Alteration of the timing of implantation by in vivo gene transfer: delay of implantation by suppression of nuclear factor kappaB activity and partial rescue by leukemia inhibitory factor.

Nakamura H; Kimura T; Ogita K; Koyama S; Tsujie T; Tsutsui T; Shimoya K; Koyama M; Kaneda Y; Murata Y

doi:10.1016/j.bbrc.2004.07.045

Alteration of the timing of implantation by in vivo gene transfer: delay of implantation by suppression of nuclear factor kappaB activity and partial rescue by leukemia inhibitory factor.

Affiliations

1. Division of Obstetrics and Gynecology, Department of Specific Organ Regulation, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 5650871, Japan.
Authors
Nakamura H¹
(1 author)

Biochemical and Biophysical Research Communications, 01 Sep 2004, 321(4):886-892
https://doi.org/10.1016/j.bbrc.2004.07.045 PMID: 15358109

Abstract

Nuclear factor kappaB (NF-kappaB) is activated in the murine endometrium during implantation period [Am. J. Reprod. Immunol. 51 (2004) 16]. Transient transfection of IkappaBalpha mutant (IkappaBalphaM) cDNA into the mouse uterine cavity using hemagglutinating virus of Japan envelope vector suppressed uterine NF-kappaB activity less than half of that observed in control on days 3.5 and 4.5 p.c. IkappaBalphaM cDNA transfection led to significant delay of implantation. After IkappaBalphaM cDNA transfection, LIF mRNA expression in the uterus was significantly suppressed on days 3.5 and 4.5 p.c. Co-transfection of LIF cDNA with IkappaBalphaM cDNA in the uterus partially rescued the delay of implantation induced by suppression of NF-kappaB activity. Taken together, these findings indicate that NF-kappaB activation determines the timing of the implantation, at least in part, via control of LIF expression.

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References

Articles referenced by this article (32)

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Funding

Funders who supported this work.

Japan Society for the Promotion of Science (4)

Grant ID: 16390476
3 publications
Grant ID: 15591746
2 publications
Grant ID: 14571557
3 publications
Grant ID: 15390505
2 publications

Search life-sciences literature (44,810,749 articles, preprints and more)

Alteration of the timing of implantation by in vivo gene transfer: delay of implantation by suppression of nuclear factor kappaB activity and partial rescue by leukemia inhibitory factor.

Affiliations

Authors

Abstract

Full text links

References

NF-kappaB activation at implantation window of the mouse uterus.

Implantation: molecular basis of embryo-uterine dialogue.

Inhibition of implantation by advancement of uterine sensitivity and refractoriness

Potential biochemical markers of uterine receptivity.

Activation of kappa B-specific proteins by estradiol.

Expression of nuclear factor kappa B components in human endometrium.

Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses.

Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel family.

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B.

Complete lack of NF-kappaB activity in IKK1 and IKK2 double-deficient mice: additional defect in neurulation.

Citations & impact

Impact metrics

Citations of article over time

Smart citations by scite.ai
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1016/j.bbrc.2004.07.045

Article citations

Endometrial Inflammation and Impaired Spontaneous Decidualization: Insights into the Pathogenesis of Adenomyosis.

An In Vivo Screening Model for Investigation of Pathophysiology of Human Implantation Failure.

Gene Therapy for Malignant and Benign Gynaecological Disorders: A Systematic Review of an Emerging Success Story.

TOP2A deficit-induced abnormal decidualization leads to recurrent implantation failure via the NF-κB signaling pathway.

The Targeting of Nuclear Factor Kappa B by Drugs Adopted for the Prevention and Treatment of Preeclampsia.

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Funding

Japan Society for the Promotion of Science (4)

Ministry of Education, Culture, Sports, Science and Technology

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Search life-sciences literature (44,810,749 articles, preprints and more)

Alteration of the timing of implantation by in vivo gene transfer: delay of implantation by suppression of nuclear factor kappaB activity and partial rescue by leukemia inhibitory factor.

Author information

Affiliations

Authors

Abstract

Full text links

References

Inhibition of implantation by advancement of uterine sensitivity and refractoriness

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Funding

Japan Society for the Promotion of Science (4)﻿

Ministry of Education, Culture, Sports, Science and Technology

Partnerships & funding

Japan Society for the Promotion of Science (4)