Svoboda | Graniru | BBC Russia | Golosameriki | Facebook
 
 
ijms-logo

Journal Browser

Journal Browser

Molecular Research on Olfactory and Gustatory Receptors

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 20 November 2024 | Viewed by 2073

Special Issue Editor


E-Mail Website
Guest Editor
Institute for Genetics, Faculty of Mathematics and Natural Sciences, University of Cologne, Zülpicher Str. 47a, 50674 Cologne, Germany
Interests: evolution; olfactory and taste receptors; evolution of function; olfactory coding

Special Issue Information

Dear Colleagues,

Olfaction and taste are the two main chemosensory systems of vertebrates and arthropods. In vertebrates, four olfactory and two taste receptor families (OR, TAAR, V1R, V2R, T1R, T2R) mediate the detection of odorants and tastants, whereas in insects, three unrelated receptor families (OR, IR, GR) perform these tasks. A hallmark of these families is dynamic evolution, characterized by many gene birth and death events. This is assumed to be according to the ecological needs of the respective species, but our understanding of such adaptations is incomplete. In particular, functional studies addressing these receptors remain very limited. Recent advances in high-throughput sequencing have enabled the characterization of chemosensory families in ever more species, and thus their adaptation to a wide variety of ecological contexts has come to the fore. Moreover, the manifold regulation of expression (developmental age, exposure, internal states) results in dynamic receptor repertoires, even within a species and organism.

For this Special Issue, we invite original research articles that showcase the evolution, function or regulation of olfactory or gustatory receptors (vertebrates and insects, as well as studies on other invertebrates). Critical reviews of recent advances in the field are also welcome.

Prof. Dr. Sigrun I. Korsching
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • olfactory receptor
  • gustatory receptor
  • taste and smell
  • evolution of function
  • regulation of expression
  • olfactory coding
  • vertebrates
  • insects
  • non-model organisms

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

17 pages, 4994 KiB  
Article
First Immunohistochemical Demonstration of the Expression of a Type-2 Vomeronasal Receptor, V2R2, in Wild Canids
by Irene Ortiz-Leal, Mateo V. Torres, Ana López-Beceiro, Luis Fidalgo, Taekyun Shin and Pablo Sanchez-Quinteiro
Int. J. Mol. Sci. 2024, 25(13), 7291; https://doi.org/10.3390/ijms25137291 - 2 Jul 2024
Viewed by 770
Abstract
The mammalian vomeronasal system enables the perception of chemical signals crucial for social communication via the receptor families V1R and V2R. These receptors are linked with the G-protein subunits, Gαi2 and Gαo, respectively. Exploring the evolutionary pathways of V1Rs and V2Rs across mammalian [...] Read more.
The mammalian vomeronasal system enables the perception of chemical signals crucial for social communication via the receptor families V1R and V2R. These receptors are linked with the G-protein subunits, Gαi2 and Gαo, respectively. Exploring the evolutionary pathways of V1Rs and V2Rs across mammalian species remains a significant challenge, particularly when comparing genomic data with emerging immunohistochemical evidence. Recent studies have revealed the expression of Gαo in the vomeronasal neuroepithelium of wild canids, including wolves and foxes, contradicting predictions based on current genomic annotations. Our study provides detailed immunohistochemical evidence, mapping the expression of V2R receptors in the vomeronasal sensory epithelium, focusing particularly on wild canids, specifically wolves and foxes. An additional objective involves contrasting these findings with those from domestic species like dogs to highlight the evolutionary impacts of domestication on sensory systems. The employment of a specific antibody raised against the mouse V2R2, a member of the C-family of vomeronasal receptors, V2Rs, has confirmed the presence of V2R2-immunoreactivity (V2R2-ir) in the fox and wolf, but it has revealed the lack of expression in the dog. This may reflect the impact of domestication on the regression of the VNS in this species, in contrast to their wild counterparts, and it underscores the effects of artificial selection on sensory functions. Thus, these findings suggest a more refined chemical detection capability in wild species. Full article
(This article belongs to the Special Issue Molecular Research on Olfactory and Gustatory Receptors)
Show Figures

Figure 1

16 pages, 7282 KiB  
Article
Localized Expression of Olfactory Receptor Genes in the Olfactory Organ of Common Minke Whales
by Ayumi Hirose, Gen Nakamura, Masato Nikaido, Yoshihiro Fujise, Hidehiro Kato and Takushi Kishida
Int. J. Mol. Sci. 2024, 25(7), 3855; https://doi.org/10.3390/ijms25073855 - 29 Mar 2024
Viewed by 1041
Abstract
Baleen whales (Mysticeti) possess the necessary anatomical structures and genetic elements for olfaction. Nevertheless, the olfactory receptor gene (OR) repertoire has undergone substantial degeneration in the cetacean lineage following the divergence of the Artiodactyla and Cetacea. The functionality of highly degenerated [...] Read more.
Baleen whales (Mysticeti) possess the necessary anatomical structures and genetic elements for olfaction. Nevertheless, the olfactory receptor gene (OR) repertoire has undergone substantial degeneration in the cetacean lineage following the divergence of the Artiodactyla and Cetacea. The functionality of highly degenerated mysticete ORs within their olfactory epithelium remains unknown. In this study, we extracted total RNA from the nasal mucosae of common minke whales (Balaenoptera acutorostrata) to investigate ORs’ localized expression. All three sections of the mucosae examined in the nasal chamber displayed comparable histological structure. However, the posterior portion of the frontoturbinal region exhibited notably high OR expression. Neither the olfactory bulb nor the external skin exhibited the expression of these genes. Although this species possesses four intact non-class-2 ORs, all the ORs expressed in the nasal mucosae belong to class-2, implying the loss of aversion to specific odorants. These anatomical and genomic analyses suggest that ORs are still responsible for olfaction within the nasal region of baleen whales, enabling them to detect desirable scents such as prey and potential mating partners. Full article
(This article belongs to the Special Issue Molecular Research on Olfactory and Gustatory Receptors)
Show Figures

Graphical abstract

Back to TopTop