Human Papillomavirus in Oral Lichen Planus: Is There an Association? A Meta-Analysis
Abstract
:1. Introduction
2. Results
2.1. Overall Information on the Studies Included
2.2. Quality Assessment
2.3. Meta-Analysis
3. Discussion
4. Materials and Methods
4.1. Search Strategy
4.2. Quality Assessment
5. Conclusions
Author Contributions
Funding
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Author | Country | Cases (LP) | Controls | HPV+ Cases | HPV+ Controls | Types of HPV Tested | Type of LP | HPV+ Cases/LP Type |
---|---|---|---|---|---|---|---|---|
Campisi G. et al. (2004) [35] | Italy | 71 | 90 | 14 | 5 | 6, 16, 18, 31, 33 | AE/n-AE | AE HPV+ 9 n-AE HPV+ 5 |
Farhadi S. et al. (2020) [38] | Iran | 32 | 20 | 8 | 0 | 11, 16, 18, 33–73 | AE/n-AE | AE HPV+ 8 n-AE+ 0 |
Maitland NJ. et al. (1987) [18] | UK | 8 | 12 | 7 | 5 | 16 | NA | NA |
Mohhamadi M. et al. (2023) [6] | Iran | 25 | 25 | 14 | 7 | 16, 18 | AE/n-AE | AE HPV+ 8 n-AE HPV+ 6 |
Nafarzadeh S. et al. (2017) [31] | Iran | 50 | 7 | 30 | 1 | NA | NA | NA |
Pierangeli A. et al. (2016) [36] | Italy | 12 | 54 | 9 | 19 | 6, 11, 16, 18, 31, 33, 53, 58 | NA | NA |
Pol CA. et al. (2015) [28] | India | 30 | 30 | 21 | 0 | 16 | n-AE | n-AE HPV+ 21 |
Razavi SM. et al. (2009) [32] | Iran | 29 | 9 | 14 | 1 | 18 | NA | NA |
Radochova V. et al. (2015) [33] | Czech Republic | 45 | 24 | 24 | 14 | 6, 11, 16, 18, 26, 31, 33, 35, 39, 40, 42, 45, 51–56, 58, 59, 61, 62, 64, 66–73, 81–84, IS39, CP6108 | AE/n-AE | AE HPV+ 16 n-AE HPV+ 8 |
Sameera A. et al. (2015) [30] | India | 15 | 15 | 13 | 0 | 18 | AE/n-AE | AE HPV+ 5 n-AE HPV+ 8 |
Szarka K. et al. (2009) [34] | Hungary | 119 | 72 | 39 | 3 | 6, 11, 16, 18, 31, 33 | AE/n-AE | AE HPV+ 26 n-AE HPV+ 13 |
Yildirim B. et al. (2012) [15] | Turkey | 65 | 15 | 14 | 0 | 16 | NA | NA |
Zendeli-Bedejeti L. et al. (2019) [37] | Macedonia | 40 | 40 | 12 | 1 | 16, 18, 31, 33, 35, 39, 45, 51, 52, 56–59 | NA | NA |
Reference | Selection | Comparability | Exposure | Total | ||||||
---|---|---|---|---|---|---|---|---|---|---|
1 | 2 | 3 | 4 | 1 (Age) | 2 (Other) | 1 | 2 | 3 | ||
Campisi G. et al. (2004) [35] | * | * | * | * | * | * | * | * | * | 9 |
Farhadi S. et al. (2020) [38] | * | * | * | * | * 1 | 0 | * | * | * | 8 1 |
Maitland NJ. et al. (1987) [18] | * | * | * | * | 0 | 0 | * | * | * | 7 |
Mohhamadi M. et al. (2023) [6] | * | * | * | * | * | * | * | * | * | 9 |
Nafarzadeh S. et al. (2017) [31] | * | * | 0 | * | 0 1 | 0 1 | * | * | * | 6 1 |
Pierangeli A. et al. (2016) [36] | * | * | * | * | * | * | * | * | * | 9 |
Pol CA. et al. (2015) [28] | * | * | * | * | * | * | * | * | * | 9 |
Razavi SM. et al. (2009) [32] | * | * | * | * | 0 | * | * | * | * | 8 |
Radochova V. et al. (2015) [33] | * | * | * | * | * | * | * | * | * | 9 |
Sameera A. et al. (2015) [30] | * | * | * | * | 0 | 0 1 | * | * | * | 7 1 |
Szarka K. et al. (2009) [34] | * | * | * | * | * | 0 | * | * | * | 8 |
Yildirim B. et al. (2012) [15] | * | * | * | * | 0 | 0 | * | * | * | 7 |
Zendeli-Bedejeti L. et al. (2019) [37] | * | * | * | * | 0 1 | 0 | * | * | * | 7 1 |
Raw Data | Fill and Trim | |
---|---|---|
Tau2 | 0.3937 | 0.8279 |
I2 | 41.62% | 55.74% |
H2 | 1.71 | 2.26 |
Test for heterogeneity | ||
Q | 20.1027 | 40.3356 |
p-val | 0.0652 | 0.0019 |
Estimate | Standard Error | z-Val | p-Val | ci.lb | ci.ub | Q | Qp | Tau2 | I2 | H2 | |
---|---|---|---|---|---|---|---|---|---|---|---|
Szarka K. et al. (2009) [34] | 1.14 | 0.29 | 3.8885 | 0.0001 | 0.57 | 1.71 | 16.93 | 0.11 | 0.33 | 36.02 | 1.56 |
Campisi G. et al. (2004) [35] | 1.31 | 0.33 | 3.9855 | 0.0001 | 0.66 | 1.95 | 19.87 | 0.05 | 0.51 | 46.09 | 1.85 |
Mohhamadi M. et al. (2023) [6] | 1.38 | 0.32 | 4.2424 | 0.0000 | 0.74 | 2.01 | 19.68 | 0.05 | 0.49 | 45.01 | 1.82 |
Pol CA. et al. (2015) [28] | 1.15 | 0.28 | 4.1410 | 0.0000 | 0.61 | 1.70 | 16.48 | 0.12 | 0.31 | 37.47 | 1.60 |
Yildirim B. et al. (2012) [15] | 1.25 | 0.30 | 4.2133 | 0.0000 | 0.67 | 1.83 | 19.72 | 0.05 | 0.41 | 43.94 | 1.78 |
Maitland NJ. et al. (1987) [18] | 1.35 | 0.32 | 4.2361 | 0.0000 | 0.72 | 1.97 | 19.95 | 0.05 | 0.48 | 46.58 | 1.87 |
Nafarzadeh S. et al. (2017) [31] | 1.27 | 0.30 | 4.1718 | 0.0000 | 0.67 | 1.87 | 19.96 | 0.05 | 0.44 | 45.38 | 1.83 |
Farhadi S. et al. (2020) [38] | 1.23 | 0.29 | 4.1908 | 0.0000 | 0.65 | 1.80 | 19.26 | 0.06 | 0.39 | 42.84 | 1.75 |
Pierangeli A. et al. (2016) [36] | 1.37 | 0.33 | 4.2042 | 0.0000 | 0.73 | 2.01 | 19.79 | 0.05 | 0.50 | 45.08 | 1.82 |
Radochova V. et al. (2015) [33] | 1.37 | 0.24 | 5.7578 | 0.0000 | 0.90 | 1.83 | 11.07 | 0.44 | 0.04 | 5.25 | 1.06 |
Razavi SM. et al. (2009) [32] | 1.27 | 0.30 | 4.1703 | 0.0000 | 0.67 | 1.87 | 19.93 | 0.05 | 0.44 | 45.28 | 1.83 |
Sameera A. et al. (2015) [30] | 1.18 | 0.28 | 4.1563 | 0.0000 | 0.62 | 1.74 | 17.71 | 0.09 | 0.34 | 39.76 | 1.66 |
Zendeli-Bedejeti L. et al. (2019) [37] | 1.18 | 0.29 | 4.0781 | 0.0000 | 0.61 | 1.75 | 18.15 | 0.08 | 0.35 | 39.95 | 1.67 |
All (none removed) | 1.27 | 0.29 | 4.3800 | 0.0001 | 0.70 | 1.83 | 20.10 | 0.07 | 0.39 | 41.62 | 1.71 |
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Ślebioda, Z.; Woźniak, T.; Wyganowska, M.L. Human Papillomavirus in Oral Lichen Planus: Is There an Association? A Meta-Analysis. J. Clin. Med. 2024, 13, 3698. https://doi.org/10.3390/jcm13133698
Ślebioda Z, Woźniak T, Wyganowska ML. Human Papillomavirus in Oral Lichen Planus: Is There an Association? A Meta-Analysis. Journal of Clinical Medicine. 2024; 13(13):3698. https://doi.org/10.3390/jcm13133698
Chicago/Turabian StyleŚlebioda, Zuzanna, Tomasz Woźniak, and Marzena Liliana Wyganowska. 2024. "Human Papillomavirus in Oral Lichen Planus: Is There an Association? A Meta-Analysis" Journal of Clinical Medicine 13, no. 13: 3698. https://doi.org/10.3390/jcm13133698