Novel Mechanisms and Therapeutic Opportunities of Ferroptosis
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Microenvironment".
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 55251
Special Issue Editors
Interests: ferroptosis; cancer
Interests: ferroptosis; cancer
Interests: ferroptosis; cancer
Interests: cell death modes (ferroptosis, pyroptosis, necroptosis) mechanisms and targeted drug discovery
Interests: Alzheimer’s disease; neuroinflammation; B-lymphocyte; T-lymphocyte; aging; tumor
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Ferroptosis is a newly identified regulated cell death modality with unique characteristics compared to apoptosis and other types of cell death. Ferroptosis is caused by the disruption of several key metabolic pathways (including the ROS, amino acid, and lipid metabolism pathways) in the cell and is dependent on iron. There are three basic elements for ferroptosis: the substrate of lipid peroxidation, the executor of lipid peroxidation, and the anti-ferroptosis system.
The past decade witnessed the rapid progress in ferroptosis research, both in terms of its molecular mechanism and disease relevance. Classical models of ferroptosis highlight the central role of ACSL4 in the synthesis of the lipid peroxidation substrate, ALOXs as executors of lipid peroxidation, and GPX4 for ferroptosis suppression. Ferroptosis has been demonstrated to be involved in normal development and diverse disorders, including ischemic organ injuries, neurodegenerative diseases, immune system activities, and tumors. The pathological relevance of ferroptosis provides new therapeutic opportunities for these diseases.
As research on ferroptosis goes deeper, novel mechanisms of ferroptosis that are beyond the classical model are emerging. For example, p53-mediated ferroptosis has been proven to be as much of a distinct pathway as GPX4-centered ferroptosis. More and more regulators of ferroptosis are being identified. In addition, ferroptosis exhibits many more roles than expected in the initiation and development of various diseases. More efforts should be made to determine the novel mechanisms and therapeutic opportunities of ferroptosis.
This Special Issue aims to collect papers about how ferroptosis is regulated and how ferroptosis pathways can be targeted to treat diverse diseases. We welcome papers about novel/non-canonical ferroptosis pathways and new drugs therapeutic methods targeting ferroptosis.
Original research articles, reviews, and mini-reviews are welcome in this collection. Topics of interest include but are not limited to the follow:
- Novel mechanisms and regulators of ferroptosis;
- The role of p53 in both canonical and non-canonical ferroptosis regulation;
- Targeting ferroptosis for the treatment of various diseases.
Please note that the findings based on bioinformatic data mining should be validated by experiments.
Dr. Yanqing Liu
Dr. Zhenyi Su
Prof. Dr. Chaoyun Pan
Prof. Dr. Lianxiang Luo
Dr. Xin Wang
Guest Editors
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Keywords
- ferroptosis
- p53
- metabolism
- disease treatment
- tumor
- ischemic organ injury
- neurodegenerative disease
- immune system function
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