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Open AccessArticle
Major Depressive Disorder with Catatonia: A Phenotype Related to Autistic Traits and High Suicidality
by
Barbara Carpita
Barbara Carpita ,
Giulia Amatori
Giulia Amatori *,
Ivan Mirko Cremone
Ivan Mirko Cremone ,
Chiara Bonelli
Chiara Bonelli ,
Benedetta Nardi
Benedetta Nardi
,
Gabriele Massimetti
Gabriele Massimetti
,
Stefano Pini
Stefano Pini and
Liliana Dell’Osso
Liliana Dell’Osso
Department of Clinical and Experimental Medicine, Section of Psychiatry, University of Pisa, 67 Via Roma, 56126 Pisa, Italy
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2024, 13(16), 4796; https://doi.org/10.3390/jcm13164796 (registering DOI)
Submission received: 23 May 2024
/
Revised: 19 July 2024
/
Accepted: 12 August 2024
/
Published: 14 August 2024
Abstract
Background: Major Depressive Disorder (MDD) represents a significant global health concern, often complicated by comorbidities such as catatonia and autism spectrum disorder (ASD). Recognizing the interplay among these conditions and their impact on suicidal tendencies is crucial for effective clinical management. Methods: A total sample of 147 subjects with MDD was divided into Significant Catatonia (SC) and Non-Significant Catatonia (NSC) groups based on Catatonia Spectrum (CS) scores. Participants were evaluated through the Structured Clinical Interview for DSM-5, Research Version (SCID-5-RV), the Adult Autism Subtreshold Spectrum (AdAS Spectrum), and the Mood Spectrum—Self Report questionnaires. Statistical analyses included Mann–Whitney U test, Chi-square test, logistic regression analyses, and a decision tree model. Results: The SC group exhibited higher CS, AdAS Spectrum, and MOODS-SR total and domain scores compared to the NSC group. Individuals with significant autistic traits were over-represented in the SC group, as well as participants with higher suicidality, suicidal ideation, and a history of suicide attempts. The total AdAS Spectrum and MOOD-SR score, the AdAS domain “Hyper-hypo reactivity to sensory input”, and the “Cognitive depressive” MOOD-SR domain were predictive of belonging to the SC group Suicidality levels appeared to be higher in clinically significant ASD, intermediate in subjects with autistic traits (AT), and low in the absence of AT. Conclusions: the study suggests the existence of a specific phenotype of MDD associated with catatonia, characterized by elevated autistic traits and suicide risk.
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MDPI and ACS Style
Carpita, B.; Amatori, G.; Cremone, I.M.; Bonelli, C.; Nardi, B.; Massimetti, G.; Pini, S.; Dell’Osso, L.
Major Depressive Disorder with Catatonia: A Phenotype Related to Autistic Traits and High Suicidality. J. Clin. Med. 2024, 13, 4796.
https://doi.org/10.3390/jcm13164796
AMA Style
Carpita B, Amatori G, Cremone IM, Bonelli C, Nardi B, Massimetti G, Pini S, Dell’Osso L.
Major Depressive Disorder with Catatonia: A Phenotype Related to Autistic Traits and High Suicidality. Journal of Clinical Medicine. 2024; 13(16):4796.
https://doi.org/10.3390/jcm13164796
Chicago/Turabian Style
Carpita, Barbara, Giulia Amatori, Ivan Mirko Cremone, Chiara Bonelli, Benedetta Nardi, Gabriele Massimetti, Stefano Pini, and Liliana Dell’Osso.
2024. "Major Depressive Disorder with Catatonia: A Phenotype Related to Autistic Traits and High Suicidality" Journal of Clinical Medicine 13, no. 16: 4796.
https://doi.org/10.3390/jcm13164796
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