Stratifying Intraductal Papillary Mucinous Neoplasms by Cyst Fluid Analysis: Present and Future
Abstract
:1. Introduction
2. Single Marker Analyses
2.1. Mucins
2.2. IL-1b
2.3. PGE2
2.4. Telomere Fusion Status
2.5. miR-216a
2.6. CEP and mAb Das-1
3. Panel Analyses
3.1. Mutational Analysis: KRAS, GNAS, and Cytopathology
3.2. Next-Generation Sequencing Panel: KRAS, GNAS, TP53, PIK3CA, and PTEN
3.3. Whole Exome Sequencing: SMAD4, RNF43, Chromosomal Aneuploidy, and TP53
3.4. Proteomic Array: MMP9, CA72-4, sFASL, and IL-4
3.5. Biosignatures
4. Nomograms and Algorithms: Combining Clinical Features and Biomarker Analyses
4.1. Nomogram
4.2. MOCA Algorithm
4.3. IMP Testing
5. Future Directions
Author Contributions
Funding
Conflicts of Interest
Abbreviations
IPMN | Intraductal papillary mucinous neoplasm |
CT | Computed tomography |
MRI | Magnetic resonance imaging |
MRCP | Magnetic resonance cholangiopancreatography |
PDAC | Pancreatic ductal adenocarcinoma |
ICG | International consensus guidelines |
MD-IPMN | Main duct IPMN |
BD-IPMN | Branch duct IPMN |
MPD | Main pancreatic duct |
AGA | American Gastroenterological Association |
EUS | Endoscopic ultrasound |
FNA | Fine needle aspiration |
HGD | High-grade dysplasia |
CEA | Carcinoembryonic antigen |
SCA | Serous cystadenoma |
SPN | Solid pseudo-papillary neoplasm |
MCN | Mucinous cystic neoplasm |
GNAS | Guanine nucleotide binding protein, alpha-stimulating |
KRAS | Kirsten rat sarcoma viral oncogene homolog |
NGAL | neutrophil gelatinase-associated lipocalin |
MUC | Mucin |
IL | Interleukin |
PGE2 | Prostaglandin E2 |
ELISA | Enzyme-linked immunosorbent assay |
NSAID | Nonsteroidal anti-inflammatory drug |
LGD | Low-grade dysplasia |
miRNA | MicroRNA |
NGS | Next Generation Sequencing |
mAb | Monoclonal antibody |
CEP | Colon epithelial protein |
PCR | Polymerase chain reaction |
LOH | Loss of heterozygosity |
MOCA | Multivariate organization of combinatorial alterations |
IMP | Integrated molecular pathology |
PANCAN | Pancreatic Cancer Action Network |
NCI | National Cancer Institute |
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Amylase < 250 | Amylase > 250 | |
---|---|---|
CEA < 192 | SCA | Pseudocyst |
CEA > 192 | MCN | IPMN |
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Hao, S.; Takahashi, C.; Snyder, R.A.; Parikh, A.A. Stratifying Intraductal Papillary Mucinous Neoplasms by Cyst Fluid Analysis: Present and Future. Int. J. Mol. Sci. 2020, 21, 1147. https://doi.org/10.3390/ijms21031147
Hao S, Takahashi C, Snyder RA, Parikh AA. Stratifying Intraductal Papillary Mucinous Neoplasms by Cyst Fluid Analysis: Present and Future. International Journal of Molecular Sciences. 2020; 21(3):1147. https://doi.org/10.3390/ijms21031147
Chicago/Turabian StyleHao, Scarlett, Caitlin Takahashi, Rebecca A. Snyder, and Alexander A. Parikh. 2020. "Stratifying Intraductal Papillary Mucinous Neoplasms by Cyst Fluid Analysis: Present and Future" International Journal of Molecular Sciences 21, no. 3: 1147. https://doi.org/10.3390/ijms21031147