Search Results (1,469,506)

As in any other industry, nuclear energy results in the accumulation of some waste, which needs to be managed safely and responsibly due to its radiotoxicity. In the case of highly radioactive waste, geological disposal in stable rock is considered a broadly accepted solution. For the evaluation of the long-term safety of a geological repository, the assessment of radionuclide transport needs to be carried out. Radionuclide transport through engineered and natural barriers of the repository will highly depend on the barriers’ transport-related properties, which will be determined by coupled thermal, hydraulic, chemical, mechanical, biological, and radiation processes taking place in those barriers. In this study, the thermo-hydro-chemical (THC) state of bentonite was analysed considering CO₂ gas diffusion and temperature-dependent solubility in water. Reactive transport modelling of bentonite under non-isothermal conditions was performed with the COMSOL Multiphysics software (v6.0), coupled with the geochemical solver Phreeqc via the iCP interface. The modelling demonstrated that the consideration of chemical processes in bentonite had no significant influence on non-reactive Cl⁻ transport; however, it would be important for other radionuclides whose sorption in porous media depends on the porewater pH. Based on the modelling results, changes in the bentonite mineralogical composition and, subsequently, porosity depend on the partial CO₂ pressure at the bentonite–granite boundary. In the case of low CO₂ partial pressure at the bentonite–granite interface, the calcite dissolution led to a slight porosity increase, while higher CO₂ partial pressure led to decreased porosity near the interface. Full article

Traditional myoelectric controls of trans-humeral prostheses fail to provide intuitive coordination of the necessary degrees of freedom. We previously showed that by using artificial neural network predictions to reconstruct distal joints, based on the shoulder posture and movement goals (i.e., position and orientation of the targeted object), participants were able to position and orient an avatar hand to grasp objects with natural arm performances. However, this control involved rapid and unintended prosthesis movements at each modification of the movement goal, impractical for real-life scenarios. Here, we eliminate this abrupt change using novel methods based on an angular trajectory, determined from the speed of stump movement and the gap between the current and the ‘goal’ distal configurations. These new controls are tested offline and online (i.e., involving participants-in-the-loop) and compared to performances obtained with a natural control. Despite a slight increase in movement time, the new controls allowed twelve valid participants and six participants with trans-humeral limb loss to reach objects at various positions and orientations without prior training. Furthermore, no usability or workload degradation was perceived by participants with upper limb disabilities. The good performances achieved highlight the potential acceptability and effectiveness of those controls for our target population. Full article

This article examines the impact of meteorological conditions represented by ambient temperature, ambient humidity, wind speed, and daily precipitation sum on the reliability of low-voltage cable lines. Cable line reliability is crucial to the stability and safety of power systems. Failure of cable lines can lead to power outages. This can cause serious economic and social consequences, as well as threaten human safety, especially in the public sector and critical infrastructure. In addition, any interruption of cable lines generates costs related to repairs, operational losses, and possible contractual penalties. This is why it is so important to investigate the causes of power equipment failures. Many power system failures are caused by weather factors. The main purpose of this article is to quantify the actual impact of weather conditions on the performance and reliability of power equipment in distribution networks. Reliability indicators (failure rate, failure duration, restoration rate, and failure coefficient) for low-voltage cable lines were calculated as a function of weather conditions. Empirical values of the indicators were determined based on many years of observations of power lines operating in the Polish power system. An analysis of the conformity of their empirical distribution with the assumed theoretical model was also conducted. By quantifying the impact of specific weather factors on the operation of power equipment, it becomes possible to identify the ranges in which failures are most likely. Full article

Developing short-term forecasting models for global atmospheric temperature and wind in near space is crucial for understanding atmospheric dynamics and supporting human activities in this region. While numerical models have been extensively developed, deep learning techniques have recently shown promise in improving atmospheric forecasting accuracy. In this study, convolutional long short-term memory (ConvLSTM) and convolutional gated recurrent unit (ConvGRU) neural networks were applied to build for short-term global-scale forecasting model of atmospheric temperature and wind in near space based on the MERRA-2 reanalysis dataset from 2010–2022. The model results showed that the ConvGRU model outperforms the ConvLSTM model in the short-term forecast results. The ConvGRU model achieved a root mean square error in the first three hours of approximately 1.8 K for temperature predictions, and errors of 4.2 m/s and 3.8 m/s for eastward and northward wind predictions on all 72 isobaric surfaces. Specifically, at a higher altitude (on the 1.65 Pa isobaric surface, approximately 70 km above sea level), the ConvGRU model achieved a RMSE of about 2.85 K for temperature predictions, and 5.67 m/s and 5.17 m/s for eastward and northward wind. This finding is significantly meaningful for short-term temperature and wind forecasts in near space and for exploring the physical mechanisms related to temperature and wind variations in this region. Full article

Repurposing saffron (Crocus sativus) waste presents a sustainable strategy for generating high-value products within the bioeconomy framework. Typically, flower components are discarded after stigma harvest, resulting in significant waste—350 kg of tepals per kilogram of stigmas. This research employed a comprehensive approach, integrating bioactivity studies (in vitro and in silico) with Life Cycle Assessment (LCA) evaluations, to extract and assess bioactive compounds from C. sativus tepals sourced in Tuscany, Italy. Phytochemical characterization using UPLC-MS/MS revealed a high abundance and variety of flavonoids in the hydro-ethanolic extract (CST). The antioxidant capacity was validated through various assays, and the ability to mitigate H₂O₂-induced oxidative stress and enhance fermentation was demonstrated in Saccharomyces cerevisiae. This study reports that C. sativus tepals extract reduces oxidative stress and boosts ethanol fermentation in yeast, paving the way for applications in the food and biofuels sectors. Further validation in RAW 264.7 macrophages confirmed CST’s significant anti-inflammatory effects, indicating its potential for pharmaceutical, cosmeceutical, and nutraceutical applications. In silico studies identified potential targets involved in antioxidant and anti-inflammatory processes, shedding light on possible interaction mechanisms with Kaempferol 3-O-sophoroside (KOS-3), the predominant compound in the extract. The integration of LCA studies highlighted the environmental benefits of this approach. Overall, this research underscores the value of using waste-derived extracts through “green” methodologies, offering a model that may provide significant advantages for further evaluations compared to traditional methodologies and supporting the circular bioeconomy. Full article

In this paper, we introduce the concept of generalized Fourier series, generated by the p-trigonometric functions, namely cosp and sinp, recently introduced related to the generalized complex numbers systems. The aim of this study is to represent a periodic signal as a sum of p-sine and p-cosine functions. In order to achieve this, we first present the integrals of the product of the same or different family of p-trigonometric functions over the full period of these functions to understand the orthogonality properties. Next, we use these integrals to derive the coefficients of the generalized p-Fourier series along with a few examples. The generalized Fourier series can be used to expand an arbitrary forcing function in the solution of a non-homogeneous linear ordinary differential equation (ODE) with constant coefficients. Full article

The silverleaf whitefly, Bemisia tabaci Gennadius (Hemiptera: Aleyrodidae), is a significant agricultural pest worldwide, impacting a variety of crop yields. Since the introduction of B. tabaci Mediterranean (MED) species in Brazil, limited research has measured the relative efficacy of the primary insecticides used in whitefly management. This study evaluated the susceptibility of three distinct B. tabaci MED populations to 11 insecticide active ingredients and characterized the bacterial endosymbionts within each population. The insecticides tested were acetamiprid, bifenthrin, cyantraniliprole, diafenthiuron, spiromesifen, imidacloprid, pymetrozine, pyriproxyfen, sulfoxaflor, and thiamethoxam. Results showed varying LC₅₀ and LC₉₀ values among tested insecticides and populations. Notably, populations varied in response to imidacloprid and thiamethoxam with some populations having a 6× higher tolerance. Sequencing data of endosymbionts revealed that individuals from the most susceptible B. tabaci population harbored Rickettsia and Arsenophonus, whereas these bacteria were not detected in the resistant populations. These findings highlight the need for frequent insecticide toxicity bioassays of distinct B. tabaci populations and the adoption of integrated pest management strategies to preserve the efficacy of insecticides for B. tabaci control. Additionally, the role of infection by endosymbionts to alter susceptibility should be further explored. Full article

The swap-body vehicle routing problem (SBVRP) represents a specialized extension of the traditional vehicle routing problem (VRP), incorporating additional practical complexities. Effective fuel consumption management and the scheduling of multiple vehicle trips are pivotal strategies for reducing costs and ensuring the sustainability of distribution systems. In response to the acceleration of urbanization, the rising demand for logistics, and the deteriorating living environment, we introduce an SBVRP considering fuel consumption and multiple trips to enable greener, cheaper, and more efficient delivery methods. To tackle the SBVRP, we propose a hybrid multi-population genetic algorithm enhanced with local search techniques to explore various areas of the search space. Computational experiments demonstrate the efficiency of the proposed method and the effectiveness of its components. The algorithm developed in this study provides an optimized solution to the VRP, focusing on achieving environmentally friendly, sustainable, and cost-effective transportation by reducing energy consumption and promoting the rational use of resources. Full article

Activating FLT3 mutations plays a crucial role in leukemogenesis, but identifying the optimal candidates for FLT3 inhibitor therapy remains controversial. This study aims to explore the impacts of FLT3 mutations in pediatric acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) and to compare the mutation profiles between the two types to inspire the targeted application of FLT3 inhibitors. We retrospectively analyzed 243 ALL and 62 AML cases, grouping them into FLT3-mutant and wild-type categories, respectively. We then assessed the associations between FLT3 mutations and the clinical manifestations, genetic characteristics, and prognosis in ALL and AML. Additionally, we compared the distinct features of FLT3 mutations between ALL and AML. In ALL patients, those with FLT3 mutations predominantly exhibited hyperdiploidy (48.6% vs. 14.9%, p < 0.001) and higher FLT3 expression (108.02 [85.11, 142.06] FPKM vs. 23.11 [9.16, 59.14] FPKM, p < 0.001), but lower expression of signaling pathway-related genes such as HRAS, PIK3R3, BAD, MAP2K2, MAPK3, and STAT5A compared to FLT3 wild-type patients. There was no significant difference in prognosis between the two groups. In contrast, AML patients with FLT3 mutations were primarily associated with leucocytosis (82.90 [47.05, 189.76] G/L vs. 20.36 [8.90, 55.39] G/L, p = 0.001), NUP98 rearrangements (30% vs. 4.8%, p = 0.018), elevated FLT3 expression (74.77 [54.31, 109.46] FPKM vs. 34.56 [20.98, 48.28] FPKM, p < 0.001), and upregulated signaling pathway genes including PIK3CB, AKT1, MTOR, BRAF, and MAPK1 relative to FLT3 wild-type, correlating with poor prognosis. Notably, internal tandem duplications were the predominant type of FLT3 mutation in AML (66.7%) with higher inserted base counts, whereas they were almost absent in ALL (6.3%, p < 0.001). In summary, our study demonstrated that the forms and impacts of FLT3 mutations in ALL differed significantly from those in AML. The gene expression profiles of FLT3-related pathways may provide a rationale for using FLT3 inhibitors in AML rather than ALL when FLT3 mutations are present. Full article

Taurolidine, known for its broad-spectrum antimicrobial properties and low toxicity, has shown promise in reducing infections in various surgical settings. However, it has not been extensively evaluated in orthopedic surgery. This study assessed the efficacy of taurolidine irrigation in reducing surgical site infections in patients undergoing ankle fracture surgery. A retrospective review was conducted for patients >20 years old who underwent ankle fracture surgery between March 2016 and March 2023, with follow-ups exceeding 6 months. Patients were classified into the following two groups: those who underwent normal saline (NS) irrigation and those who underwent taurolidine irrigation. Minor infections were defined as requiring additional oral antibiotics postoperatively, while major infections were characterized by hospitalization or reoperation due to infection within 3 months. Of 844 patients, 688 were included. The taurolidine group (n = 328) had a significant reduction in minor infections (7.3% vs. 22.5%, odds ratio = 0.410, p = 0.028) compared to the NS group (n = 360). Major infections were fewer in the NS group (1.2% vs. 0%, p = 0.051), but the number of cases was too small for reliable analysis. Taurolidine irrigation significantly reduces the occurrence of minor infections in ankle fracture surgeries when compared to normal saline irrigation. Full article

Improving the performance at signalized intersections can be achieved through different management styles or sensor technologies. It is crucial that we measure the real-time impact of these variables on intersection performance. This study introduces a Bluetooth-based real-time performance measurement system applicable to all signalized intersections. Additionally, the developed method serves as a feedback tool for adaptive intersection management systems, providing valuable data input for performance optimization. The method developed in the study is applied at the Refik Cesur Intersection in the Polatlı district of Ankara where delay values are calculated based on traffic flows and data from Bluetooth sensors positioned at strategic locations. Initially, the intersection operated under a fixed-time signaling system, followed by a fully adaptive signaling system the next day. The performance of these two systems is compared using the Bluetooth-based application. The results show that the average delay per vehicle per day is 58.1 seconds/vehicle for the fixed-time system and 45.3 seconds/vehicle for the adaptive system. To validate the Bluetooth-based performance measurement system, the intersection is modeled and simulated using Aimsun Simulation Software Next 20.0.4. The simulation results confirm the findings of the Bluetooth-based analysis, demonstrating the effectiveness of the adaptive signaling system in reducing delays. Full article

To enhance the stability of photovoltaic power grid integration and improve power prediction accuracy, a photovoltaic power prediction method based on an improved snow ablation optimization algorithm (Good Point and Vibration Snow Ablation Optimizer, GVSAO) and Bi-directional Long Short-Term Memory (Bi-LSTM) network is proposed. Weather data is divided into three typical categories using K-means clustering, and data normalization is performed using the minmax method. The key structural parameters of Bi-LSTM, such as the feature dimension at each time step and the number of hidden units in each LSTM layer, are optimized based on the Good Point and Vibration strategy. A prediction model is constructed based on GVSAO-Bi-LSTM, and typical test functions are selected to analyze and evaluate the improved model. The research results show that the average absolute percentage error of the GVSAO-Bi-LSTM prediction model under sunny, cloudy, and rainy weather conditions are 4.75%, 5.41%, and 14.37%, respectively. Compared with other methods, the prediction results of this model are more accurate, verifying its effectiveness. Full article

Decarbonizing the mobility and heating sector involves increasing connected components in low-voltage grids. The simulation of distribution grids and the incorporation of an energy system are relevant instruments for evaluating the effects of these developments. However, grids are highly diversified, and with over 900,000 low-voltage grids in Germany, the simulation would require significant data management and computing capacity. A solution already applied in the literature is the simulation of representative grids. Here, we show the compatibility of clusters and representatives for grid topologies from the literature and further extend and validate them by applying accurate grid data. Our analysis indicates that clusters from the literature unify well across three key parameters but also reveals that the clusters still exclude a relevant amount of grids. Extension, reclassification, and validation using about 1200 real grids establish meta-clusters covering the spectrum of grids from rural to urban regions, focusing on residential to commercial supply tasks. We anticipate our assay to be a further relevant step toward typifying low-voltage distribution grids in Germany. Full article

Bone tissue regeneration is a critical aspect of dental surgery, given the common occurrence of bone resorption leading to alveolar bone defects. The aim of this paper was to conduct a systematic review to provide a comprehensive summary of the evidence regarding the regenerative properties of dentin biomaterial. This systematic review was conducted through comprehensive searches in the PubMed, Scopus, and Web of Science databases, as well as an extensive exploration of the gray literature sources, including WorldCat, The New York Academy of Medicine Library, and Trip Database, following the established PRISMA protocol. Keywords such as tooth, dentin, grinder, and autograft guided the search, with a focus on a standardized procedure involving dentin grinders within laboratory, experimental, and clinical settings. Initially, a pool of 1942 articles was identified with 452 duplicates removed. An additional 1474 articles were excluded for not aligning with the predefined topics, and three more were excluded due to the unavailability of the full text. Ultimately, 13 articles met the strict inclusion criteria and were included in the review. The chemical composition of the dentin particles was similar to natural bone in terms of oxygen, carbon, calcium, phosphorus, sodium, and magnesium content, as well as in terms of the Ca/P ratio. In addition, the dentin also contained amide I and amide II structures, as well as aliphatic and hydroxyl functional groups. The chemically treated dentin was free of microorganisms. The dentin had characteristic tubules that opened after chemical treatment. At the cellular level, dentin released bone morphogenetic protein 2, induced significant cell growth, and stimulated the reorganization of the fibroblast cytoskeleton. Most clinical studies have focused on alveolar bone regeneration. After the transplantation of demineralized dentin particles, studies have observed new bone formation, a reduction in residual bone, and an increase in connective tissue. Clinical reports consistently indicate uncomplicated healing and recovery post-transplantation. However, there is a notable gap in the evidence concerning complication rates, patient-reported outcomes, and the presence of pro-inflammatory factors. In conclusion, dentin biomaterial emerges as a versatile bone substitute, demonstrating high biocompatibility and ease of acquisition. The preservation of its internal structure containing organic matter and growth factors enhances its potential for effective bone regeneration. Particularly, in dental surgery, dentin-derived materials present a promising alternative to traditional autologous bone autografts, offering the potential to reduce patient morbidity and treatment costs. Full article

Although many physical activity (PA) interventions for older adults have proven effective in controlled research settings, optimal implementation in real life remains challenging. This study identifies determinants perceived by stakeholders when implementing community-based PA interventions for older adults. We interviewed 31 stakeholders guided by the Consolidated Framework for Implementation Research (CFIR). Results showed that stakeholders are very specific about the role they can play in implementation, making collaboration between stakeholders crucial. Barriers and motivators were identified in the CFIR intervention characteristics domain (relative advantage, complexity and costs, evidence quality and strength, and adaptability and trialability), in the outer setting domain (cosmopolitism, patient needs, and external policy and incentives), in the inner setting domain (implementation climate, relative priority, compatibility and organizational incentives and rewards) and in the individual characteristics domain (knowledge and beliefs, and other personal attributes). An overarching theme was the stakeholders’ emphasis on aiming for broad health goals in interventions, as they perceive PA as a means to reach these goals rather than an end in itself. Another overarching theme requiring attention in future implementation efforts is the need to tailor implementation efforts to the specific needs of older adults as the end users of the intervention. Full article