dark amber. The three açaí honeys demonstrated high antioxidant capacity and superior flavonoid and polyphenol content compared to other honeys, particularly the açaí honey from Breu Branco (AH1), which had four times the content to combat free radicals compared to the honey with the highest potential (Aroeira honey). GC-MS analysis confirmed the presence of antioxidant properties as well as potential anti-inflammatory, antibacterial, antimicrobial, and antitumor capabilities in açaí honeys, which have not yet been fully studied. Full article
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