Genetic Research in Neurological Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 31 August 2024 | Viewed by 802
Special Issue Editor
Interests: neurodegeneration; Alzheimer disease; genetics; diagnosis; prion disease
Special Issue Information
Dear Colleagues,
Neurodegenerative diseases are major health issues that affect every population all around the world. Genetics plays a significant role in neurodegeneration, and genetic mutations could be either causative factors, risk factors, or risk modifiers. Mutations in the disease-causing or risk genes could lead to the impairment of neurological functions, leading to various diseases, including Alzheimer’s disease, frontotemporal dementia, prion diseases, Parkinson’s disease, small-vessel diseases, or other motor diseases, including amyotrophic lateral sclerosis and different kinds of ataxias or spastic paraplegias. These diseases may be inherited autosomal dominantly or autosomal recessively. Genome-wide association studies and next-generation sequencing studies (whole-genome or whole-exome) accelerated the gene and mutation discovery of genetic forms of neurodegenerative diseases. Furthermore, in vitro or in vivo models of possibly pathogenic mutations should be essential to discovering the potential pathogenic mechanisms associated with these diseases. Determining the disease-related mechanisms may also help the therapeutic research on these diseases.
This Special Issue aims to provide an overview of the current research on the promising discoveries in the genetics of neurodegenerative diseases, potential disease-related mutations, and cell models associated with genetic findings in neurodegenerative diseases. Review, research articles, and case reports are welcome.
Dr. Eva Bagyinszky
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- neurodegenerative diseases
- genetic risk factor
- next-genetation sequencing
- genome-wide association studies
- disease models
