Overview of Pectin-Derived Microparticles through Microfluidic Technology
Abstract
:1. Introduction
2. Fundamentals of Microfluidic Technology
3. Polymeric Microparticles
4. The Case of Pectin
5. Pectin-Derived Microparticles
6. Applications of Pectin in Microparticle Production via Microfluidics
7. Conclusions
Author Contributions
Funding
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
- Pei, Y.; Wang, J.; Khaliq, N.U.; Meng, F.; Oucherif, K.A.; Xue, J.; Horava, S.D.; Cox, A.L.; Richard, C.A.; Swinney, M.R.; et al. Development of Poly(Lactide-Co-Glycolide) Microparticles for Sustained Delivery of Meloxicam. J. Control. Release 2023, 353, 823–831. [Google Scholar] [CrossRef]
- Birk, S.E.; Boisen, A.; Nielsen, L.H. Polymeric Nano- and Microparticulate Drug Delivery Systems for Treatment of Biofilms. Adv. Drug Deliv. Rev. 2021, 174, 30–52. [Google Scholar] [CrossRef]
- Lee, S.; Koo, J.; Kang, S.-K.; Park, G.; Lee, Y.J.; Chen, Y.-Y.; Lim, S.A.; Lee, K.-M.; Rogers, J.A. Metal Microparticle—Polymer Composites as Printable, Bio/Ecoresorbable Conductive Inks. Mater. Today 2018, 21, 207–215. [Google Scholar] [CrossRef]
- Scholtz, L. Correlating Semiconductor Nanoparticle Architecture and Applicability for the Controlled Encoding of Luminescent Polymer Microparticles. Sci. Rep. 2024, 14, 11904. [Google Scholar] [CrossRef]
- Peñalva, R.; Martínez-López, A.L.; Gamazo, C.; Gonzalez-Navarro, C.J.; González-Ferrero, C.; Virto-Resano, R.; Brotons-Canto, A.; Vitas, A.I.; Collantes, M.; Peñuelas, I.; et al. Encapsulation of Lactobacillus Plantarum in Casein-Chitosan Microparticles Facilitates the Arrival to the Colon and Develops an Immunomodulatory Effect. Food Hydrocoll. 2023, 136, 108213. [Google Scholar] [CrossRef]
- Günter, E.A.; Melekhin, A.K.; Belozerov, V.S.; Martinson, E.A.; Litvinets, S.G. Preparation, Physicochemical Characterization and Swelling Properties of Composite Hydrogel Microparticles Based on Gelatin and Pectins with Different Structure. Int. J. Biol. Macromol. 2024, 258, 128935. [Google Scholar] [CrossRef]
- Dong, Z.; Xu, H.; Bai, Z.; Wang, H.; Zhang, L.; Luo, X.; Tang, Z.; Luque, R.; Xuan, J. Microfluidic Synthesis of High-Performance Monodispersed Chitosan Microparticles for Methyl Orange Adsorption. RSC Adv. 2015, 5, 78352–78360. [Google Scholar] [CrossRef]
- Caruso, M.R.; D’Agostino, G.; Wasserbauer, J.; Šiler, P.; Cavallaro, G.; Milioto, S.; Lazzara, G. Filling of Chitosan Film with Wax/Halloysite Microparticles for Absorption of Hydrocarbon Vapors. Adv. Sustain. Syst. 2024, 8, 2400026. [Google Scholar] [CrossRef]
- Polat, H.K.; Aytekin, E.; Karakuyu, N.F.; Çaylı, Y.A.; Çalamak, S.; Demirci, N.; Ünal, S.; Kurt, N.; Çırak, R.; Erkan, E.; et al. Harnessing Silk Fibroin Microparticles for Metformin Delivery: A Novel Approach to Treating Corneal Neovascularization. J. Drug Deliv. Sci. Technol. 2024, 96, 105625. [Google Scholar] [CrossRef]
- Shim, H.-E.; Kim, Y.-J.; Park, K.H.; Park, H.; Huh, K.M.; Kang, S.-W. Enhancing Cartilage Regeneration through Spheroid Culture and Hyaluronic Acid Microparticles: A Promising Approach for Tissue Engineering. Carbohydr. Polym. 2024, 328, 121734. [Google Scholar] [CrossRef]
- Zheng, C.; Teng, C.P.; Yang, D.-P.; Lin, M.; Win, K.Y.; Li, Z.; Ye, E. Fabrication of Luminescent TiO2:Eu3+ and ZrO2:Tb3+ Encapsulated PLGA Microparticles for Bioimaging Application with Enhanced Biocompatibility. Mater. Sci. Eng. C 2018, 92, 1117–1123. [Google Scholar] [CrossRef]
- Galogahi, F.M.; Zhu, Y.; An, H.; Nguyen, N.-T. Core-Shell Microparticles: Generation Approaches and Applications. J. Sci. Adv. Mater. Devices 2020, 5, 417–435. [Google Scholar] [CrossRef]
- Khanthaphixay, B.; Wu, L.; Yoon, J.-Y. Microparticle-Based Detection of Viruses. Biosensors 2023, 13, 820. [Google Scholar] [CrossRef]
- Jo, Y.K.; Lee, D. Biopolymer Microparticles Prepared by Microfluidics for Biomedical Applications. Small 2020, 16, 1903736. [Google Scholar] [CrossRef]
- Zhang, X.; Qu, Q.; Zhou, A.; Wang, Y.; Zhang, J.; Xiong, R.; Lenders, V.; Manshian, B.B.; Hua, D.; Soenen, S.J.; et al. Core-Shell Microparticles: From Rational Engineering to Diverse Applications. Adv. Colloid Interface Sci. 2022, 299, 102568. [Google Scholar] [CrossRef]
- Galogahi, F.M.; Ansari, A.; Teo, A.J.T.; Cha, H.; An, H.; Nguyen, N.-T. Fabrication and Characterization of Core–Shell Microparticles Containing an Aqueous Core. Biomed. Microdevices 2022, 24, 40. [Google Scholar] [CrossRef]
- Li, W.; Zhang, L.; Ge, X.; Xu, B.; Zhang, W.; Qu, L.; Choi, C.-H.; Xu, J.; Zhang, A.; Lee, H.; et al. Microfluidic Fabrication of Microparticles for Biomedical Applications. Chem. Soc. Rev. 2018, 47, 5646–5683. [Google Scholar] [CrossRef]
- Zhang, Q.; Kuang, G.; Wang, L.; Fan, L.; Zhao, Y. Tailoring Drug Delivery Systems by Microfluidics for Tumor Therapy. Mater. Today 2024, 73, 151–178. [Google Scholar] [CrossRef]
- Shang, L.; Cheng, Y.; Zhao, Y. Emerging Droplet Microfluidics. Chem. Rev. 2017, 117, 7964–8040. [Google Scholar] [CrossRef]
- Sackmann, E.K.; Fulton, A.L.; Beebe, D.J. The Present and Future Role of Microfluidics in Biomedical Research. Nature 2014, 507, 181–189. [Google Scholar] [CrossRef]
- Elvira, K.S.; i Solvas, X.C.; Wootton, R.C.R.; deMello, A.J. The Past, Present and Potential for Microfluidic Reactor Technology in Chemical Synthesis. Nature Chem. 2013, 5, 905–915. [Google Scholar] [CrossRef]
- Sattari, A.; Hanafizadeh, P.; Hoorfar, M. Multiphase Flow in Microfluidics: From Droplets and Bubbles to the Encapsulated Structures. Adv. Colloid Interface Sci. 2020, 282, 102208. [Google Scholar] [CrossRef]
- Gimondi, S.; Ferreira, H.; Reis, R.L.; Neves, N.M. Microfluidic Devices: A Tool for Nanoparticle Synthesis and Performance Evaluation. ACS Nano 2023, 17, 14205–14228. [Google Scholar] [CrossRef]
- Moreira, A.; Carneiro, J.; Campos, J.B.L.M.; Miranda, J.M. Production of Hydrogel Microparticles in Microfluidic Devices: A Review. Microfluid. Nanofluid 2021, 25, 10. [Google Scholar] [CrossRef]
- Khotimchenko, M. Pectin Polymers for Colon-Targeted Antitumor Drug Delivery. Int. J. Biol. Macromol. 2020, 158, 1110–1124. [Google Scholar] [CrossRef]
- Cui, J.; Zhao, C.; Feng, L.; Han, Y.; Du, H.; Xiao, H.; Zheng, J. Pectins from Fruits: Relationships between Extraction Methods, Structural Characteristics, and Functional Properties. Trends Food Sci. Technol. 2021, 110, 39–54. [Google Scholar] [CrossRef]
- Sun, R.; Niu, Y.; Li, M.; Liu, Y.; Wang, K.; Gao, Z.; Wang, Z.; Yue, T.; Yuan, Y. Emerging Trends in Pectin Functional Processing and Its Fortification for Synbiotics: A Review. Trends Food Sci. Technol. 2023, 134, 80–97. [Google Scholar] [CrossRef]
- Whitesides, G.M. The Origins and the Future of Microfluidics. Nature 2006, 442, 368–373. [Google Scholar] [CrossRef]
- Fuciños, C.; Rodríguez-Sanz, A.; García-Caamaño, E.; Gerbino, E.; Torrado, A.; Gómez-Zavaglia, A.; Rúa, M.L. Microfluidics Potential for Developing Food-Grade Microstructures through Emulsification Processes and Their Application. Food Res. Int. 2023, 172, 113086. [Google Scholar] [CrossRef] [PubMed]
- Beebe, D.J.; Mensing, G.A.; Walker, G.M. Physics and Applications of Microfluidics in Biology. Annu. Rev. Biomed. Eng. 2002, 4, 261–286. [Google Scholar] [CrossRef] [PubMed]
- Liu, Z.; Fontana, F.; Python, A.; Hirvonen, J.T.; Santos, H.A. Microfluidics for Production of Particles: Mechanism, Methodology, and Applications. Small 2020, 16, 1904673. [Google Scholar] [CrossRef] [PubMed]
- MacClements, D.J.; McClements, D.J. Food Emulsions: Principles, Practices, and Techniques, 2nd ed.; CRC Series in Contemporary Food Science; CRC Press: Boca Raton, FL, USA, 2005; ISBN 978-0-8493-2023-1. [Google Scholar]
- Lu, Y.; Zhang, Y.; Zhang, R.; Gao, Y.; Miao, S.; Mao, L. Different Interfaces for Stabilizing Liquid–Liquid, Liquid–Gel and Gel–Gel Emulsions: Design, Comparison, and Challenges. Food Res. Int. 2024, 187, 114435. [Google Scholar] [CrossRef]
- Shah, R.K.; Shum, H.C.; Rowat, A.C.; Lee, D.; Agresti, J.J.; Utada, A.S.; Chu, L.-Y.; Kim, J.-W.; Fernandez-Nieves, A.; Martinez, C.J.; et al. Designer Emulsions Using Microfluidics. Mater. Today 2008, 11, 18–27. [Google Scholar] [CrossRef]
- Zhu, P.; Wang, L. Passive and Active Droplet Generation with Microfluidics: A Review. Lab Chip 2017, 17, 34–75. [Google Scholar] [CrossRef] [PubMed]
- Chong, Z.Z.; Tan, S.H.; Gañán-Calvo, A.M.; Tor, S.B.; Loh, N.H.; Nguyen, N.-T. Active Droplet Generation in Microfluidics. Lab Chip 2016, 16, 35–58. [Google Scholar] [CrossRef]
- Liu, J.; Fu, Q.; Li, Q.; Yang, Y.; Zhang, Y.; Yang, K.; Sun, G.; Luo, J.; Lu, W.; He, J. Research Strategies for Precise Manipulation of Micro/Nanoparticle Drug Delivery Systems Using Microfluidic Technology: A Review. Pharm. Front. 2024, 6, e69–e100. [Google Scholar] [CrossRef]
- Alavi, S.E.; Alharthi, S.; Alavi, S.F.; Zeinab Alavi, S.; Zahra, G.E.; Raza, A.; Shahmabadi, H.E. Microfluidics for Personalized Drug Delivery. Drug Discov. Today 2024, 29, 103936. [Google Scholar] [CrossRef]
- Baroud, C.N.; Gallaire, F.; Dangla, R. Dynamics of Microfluidic Droplets. Lab Chip 2010, 10, 2032. [Google Scholar] [CrossRef] [PubMed]
- Bianchi, J.R.D.O.; De La Torre, L.G.; Costa, A.L.R. Droplet-Based Microfluidics as a Platform to Design Food-Grade Delivery Systems Based on the Entrapped Compound Type. Foods 2023, 12, 3385. [Google Scholar] [CrossRef] [PubMed]
- Günther, A.; Jensen, K.F. Multiphase Microfluidics: From Flow Characteristics to Chemical and Materials Synthesis. Lab Chip 2006, 6, 1487–1503. [Google Scholar] [CrossRef]
- Raji, F.; Kahani, A.; Sahabi, M.; Rahbar-kalishami, A.; Padrela, L. Investigating the Effectiveness of the Main Channel in Microfluidic Liquid-Liquid Extraction Process. Int. Commun. Heat Mass Transf. 2023, 147, 106986. [Google Scholar] [CrossRef]
- Jiang, Z.; Shi, H.; Tang, X.; Qin, J. Recent Advances in Droplet Microfluidics for Single-Cell Analysis. TrAC Trends Anal. Chem. 2023, 159, 116932. [Google Scholar] [CrossRef]
- De Menech, M.; Garstecki, P.; Jousse, F.; Stone, H.A. Transition from Squeezing to Dripping in a Microfluidic T-Shaped Junction. J. Fluid Mech. 2008, 595, 141–161. [Google Scholar] [CrossRef]
- Kovalchuk, N.M.; Simmons, M.J.H. Review of the Role of Surfactant Dynamics in Drop Microfluidics. Adv. Colloid Interface Sci. 2023, 312, 102844. [Google Scholar] [CrossRef]
- Montanero, J.M.; Gañán-Calvo, A.M. Dripping, Jetting and Tip Streaming. Rep. Prog. Phys. 2020, 83, 097001. [Google Scholar] [CrossRef]
- Almeida, D.R.S.; Gil, J.F.; Guillot, A.J.; Li, J.; Pinto, R.J.B.; Santos, H.A.; Gonçalves, G. Advances in Microfluidic-based Core@Shell Nanoparticles Fabrication for Cancer Applications. Adv. Healthc. Mater. 2024, 2400946. [Google Scholar] [CrossRef]
- Fiorini, G.S.; Chiu, D.T. Disposable Microfluidic Devices: Fabrication, Function, and Application. BioTechniques 2005, 38, 429–446. [Google Scholar] [CrossRef]
- Scott, S.; Ali, Z. Fabrication Methods for Microfluidic Devices: An Overview. Micromachines 2021, 12, 319. [Google Scholar] [CrossRef] [PubMed]
- Aralekallu, S.; Boddula, R.; Singh, V. Development of Glass-Based Microfluidic Devices: A Review on Its Fabrication and Biologic Applications. Mater. Des. 2023, 225, 111517. [Google Scholar] [CrossRef]
- Mohammadi, M.; Ahmed Qadir, S.; Mahmood Faraj, A.; Hamid Shareef, O.; Mahmoodi, H.; Mahmoudi, F.; Moradi, S. Navigating the Future: Microfluidics Charting New Routes in Drug Delivery. Int. J. Pharm. 2024, 124142. [Google Scholar] [CrossRef]
- Niculescu, A.-G.; Chircov, C.; Bîrcă, A.C.; Grumezescu, A.M. Fabrication and Applications of Microfluidic Devices: A Review. Int. J. Mol. Sci. 2021, 22, 2011. [Google Scholar] [CrossRef]
- Elvira, K.S.; Gielen, F.; Tsai, S.S.H.; Nightingale, A.M. Materials and Methods for Droplet Microfluidic Device Fabrication. Lab Chip 2022, 22, 859–875. [Google Scholar] [CrossRef]
- Dendukuri, D.; Doyle, P.S. The Synthesis and Assembly of Polymeric Microparticles Using Microfluidics. Adv. Mater. 2009, 21, 4071–4086. [Google Scholar] [CrossRef]
- El Itawi, H.; Fadlallah, S.; Perré, P.; Allais, F. Microfluidics for Polymer Microparticles: Opinion on Sustainability and Scalability. Sustain. Chem. 2023, 4, 171–183. [Google Scholar] [CrossRef]
- Campos, E.; Branquinho, J.; Carreira, A.S.; Carvalho, A.; Coimbra, P.; Ferreira, P.; Gil, M.H. Designing Polymeric Microparticles for Biomedical and Industrial Applications. Eur. Polym. J. 2013, 49, 2005–2021. [Google Scholar] [CrossRef]
- Mok, J.H.; Niu, Y.; Zhao, Y. Continuous-Flow Viscoelastic Profiling of Calcium Alginate Hydrogel Microspheres Using a Microfluidic Lab-on-a-Chip Device. Food Hydrocoll. 2024, 153, 109979. [Google Scholar] [CrossRef]
- Yang, D.; Gao, K.; Bai, Y.; Lei, L.; Jia, T.; Yang, K.; Xue, C. Microfluidic Synthesis of Chitosan-Coated Magnetic Alginate Microparticles for Controlled and Sustained Drug Delivery. Int. J. Biol. Macromol. 2021, 182, 639–647. [Google Scholar] [CrossRef]
- Leontidou, T.; Yu, Z.; Hess, J.; Geisler, K.; Smith, A.G.; Coyne, A.; Abell, C. Microfluidic Preparation of Composite Hydrogel Microparticles for the Staining of Microalgal Cells. Colloids Surf. B Biointerfaces 2023, 221, 113026. [Google Scholar] [CrossRef] [PubMed]
- Zdunek, A.; Pieczywek, P.M.; Cybulska, J. The Primary, Secondary, and Structures of Higher Levels of Pectin Polysaccharides. Compr. Rev. Food Sci. Food Saf. 2021, 20, 1101–1117. [Google Scholar] [CrossRef] [PubMed]
- Wang, D.; Kanyuka, K.; Papp-Rupar, M. Pectin: A Critical Component in Cell-Wall-Mediated Immunity. Trends Plant Sci. 2023, 28, 10–13. [Google Scholar] [CrossRef] [PubMed]
- Voragen, A.G.J.; Coenen, G.-J.; Verhoef, R.P.; Schols, H.A. Pectin, a Versatile Polysaccharide Present in Plant Cell Walls. Struct. Chem. 2009, 20, 263–275. [Google Scholar] [CrossRef]
- Kaczmarska, A. Effect of Enzymatic Modification on the Structure and Rheological Properties of Diluted Alkali-Soluble Pectin Fraction Rich in RG-I. Sci. Rep. 2024, 14, 11454. [Google Scholar] [CrossRef] [PubMed]
- Sabater, C.; Villamiel, M.; Montilla, A. Integral Use of Pectin-Rich by-Products in a Biorefinery Context: A Holistic Approach. Food Hydrocoll. 2022, 128, 107564. [Google Scholar] [CrossRef]
- Reichembach, L.H.; Petkowicz, C.L.d.O. Pectins from Alternative Sources and Uses beyond Sweets and Jellies: An Overview. Food Hydrocoll. 2021, 118, 106824. [Google Scholar] [CrossRef]
- Toniazzo, T.; Fabi, J.P. Versatile Polysaccharides for Application to Semi-Solid and Fluid Foods: The Pectin Case. Fluids 2023, 8, 243. [Google Scholar] [CrossRef]
- Pedrosa, L.D.F.; Nascimento, K.R.; Soares, C.G.; Oliveira, D.P.D.; De Vos, P.; Fabi, J.P. Unveiling Plant-Based Pectins: Exploring the Interplay of Direct Effects, Fermentation, and Technological Applications in Clinical Research with a Focus on the Chemical Structure. Plants 2023, 12, 2750. [Google Scholar] [CrossRef] [PubMed]
- Cosgrove, D.J. Structure and Growth of Plant Cell Walls. Nat. Rev. Mol. Cell Biol. 2024, 25, 340–358. [Google Scholar] [CrossRef]
- Mohnen, D. Pectin Structure and Biosynthesis. Curr. Opin. Plant Biol. 2008, 11, 266–277. [Google Scholar] [CrossRef]
- Neelamegham, S.; Aoki-Kinoshita, K.; Bolton, E.; Frank, M.; Lisacek, F.; Lütteke, T.; O’Boyle, N.; Packer, N.H.; Stanley, P.; Toukach, P.; et al. Updates to the Symbol Nomenclature for Glycans Guidelines. Glycobiology 2019, 29, 620–624. [Google Scholar] [CrossRef]
- Riyamol; Gada Chengaiyan, J.; Rana, S.S.; Ahmad, F.; Haque, S.; Capanoglu, E. Recent Advances in the Extraction of Pectin from Various Sources and Industrial Applications. ACS Omega 2023, 8, 46309–46324. [Google Scholar] [CrossRef]
- Vasco-Correa, J.; Zapata Zapata, A.D. Enzymatic Extraction of Pectin from Passion Fruit Peel (Passiflora Edulis f. Flavicarpa) at Laboratory and Bench Scale. LWT 2017, 80, 280–285. [Google Scholar] [CrossRef]
- Mao, Y.; Robinson, J.P.; Binner, E.R. Current Status of Microwave-Assisted Extraction of Pectin. Chem. Eng. J. 2023, 473, 145261. [Google Scholar] [CrossRef]
- Liu, D.; Xia, W.; Liu, J.; Wang, X.; Xue, J. Ultrasound-Assisted Alkali Extraction of RG-I Enriched Pectin from Thinned Young Apples: Structural Characterization and Gelling Properties. Food Hydrocoll. 2024, 151, 109879. [Google Scholar] [CrossRef]
- Sharifi, A.; Hamidi-Esfahani, Z.; Ahmadi Gavlighi, H.; Saberian, H. Assisted Ohmic Heating Extraction of Pectin from Pomegranate Peel. Chem. Eng. Process.—Process Intensif. 2022, 172, 108760. [Google Scholar] [CrossRef]
- Yilmaz-Turan, S.; Gál, T.; Lopez-Sanchez, P.; Martinez, M.M.; Menzel, C.; Vilaplana, F. Modulating Temperature and pH during Subcritical Water Extraction Tunes the Molecular Properties of Apple Pomace Pectin as Food Gels and Emulsifiers. Food Hydrocoll. 2023, 145, 109148. [Google Scholar] [CrossRef]
- Turan, O.; Isci, A.; Yılmaz, M.S.; Tolun, A.; Sakiyan, O. Microwave-Assisted Extraction of Pectin from Orange Peel Using Deep Eutectic Solvents. Sustain. Chem. Pharm. 2024, 37, 101352. [Google Scholar] [CrossRef]
- Braccini, I.; Pérez, S. Molecular Basis of Ca2+ -Induced Gelation in Alginates and Pectins: The Egg-Box Model Revisited. Biomacromolecules 2001, 2, 1089–1096. [Google Scholar] [CrossRef] [PubMed]
- Cao, L.; Lu, W.; Mata, A.; Nishinari, K.; Fang, Y. Egg-Box Model-Based Gelation of Alginate and Pectin: A Review. Carbohydr. Polym. 2020, 242, 116389. [Google Scholar] [CrossRef] [PubMed]
- Marić, M.; Grassino, A.N.; Zhu, Z.; Barba, F.J.; Brnčić, M.; Rimac Brnčić, S. An Overview of the Traditional and Innovative Approaches for Pectin Extraction from Plant Food Wastes and By-Products: Ultrasound-, Microwaves-, and Enzyme-Assisted Extraction. Trends Food Sci. Technol. 2018, 76, 28–37. [Google Scholar] [CrossRef]
- Tan, H.; Nie, S. Deciphering Diet-Gut Microbiota-Host Interplay: Investigations of Pectin. Trends Food Sci. Technol. 2020, 106, 171–181. [Google Scholar] [CrossRef]
- Tang, X.; De Vos, P. Structure-Function Effects of Different Pectin Chemistries and Its Impact on the Gastrointestinal Immune Barrier System. Crit. Rev. Food Sci. Nutr. 2023, 1–15. [Google Scholar] [CrossRef] [PubMed]
- Cao, W.; Guan, S.; Yuan, Y.; Wang, Y.; Mst Nushrat, Y.; Liu, Y.; Tong, Y.; Yu, S.; Hua, X. The Digestive Behavior of Pectin in Human Gastrointestinal Tract: A Review on Fermentation Characteristics and Degradation Mechanism. Crit. Rev. Food Sci. Nutr. 2023, 1–24. [Google Scholar] [CrossRef]
- Brouns, F.; Theuwissen, E.; Adam, A.; Bell, M.; Berger, A.; Mensink, R.P. Cholesterol-Lowering Properties of Different Pectin Types in Mildly Hyper-Cholesterolemic Men and Women. Eur. J. Clin. Nutr. 2012, 66, 591–599. [Google Scholar] [CrossRef] [PubMed]
- Pedrosa, L.D.F.; Fabi, J.P. Dietary Fiber as a Wide Pillar of Colorectal Cancer Prevention and Adjuvant Therapy. Crit. Rev. Food Sci. Nutr. 2023, 64, 6177–6197. [Google Scholar] [CrossRef]
- Das, S. Pectin Based Multi-Particulate Carriers for Colon-Specific Delivery of Therapeutic Agents. Int. J. Pharm. 2021, 605, 120814. [Google Scholar] [CrossRef]
- Zhang, W.; Zhou, Z. Citrus Pectin-Derived Carbon Microspheres with Superior Adsorption Ability for Methylene Blue. Nanomaterials 2017, 7, 161. [Google Scholar] [CrossRef]
- Michel, C.R.; Martínez-Preciado, A.H. CO Sensing Properties of Novel Nanostructured La2O3 Microspheres. Sens. Actuators B Chem. 2015, 208, 355–362. [Google Scholar] [CrossRef]
- Chou, W.-M.; Wang, L.-L.; Yu, H.H. Electrophoretic Ink Display Prepared by Jelly Fig Pectin/Gelatin Microspheres. Smart Sci. 2015, 3, 74–79. [Google Scholar] [CrossRef]
- Zamri, N.I.I.; Zulmajdi, S.L.N.; Daud, N.Z.A.; Mahadi, A.H.; Kusrini, E.; Usman, A. Insight into the Adsorption Kinetics, Mechanism, and Thermodynamics of Methylene Blue from Aqueous Solution onto Pectin-Alginate-Titania Composite Microparticles. SN Appl. Sci. 2021, 3, 222. [Google Scholar] [CrossRef]
- Munarin, F.; Giuliano, L.; Bozzini, S.; Tanzi, M.C.; Petrini, P. Mineral Phase Deposition on Pectin Microspheres. Mater. Sci. Eng. C 2010, 30, 491–496. [Google Scholar] [CrossRef]
- Dini, C.; Islan, G.A.; De Urraza, P.J.; Castro, G.R. Novel Biopolymer Matrices for Microencapsulation of Phages: Enhanced Protection Against Acidity and Protease Activity. Macromol. Biosci. 2012, 12, 1200–1208. [Google Scholar] [CrossRef] [PubMed]
- Wang, R.; Li, Y.; Shuai, X.; Liang, R.; Chen, J.; Liu, C. Pectin/Activated Carbon-Based Porous Microsphere for Pb2+ Adsorption: Characterization and Adsorption Behaviour. Polymers 2021, 13, 2453. [Google Scholar] [CrossRef] [PubMed]
- Liu, Y.; Sun, Y.; Ding, G.; Geng, Q.; Zhu, J.; Guo, M.; Duan, Y.; Wang, B.; Cao, Y. Synthesis, Characterization, and Application of Microbe-Triggered Controlled-Release Kasugamycin–Pectin Conjugate. J. Agric. Food Chem. 2015, 63, 4263–4268. [Google Scholar] [CrossRef] [PubMed]
- Hu, K.; Huang, X.; Gao, Y.; Huang, X.; Xiao, H.; McClements, D.J. Core–Shell Biopolymer Nanoparticle Delivery Systems: Synthesis and Characterization of Curcumin Fortified Zein–Pectin Nanoparticles. Food Chem. 2015, 182, 275–281. [Google Scholar] [CrossRef] [PubMed]
- Zhou, F.-Z.; Huang, X.-N.; Wu, Z.; Yin, S.-W.; Zhu, J.; Tang, C.-H.; Yang, X.-Q. Fabrication of Zein/Pectin Hybrid Particle-Stabilized Pickering High Internal Phase Emulsions with Robust and Ordered Interface Architecture. J. Agric. Food Chem. 2018, 66, 11113–11123. [Google Scholar] [CrossRef] [PubMed]
- Nguyen, T.T.; Miyauchi, M.; Rahmatika, A.M.; Cao, K.L.A.; Tanabe, E.; Ogi, T. Enhanced Protein Adsorption Capacity of Macroporous Pectin Particles with High Specific Surface Area and an Interconnected Pore Network. ACS Appl. Mater. Interfaces 2022, 14, 14435–14446. [Google Scholar] [CrossRef] [PubMed]
- Méndez, D.A.; Schroeter, B.; Martínez-Abad, A.; Fabra, M.J.; Gurikov, P.; López-Rubio, A. Pectin-Based Aerogel Particles for Drug Delivery: Effect of Pectin Composition on Aerogel Structure and Release Properties. Carbohydr. Polym. 2023, 306, 120604. [Google Scholar] [CrossRef] [PubMed]
- Nguyen, T.T.; Saipul Bahri, N.S.N.; Rahmatika, A.M.; Cao, K.L.A.; Hirano, T.; Ogi, T. Rapid Indomethacin Release from Porous Pectin Particles as a Colon-Targeted Drug Delivery System. ACS Appl. Bio Mater. 2023, 6, 2725–2737. [Google Scholar] [CrossRef] [PubMed]
- Osvaldt Rosales, T.K.; Pessoa da Silva, M.; Lourenço, F.R.; Aymoto Hassimotto, N.M.; Fabi, J.P. Nanoencapsulation of Anthocyanins from Blackberry (Rubus Spp.) through Pectin and Lysozyme Self-Assembling. Food Hydrocoll. 2021, 114, 106563. [Google Scholar] [CrossRef]
- Da Silva, M.P.; Rosales, T.K.O.; de Pedrosa, L.F.; Fabi, J.P. Creation of a New Proof-of-Concept Pectin/Lysozyme Nanocomplex as Potential β-Lactose Delivery Matrix: Structure and Thermal Stability Analyses. Food Hydrocoll. 2023, 134, 108011. [Google Scholar] [CrossRef]
- Han, S.S.; Ji, S.M.; Park, M.J.; Suneetha, M.; Uthappa, U.T. Pectin Based Hydrogels for Drug Delivery Applications: A Mini Review. Gels 2022, 8, 834. [Google Scholar] [CrossRef]
- Li, D.; Li, J.; Dong, H.; Li, X.; Zhang, J.; Ramaswamy, S.; Xu, F. Pectin in Biomedical and Drug Delivery Applications: A Review. Int. J. Biol. Macromol. 2021, 185, 49–65. [Google Scholar] [CrossRef]
- Gutierrez-Alvarado, K.; Chacón-Cerdas, R.; Starbird-Perez, R. Pectin Microspheres: Synthesis Methods, Properties, and Their Multidisciplinary Applications. Chemistry 2022, 4, 121–136. [Google Scholar] [CrossRef]
- Huang, M.; Sun, Y.; Tan, C. Recent Advances in Emerging Pectin-Derived Nanocarriers for Controlled Delivery of Bioactive Compounds. Food Hydrocoll. 2023, 140, 108682. [Google Scholar] [CrossRef]
- Aydin, Z.; Akbugˇa, J. Preparation and Evaluation of Pectin Beads. Int. J. Pharm. 1996, 137, 133–136. [Google Scholar] [CrossRef]
- Günter, E.A.; Popeyko, O.V. Calcium Pectinate Gel Beads Obtained from Callus Cultures Pectins as Promising Systems for Colon-Targeted Drug Delivery. Carbohydr. Polym. 2016, 147, 490–499. [Google Scholar] [CrossRef]
- de Moura, S.C.S.R.; Berling, C.L.; Germer, S.P.M.; Alvim, I.D.; Hubinger, M.D. Encapsulating Anthocyanins from Hibiscus Sabdariffa L. Calyces by Ionic Gelation: Pigment Stability during Storage of Microparticles. Food Chem. 2018, 241, 317–327. [Google Scholar] [CrossRef] [PubMed]
- Sampaio, G.L.A.; Pacheco, S.; Ribeiro, A.P.O.; Galdeano, M.C.; Gomes, F.S.; Tonon, R.V. Encapsulation of a Lycopene-Rich Watermelon Concentrate in Alginate and Pectin Beads: Characterization and Stability. LWT 2019, 116, 108589. [Google Scholar] [CrossRef]
- Heumann, A.; Assifaoui, A.; Da Silva Barreira, D.; Thomas, C.; Briandet, R.; Laurent, J.; Beney, L.; Lapaquette, P.; Guzzo, J.; Rieu, A. Intestinal Release of Biofilm-like Microcolonies Encased in Calcium-Pectinate Beads Increases Probiotic Properties of Lacticaseibacillus Paracasei. npj Biofilms Microbiomes 2020, 6, 44. [Google Scholar] [CrossRef]
- Cava, E.L.; Gerbino, E.; Sgroppo, S.C.; Gómez-Zavaglia, A. Pectin Hydrolysates from Different Cultivars of Pink/Red and White Grapefruits (Citrus Paradisi [Macf.]) as Culture and Encapsulating Media for Lactobacillus Plantarum. J. Food Sci. 2019, 84, 1776–1783. [Google Scholar] [CrossRef]
- Raghav, N.; Vashisth, C.; Mor, N.; Arya, P.; Sharma, M.R.; Kaur, R.; Bhatti, S.P.; Kennedy, J.F. Recent Advances in Cellulose, Pectin, Carrageenan and Alginate-Based Oral Drug Delivery Systems. Int. J. Biol. Macromol. 2023, 244, 125357. [Google Scholar] [CrossRef]
- Souza, F.N.; Gebara, C.; Ribeiro, M.C.E.; Chaves, K.S.; Gigante, M.L.; Grosso, C.R.F. Production and Characterization of Microparticles Containing Pectin and Whey Proteins. Food Res. Int. 2012, 49, 560–566. [Google Scholar] [CrossRef]
- Lemos, T.S.A.; De Souza, J.F.; Fajardo, A.R. Magnetic Microspheres Based on Pectin Coated by Chitosan towards Smart Drug Release. Carbohydr. Polym. 2021, 265, 118013. [Google Scholar] [CrossRef]
- Günter, E.A.; Popeyko, O.V.; Belozerov, V.S.; Martinson, E.A.; Litvinets, S.G. Physicochemical and Swelling Properties of Composite Gel Microparticles Based on Alginate and Callus Cultures Pectins with Low and High Degrees of Methylesterification. Int. J. Biol. Macromol. 2020, 164, 863–870. [Google Scholar] [CrossRef]
- Ngouémazong, E.D.; Christiaens, S.; Shpigelman, A.; Van Loey, A.; Hendrickx, M. The Emulsifying and Emulsion-Stabilizing Properties of Pectin: A Review. Comp. Rev. Food Sci. Food Safe 2015, 14, 705–718. [Google Scholar] [CrossRef]
- Feng, L.; Wang, Y.; Liu, T.; Zhao, C.; Chen, Y.; Wang, F.; Bao, Y.; Zheng, J. Pectin-Based Emulsion Gels Prepared by Acidic and Ionotropic Methods for Intestinal Targeted Delivery in Vitro. Food Hydrocoll. 2024, 154, 110118. [Google Scholar] [CrossRef]
- Ogończyk, D.; Siek, M.; Garstecki, P. Microfluidic Formulation of Pectin Microbeads for Encapsulation and Controlled Release of Nanoparticles. Biomicrofluidics 2011, 5, 013405. [Google Scholar] [CrossRef]
- Marquis, M.; Renard, D.; Cathala, B. Microfluidic Generation and Selective Degradation of Biopolymer-Based Janus Microbeads. Biomacromolecules 2012, 13, 1197–1203. [Google Scholar] [CrossRef]
- Marquis, M.; Davy, J.; Cathala, B.; Fang, A.; Renard, D. Microfluidics Assisted Generation of Innovative Polysaccharide Hydrogel Microparticles. Carbohydr. Polym. 2015, 116, 189–199. [Google Scholar] [CrossRef] [PubMed]
- Marquis, M.; Davy, J.; Fang, A.; Renard, D. Microfluidics-Assisted Diffusion Self-Assembly: Toward the Control of the Shape and Size of Pectin Hydrogel Microparticles. Biomacromolecules 2014, 15, 1568–1578. [Google Scholar] [CrossRef] [PubMed]
- Fang, A.; Cathala, B. Smart Swelling Biopolymer Microparticles by a Microfluidic Approach: Synthesis, in Situ Encapsulation and Controlled Release. Colloids Surf. B Biointerfaces 2011, 82, 81–86. [Google Scholar] [CrossRef]
- Kim, C.; Park, K.; Kim, J.; Jeong, S.; Lee, C. Microfluidic Synthesis of Monodisperse Pectin Hydrogel Microspheres Based on in Situ Gelation and Settling Collection. J. Chem. Technol. Biotechnol. 2017, 92, 201–209. [Google Scholar] [CrossRef]
- Noh, J.; Kim, J.; Kim, J.S.; Chung, Y.S.; Chang, S.T.; Park, J. Microencapsulation by Pectin for Multi-Components Carriers Bearing Both Hydrophobic and Hydrophilic Active Agents. Carbohydr. Polym. 2018, 182, 172–179. [Google Scholar] [CrossRef]
- Rajabnejad Keleshteri, A.; Moztarzadeh, F.; Farokhi, M.; Mehrizi, A.A.; Basiri, H.; Mohseni, S.S. Preparation of Microfluidic-Based Pectin Microparticles Loaded Carbon Dots Conjugated with BMP-2 Embedded in Gelatin-Elastin-Hyaluronic Acid Hydrogel Scaffold for Bone Tissue Engineering Application. Int. J. Biol. Macromol. 2021, 184, 29–41. [Google Scholar] [CrossRef]
- Wang, Y.; Lin, A.; Yan, Z.; Shen, B.; Zhu, L.; Jiang, L. Enhanced Tolerance to Environmental Stress of Clostridium Butyricum Spore Encapsulated in Citrus Peel Pectin Polysaccharide for Colitis Therapy. Food Biosci. 2024, 60, 104436. [Google Scholar] [CrossRef]
- Wang, M.; Cheng, Y.; Li, X.; Nian, L.; Yuan, B.; Cheng, S.; Wang, S.; Cao, C. Effects of Microgels Fabricated by Microfluidic on the Stability, Antioxidant, and Immunoenhancing Activities of Aquatic Protein. J. Future Foods 2025, 5, 57–67. [Google Scholar] [CrossRef]
- Kawakatsu, T.; Trägårdh, G.; Trägårdh, C. Production of W/O/W Emulsions and S/O/W Pectin Microcapsules by Microchannel Emulsification. Colloids Surf. A Physicochem. Eng. Asp. 2001, 189, 257–264. [Google Scholar] [CrossRef]
- Vladisavljević, G.T.; Kobayashi, I.; Nakajima, M. Production of Uniform Droplets Using Membrane, Microchannel and Microfluidic Emulsification Devices. Microfluid. Nanofluid. 2012, 13, 151–178. [Google Scholar] [CrossRef]
- Cheung, R.; Ng, T.; Wong, J. Marine Peptides: Bioactivities and Applications. Mar. Drugs 2015, 13, 4006–4043. [Google Scholar] [CrossRef] [PubMed]
- Venkatesan, J.; Anil, S.; Kim, S.-K.; Shim, M. Marine Fish Proteins and Peptides for Cosmeceuticals: A Review. Mar. Drugs 2017, 15, 143. [Google Scholar] [CrossRef]
- Zhang, W.; Boateng, I.D.; Xu, J. Novel Marine Proteins as a Global Protein Supply and Human Nutrition: Extraction, Bioactivities, Potential Applications, Safety Assessment, and Deodorization Technologies. Trends Food Sci. Technol. 2024, 143, 104283. [Google Scholar] [CrossRef]
- Nadine, S.; Chung, A.; Diltemiz, S.E.; Yasuda, B.; Lee, C.; Hosseini, V.; Karamikamkar, S.; De Barros, N.R.; Mandal, K.; Advani, S.; et al. Advances in Microfabrication Technologies in Tissue Engineering and Regenerative Medicine. Artif. Organs 2022, 46, E211–E243. [Google Scholar] [CrossRef]
- Sherstneva, A.A.; Demina, T.S.; Monteiro, A.P.F.; Akopova, T.A.; Grandfils, C.; Ilangala, A.B. Biodegradable Microparticles for Regenerative Medicine: A State of the Art and Trends to Clinical Application. Polymers 2022, 14, 1314. [Google Scholar] [CrossRef] [PubMed]
- Poon, B.; Kha, T.; Tran, S.; Dass, C.R. Bone Morphogenetic Protein-2 and Bone Therapy: Successes and Pitfalls. J. Pharm. Pharmacol. 2016, 68, 139–147. [Google Scholar] [CrossRef]
- Halloran, D.; Durbano, H.W.; Nohe, A. Bone Morphogenetic Protein-2 in Development and Bone Homeostasis. J. Dev. Biol. 2020, 8, 19. [Google Scholar] [CrossRef] [PubMed]
- Gupta, M.; Kapoor, B.; Gulati, M. Bacterial Consortia-The Latest Arsenal to Inflammatory Bowel Disease Bacteriotherapy. Med. Microecol. 2024, 20, 100107. [Google Scholar] [CrossRef]
- De Gennes, P.G. Soft Matter. Science 1992, 256, 495–497. [Google Scholar] [CrossRef]
- Su, H.; Hurd Price, C.-A.; Jing, L.; Tian, Q.; Liu, J.; Qian, K. Janus Particles: Design, Preparation, and Biomedical Applications. Mater. Today Bio 2019, 4, 100033. [Google Scholar] [CrossRef]
- Walther, A.; Müller, A.H.E. Janus Particles: Synthesis, Self-Assembly, Physical Properties, and Applications. Chem. Rev. 2013, 113, 5194–5261. [Google Scholar] [CrossRef]
- Hu, J.; Zhou, S.; Sun, Y.; Fang, X.; Wu, L. Fabrication, Properties and Applications of Janus Particles. Chem. Soc. Rev. 2012, 41, 4356. [Google Scholar] [CrossRef]
Dimensionless Numbers | Physical Meanings * | Equations ** |
---|---|---|
Reynolds number (Re) | Inertial force/viscous force | |
Capillary number (Ca) | Viscous force/interfacial tension | |
Weber number (We) | Inertial force/interfacial tension | |
Bond number (Bo) | Buoyancy/interfacial tension |
Gelation Mechanism | MP Structure | Droplet TYPE | Cargo | Particle Diameter | Effects | Refs. |
---|---|---|---|---|---|---|
Internal gelation | Spherical | W/O | Gold particles | <1.0 mm | Controlled release | [118] |
Janus particles | W/O | BSA | 92.0 μm | Multidrug delivery | [119,120] | |
Spherical, doughnut-like, and ellipsoidal | W/O | - | 18.0–42.0 μm | Smart swelling | [121] | |
Spherical | W/O | - | 40.0–100.0 µm | Smart swelling | [122] | |
External gelation | Spherical, doughnut-like, and anisotropic | W/O | - | 22.0–200.0 μm | Smart swelling | [121] |
Spherical and ellipsoidal | W/O | Fe2O3 | 55.0–100.0 μm | Magnetic anisotropy | [123] | |
Spherical | O/W | Retinyl palmitate and quercetin | 67.3–103.4 μm | Multidrug delivery | [124] | |
Spherical | W/O | BMP-2-CDs | 35.0 μm | Sustained delivery system | [125] | |
Spherical | W/O | Vegetative cells and spores of Clostridium butyricum | 282.1–362.8 µm | Maintained viability | [126] | |
Spherical | W/O | FCWP and LJWP | 120.0 μm | Sustained delivery system | [127] |
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Silva, P.B.V.d.; Fabi, J.P. Overview of Pectin-Derived Microparticles through Microfluidic Technology. Fluids 2024, 9, 184. https://doi.org/10.3390/fluids9080184
Silva PBVd, Fabi JP. Overview of Pectin-Derived Microparticles through Microfluidic Technology. Fluids. 2024; 9(8):184. https://doi.org/10.3390/fluids9080184
Chicago/Turabian StyleSilva, Pedro Brivaldo Viana da, and João Paulo Fabi. 2024. "Overview of Pectin-Derived Microparticles through Microfluidic Technology" Fluids 9, no. 8: 184. https://doi.org/10.3390/fluids9080184