MicroRNA Modulation of Host Immune Response and Inflammation Triggered by Helicobacter pylori
Abstract
:1. Introduction
2. Helicobacter pylori, Virulence Factors, and Host Immune Response
3. Helicobacter pylori—Driven Pathways of Gastric Carcinogenesis
4. MiRNAs as Modulators of Innate Immune Response and H. pylori Associated Inflammation
4.1. Let-7 Family of miRNAs
4.2. MiRNA-155
4.3. MiRNA-146
4.4. MiRNA-125
4.5. MiRNA-21
4.6. MiRNA-223
4.7. Other miRNAs and H. pylori
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
AP-1 | activator protein 1 |
ARID1A | AT-rich interacting domain containing protein 1A |
BRMS1 | breast cancer metastasis suppressor 1 |
CagA | cytotoxin-associated gene A |
CAMP | cationic antimicrobial peptide |
EMT | Epithelial–mesenchymal transition |
GRO | growth-related oncogene |
H. pylori | Helicobacter pylori |
HP-NAP | Helicobacter pylori neutrophil-activating protein |
ICAM-1 | intercellular adhesion molecule-1 |
IFNγ | interferon γ |
IL | interleukin |
IRAK1 | IL-1 receptor associated kinase 1 |
Let-7 | lethal 7 |
LPS | lipopolysaccharide |
MALT | mucosa-associated lymphoid tissue |
MAPK | mitogen-activated protein kinase |
MHC | major histocompatibility complex |
MIP | macrophage inflammatory protein |
miRNA | microRNA |
mRNA | messenger RNA |
NF-kB | nuclear factor-kappa B |
NOX1 | neutrophil NADPH oxidase |
PAMP | pathogen-associated molecular pattern |
PDCD4 | programmed cell death protein 4 |
PRM | pattern-recognition molecule |
ROS | reactive oxygen species |
T4SS | type IV secretion system |
Th | T helper cells |
TLR | toll-like receptor |
TRAF6 | tumor necrosis factor receptor associated factor-6 |
TNF | tumor necrosis factor |
UTR | untranslated region |
VacA | vacuolating cytotoxin |
VEGF | vascular endothelial growth factor |
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Săsăran, M.O.; Meliț, L.E.; Dobru, E.D. MicroRNA Modulation of Host Immune Response and Inflammation Triggered by Helicobacter pylori. Int. J. Mol. Sci. 2021, 22, 1406. https://doi.org/10.3390/ijms22031406
Săsăran MO, Meliț LE, Dobru ED. MicroRNA Modulation of Host Immune Response and Inflammation Triggered by Helicobacter pylori. International Journal of Molecular Sciences. 2021; 22(3):1406. https://doi.org/10.3390/ijms22031406
Chicago/Turabian StyleSăsăran, Maria Oana, Lorena Elena Meliț, and Ecaterina Daniela Dobru. 2021. "MicroRNA Modulation of Host Immune Response and Inflammation Triggered by Helicobacter pylori" International Journal of Molecular Sciences 22, no. 3: 1406. https://doi.org/10.3390/ijms22031406