The Efficacy and Tolerability of Radiosurgery in Treating Benign Meningiomas: A Dose Comparison Study from a Single-Center Analysis
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Demographics
3.2. Tumor Control
3.3. Radiation-Induced Toxicity
4. Discussion
Limitations of the Present Study
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Characteristics | Number (n = 147) |
---|---|
Sex (M/F) | 35/112 |
Mean age in years (range) | 61 (37–79) |
Clinical presentation | |
Asymptomatic | 81 |
Headache | 26 |
Dizziness | 18 |
Visual symptoms | 4 |
Nausea | 1 |
Motor weakness | 3 |
Hearing decline or loss | 2 |
Facial pain or numbness | 4 |
Facial palsy | 2 |
Tremor | 3 |
Seizure | 1 |
Others | 2 |
Neurologic manifestation | |
Nonspecific | 134 |
Hemiparesis | 4 |
Dysesthesia | 2 |
Visual decline | 1 |
6th nerve palsy | 2 |
7th nerve palsy | 2 |
8th nerve dysfunction | 2 |
Pathology | |
Meningothelial | 14 |
Angiomatous | 2 |
Fibroblastic | 1 |
Microcystic | 1 |
Transitional | 4 |
Mixed | 3 |
No pathological diagnosis | 122 |
Tumor location (164 lesions) | |
Skull base | 60 |
Convexity | 42 |
Parasagittal | 5 |
Falcine/tentorium | 56 |
Intraventricular | 1 |
Group 1 | Group 2 | p Value | |
---|---|---|---|
Number of lesions | 61 | 103 | |
Lesion location (skull base/non-skull base) | 24/37 | 36/67 | 0.572 |
Target volume (cm3, mean ± SD) | 1.75 ± 1.62 | 1.90 ± 2.24 | 0.628 |
Coverage (%, mean ± SD) | 99.48 ± 0.69 | 99.43 ± 0.61 | 0.653 |
Conformity index (mean ± SD) | 1.76 ± 0.40 | 1.72 ± 0.51 | 0.630 |
Prescription dose (Gy, mean, range) | 15 (14–16) | 13 (12–13.5) | <0.001 |
Maximum dose (Gy, mean, range) | 17.3 (16.0–20.4) | 15.8 (14.2–23.6) | <0.001 |
Minimum dose (Gy, mean, range) | 13.5 (7.5–15.2) | 11.5 (5.8–14.4) | <0.001 |
Mean dose (Gy, mean, range) | 16.4 (15.3–19.0) | 14.9 (12.8–19.2) | <0.001 |
Outcomes | Total (164 Lesions) | Group 1 (61 Lesions) | Group 2 (103 Lesions) |
---|---|---|---|
Mean follow-up duration (months) | 47 (range: 12–122) | 68 (range: 12–122) | 35 (range: 12–119) |
Overall tumor control rate | 156/164 (95.1%) | 57/61 (93.4%) | 99/103 (96.1%) |
Complete response | 0 | 0 | 0 |
Partial response | 10 (6.1%) | 4 (6.6%) | 6 (5.8%) |
Minimal response | 12 (7.3%) | 8 (13.1%) | 4 (3.9%) |
Stable | 134 (81.7%) | 45 (73.7%) | 89 (86.4%) |
Progression | 8 (4.9%) | 4 (6.6%) | 4 (3.9%) |
Radiation-induced peritumoral edema | 21 (12.8%) | 12 (19.7%) | 9 (8.7%) |
CTCAE 1–2 | 16 (9.8%) | 8 (13.1%) | 8 (7.7%) |
CTCAE 3–4 | 5 (3.0%) | 4 (6.6%) | 1 (1.0%) |
Factor | Univariate | Multivariate | |||
---|---|---|---|---|---|
p Value | HR | 95% CI | p Value | ||
Local tumor control | Age > 65 years | 0.404 | |||
Female sex | 0.449 | ||||
Tumor volume > 10 cm3 | <0.001 | 48.651 | 4.672–506.611 | 0.001 | |
Marginal dose ≥ 14 Gy | 0.628 | ||||
Location (skull base/non-skull base) | 0.728 | ||||
Prior surgery | 0.004 | 7.806 | 1.735–35.110 | 0.007 |
Factor | Univariate | Multivariate | |||
---|---|---|---|---|---|
p Value | HR | 95% CI | p Value | ||
Peritumoral edema | Age > 65 years | 0.353 | |||
Female sex | 0.232 | ||||
Tumor volume > 10 cm3 | 0.017 | 14.242 | 1.782–113.844 | 0.012 | |
Marginal dose ≥ 14 Gy | 0.039 | 2.189 | 0.894–5.365 | 0.087 | |
Location (skull base/non-skull base) | 0.200 | ||||
Prior surgery | 0.320 | ||||
Pre-existing peritumoral edema | <0.001 | 12.426 | 4.616–33.453 | <0.001 |
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Cho, H.-J.; Lee, J.-M.; Park, S.-H.; Park, J.-B.; Jung, N.-Y. The Efficacy and Tolerability of Radiosurgery in Treating Benign Meningiomas: A Dose Comparison Study from a Single-Center Analysis. Life 2024, 14, 664. https://doi.org/10.3390/life14060664
Cho H-J, Lee J-M, Park S-H, Park J-B, Jung N-Y. The Efficacy and Tolerability of Radiosurgery in Treating Benign Meningiomas: A Dose Comparison Study from a Single-Center Analysis. Life. 2024; 14(6):664. https://doi.org/10.3390/life14060664
Chicago/Turabian StyleCho, Hyun-Jeong, Jong-Min Lee, Sung-Ho Park, Jun-Bum Park, and Na-Young Jung. 2024. "The Efficacy and Tolerability of Radiosurgery in Treating Benign Meningiomas: A Dose Comparison Study from a Single-Center Analysis" Life 14, no. 6: 664. https://doi.org/10.3390/life14060664