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Brain Sciences
Special Issues
Application of Brain Imaging in Mental Illness
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Application of Brain Imaging in Mental Illness

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurotechnology and Neuroimaging".

Deadline for manuscript submissions: 25 October 2024 | Viewed by 686

Special Issue Editor

Dr. Kristina Hennig-Fast

E-Mail Website
Guest Editor
Department of Psychiatry and Psychotherapy, University of Bielefeld, 33615 Bielefeld, Germany
Interests: neuroscience; biological psychology and psychiatry; stress-related disorders and resilience; mental illness; neuropsychology; psychotherapy; emotion and social regulation; memory and self; attachment

Special Issue Information

Dear Colleagues,

Mental illnesses as psychiatric and psychosomatic diagnoses are still mainly based on clinical syndromes rather than measurable biophysiological abnormalities.

Progress in neuroimaging technology and analytical methods has supported:

  • research into subtle but measurable radiological characteristics of mental diseases;
  • experimental classification of psychiatric disorders;
  • prediction of response to treatment;
  • development of innovative effective therapies.

Mental illnesses likely arise from disturbances of connectivity in neural networks, rather than anatomy, and can be understood as disorders of structural/functional disintegration.

This Special Issue highlights advances in neuroimaging modalities that are now allowing assessment of brain structures, connectivity, and neural network functions; describes technical aspects of the most promising methods; and report observations made in mental illnesses.

We welcome contributions relating to:

  • neuroimaging biomarkers;
  • structural and functional neural alterations;
  • the role of neuroimaging in predicting treatment responses;
  • novel neuroimaging techniques;
  • implications of using neuroimaging in the diagnosis and treatment of mental illnesses.

Dr. Kristina Hennig-Fast
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neuroimaging
  • brain imaging
  • mental illnesses
  • psychiatric disorders

Published Papers (1 paper)

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Research

16 pages, 1299 KiB  
Article
Two Sides of the Same Coin in Female Borderline Personality Disorder: Self-Reported Guilt and Shame and Their Neurofunctional Correlates
by Hella Parpart, Jakob Blass, Thomas Meindl, Janusch Blautzik, Petra Michl, Thomas Beblo, Rolf Engel, Maximilian Reiser, Peter Falkai, Hans-Juergen Moeller, Martin Driessen and Kristina Hennig-Fast
Brain Sci. 2024, 14(6), 549; https://doi.org/10.3390/brainsci14060549 - 27 May 2024
Viewed by 376
Abstract
Objective: Patients with borderline personality disorder (BPD) report to be especially prone to social emotions like shame and guilt. At the same time, these emotions seem to play an important role in BPD pathology. The present study aimed to deepen the knowledge about [...] Read more.
Objective: Patients with borderline personality disorder (BPD) report to be especially prone to social emotions like shame and guilt. At the same time, these emotions seem to play an important role in BPD pathology. The present study aimed to deepen the knowledge about the processes behind shame and guilt in patients with BPD. Methods: Twenty patients with BPD and twenty healthy controls (HCs) took part in an experiment that induced shame and guilt by imagining scenarios during scanning using functional brain imaging. Participants also filled out self-report questionnaires and took part in diagnostic interviews. Results: BPD patients reported more proneness to guilt but not to shame than the HCs. There was no difference in the self-reported intensity rating of experimentally induced emotions between the groups. Between-group contrast of neural signals in the shame condition revealed a stronger activation of cingulate and fusiform gyrus for the BPD patients compared to the controls, and a more pronounced activation in the lingual gyrus and cuneus for the HCs. In the guilt condition, activation in the caudate nucleus, the fusiform gyrus, and the posterior cingulate cortex was stronger in BPD patients, while HC showed stronger activations in cuneus, lingual gyrus, and fronto-temporal regions. Conclusions: Differences in the neuro-functional processes between BPD patients and HC were found, even though the two groups did not differ in their self-report of subjective proneness to guilt and emotional intensity of shame and guilt during the experiment. While the HCs may be engaged more by the emotional scenarios themselves, the BPD patients may be more occupied with cognitive regulatory and self-referential processing. Full article
(This article belongs to the Special Issue Application of Brain Imaging in Mental Illness)
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