Encapsulation of Active Substances in Natural Polymer Coatings
Abstract
:1. Introduction
2. The Concept of Encapsulation
3. Technologies of Encapsulation
3.1. Spray Drying
3.2. Extrusion
3.3. Coacervation
4. Encapsulation in Micro- and Nanogels
4.1. Mechanisms of Formation of Hydrogels
4.1.1. Ionic Cross-Linking
4.1.2. Covalent Cross-Linking
4.1.3. Polyelectrolyte Cross-Linking
4.1.4. Polysaccharide and Drug Conjugation
4.1.5. Self-Assembly
4.2. Hydrogel Additives
4.2.1. Chelating Agents
4.2.2. Buffers
4.2.3. Hydrophobic Substances
5. Mechanisms of Active Compound Release
5.1. Fragmentation
5.2. Diffusion and Swelling
5.3. Dissolution and Erosion (Degradation)
5.4. Release under External Conditions Control
6. Wall Materials: Natural Polymer Coatings
6.1. Polysaccharides
6.1.1. Alginates
6.1.2. Pectins
6.1.3. Starch: Amylose and Amylopectin
6.1.4. κ-Carrageenan
6.1.5. Gellan Gum
6.1.6. Xanthan Gum
6.1.7. Gum Arabic
6.1.8. Guar Gum
6.1.9. Agarose
6.1.10. Dextrin: Maltodextrin and Cyclodextrin
6.1.11. Locust Bean Gum
6.1.12. Chitosan
6.2. Proteins
6.2.1. Gelatin
6.2.2. Milk Proteins: Whey Protein and Casein
6.2.3. Soy and Pea Proteins: Legume-Based Proteins
7. Conclusions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Physical Methods | ||
Name | Description | Example |
Spray drying | cf. part 2.1 | cf. part 2.1 |
Extrusion | cf. part 2.2 | cf. part 2.2 |
Freeze drying | Involve freezing the solution containing the active substance and then reducing the surrounding pressure to allow the frozen solvent to sublimate, leaving behind a porous structure with encapsulated materials. | Encapsulation of Elsholtazia ciliata ethanolic extract using various coating materials [27]. |
Spray cooling | Atomisation of a mixture of the active substance and a liquefied lipid carrier at low temperatures, using a cooling medium to solidify the particles [28]. | Microencapsulation of heat sensitive compounds such as vitamine B12 [29]. |
Electrospinning | Use of high-voltage electric field to produce fibres of polymers encapsulating active ingredients within the fibre matrix. | Fragrance encapsulation in polyvinylalcohol matrix by emulsion electrospinning [30]. |
Electrospray | Use of a high-voltage field to create droplets from liquid solution, which then solidify to form particles. | Manufacture of poly(lactic acid) nanoparticles incorporating antithrombotic drug [31]. |
Fluidised bed coating | A coating solution is sprayed onto particles suspended in an upward air flow. As the solvent evaporates, coated particles are left behind. | Assessing the encapsulation of orange oil: a comparison between spray drying/agglomeration and fluidised bed granulation [32]. |
Chemical Methods | ||
Name | Description | Example |
Polymerisation | The encapsulation of active ingredients within the resulting polymer matrix occurs through the in situ polymerisation of monomers. | Encapsulation of the chlorinated flame retardant with poly(methyl methacrylate) and poly(1-vinyl-2-pyrrolidone) through in-situ dispersion polymerisation in supercritical carbon dioxide [33]. |
Interfacial polymerisation | Polymerisation takes place at the interface of two immiscible phases, resulting in the formation of a polymer shell around the dispersed droplets containing the active ingredient. | The microencapsulation of Cypermethrin is achieved through the interfacial polymerisation of polyuria [34]. |
Physicochemical Methods | ||
Method | Description | Example |
Double emulsion | A water-in-oil-in-water (W/O/W) or oil-in-water-in-oil (O/W/O) emulsion is formed to encapsulate hydrophilic or lipophilic ingredients within the inner phase, allowing control over the capsule architecture. | Development of a microfluidic synthesis method for advanced microparticles involves encapsulating dye within water-oil-water droplets stabilised by diblock polymers [35]. |
Emulsification | Encapsulation via the formation of an emulsion (typically oil-in-water or water-in-oil), where the active ingredient is dispersed in one phase and the polymer forms a shell around the droplets upon solvent removal. | Manufacture of delivery systems of polyphenols via formulation of oil in water emulsion [36]. |
Microemulsion | Thermodynamically stable emulsion with droplet size in the nanometer range, used for the encapsulation of active ingredients within the dispersed phase. | Encapsulation of the antibiotic Levofloxacin in a biocompatible microemulsion involving clove oil stabilised in water with tween 20 as a surfactant and 2-propanol as a co-surfactant [37]. |
Coacervation | Simple coacervation is a physical approach Complex coacervation chemical is a chemical approach. | cf. part 2.3 |
Solvent in chemical reaction | Use of solvents in reactions to facilitate encapsulation through methods such as solvent evaporation, nanoprecipitation, or other reaction-based encapsulation techniques. | Synthesis of Poly(lactic-coglycolic acid) microspheres prepared by evaporation of dichloromethane and dimethylsulfoxide [38]. |
Layer-by-layer | Sequential deposition of alternating layers of oppositely charged polymers onto a core material, creating a multilayered shell around the core. | Encapsulation of probiotics for delivery to the microbiome by deposition of successive layers of chitosan and alginate around bacteria [39]. |
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Akpo, E.; Colin, C.; Perrin, A.; Cambedouzou, J.; Cornu, D. Encapsulation of Active Substances in Natural Polymer Coatings. Materials 2024, 17, 2774. https://doi.org/10.3390/ma17112774
Akpo E, Colin C, Perrin A, Cambedouzou J, Cornu D. Encapsulation of Active Substances in Natural Polymer Coatings. Materials. 2024; 17(11):2774. https://doi.org/10.3390/ma17112774
Chicago/Turabian StyleAkpo, Emma, Camille Colin, Aurélie Perrin, Julien Cambedouzou, and David Cornu. 2024. "Encapsulation of Active Substances in Natural Polymer Coatings" Materials 17, no. 11: 2774. https://doi.org/10.3390/ma17112774