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Clinical Challenges in Transplant Infectious Diseases

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Special Issue Editors

Dr. Justyna E. Gołȩbiewska

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Guest Editor

Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdańsk, ul. Dębinki 7, 80-952 Gdańsk, Poland
Interests: kidney transplantation; transplant infectious diseases; immunosuppression; clinical nephrology; novel biomarkers; pancreatic islet transplantation
Special Issues, Collections and Topics in MDPI journals

Prof. Dr. Alicja Dębska-Ślizień

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Guest Editor

Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdańsk, ul. Dębinki 7, 80-952 Gdańsk, Poland
Interests: kidney transplantation; onconephrology; anemia of chronic diseases; clinical nephrology; cystic kidney diseases
Special Issues, Collections and Topics in MDPI journals

Dr. Dorota Kaminska

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Guest Editor

Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, ul. Borowska 213, 50-529 Wrocław, Poland
Interests: transplant; nephrology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Solid organ transplants (SOTs) are life-saving interventions. New potent immunosuppressive strategies have enabled transplantations in high immunological risk patients, retransplantations, or ABO-incompatible transplantations at the expense of an increased recipients’ susceptibility to various infections. Despite targeted prophylaxis, surveillance, and risk stratification, infectious complications remain a major cause of morbidity and a principal cause of death in this population. SOT recipients experience a high burden of infections with a specific temporal pattern, with rare opportunistic pathogens and a predominance of bacteria. Over the last decade, multidrug resistance has been a rising concern, especially in a vulnerable population of SOT recipients.

In this Special Issue of the journal Medicina, we will address the whole spectrum of infectious complications in SOT recipients, including bacterial, fungal, and viral infections. Comprehensive reviews as well as research (be it basic, translational, or clinical research) or interesting case series or case reports are welcome, with the aim of providing readers with an up-to-date view on the screening, prophylaxis, diagnosis, and management of transplant infectious diseases.

Dr. Justyna E. Gołȩbiewska
Prof. Dr. Alicja Dębska-Ślizień
Dr. Dorota Kaminska
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

bacterial, viral, and fungal infections
multidrug resistance
opportunistic infections
prophylaxis
monitoring of infection
management of infection

Published Papers (2 papers)

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Review

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17 pages, 762 KiB

Open AccessReview

Asymptomatic Bacteriuria in Kidney Transplant Recipients—A Narrative Review

by Justyna E. Gołębiewska, Beata Krawczyk, Magdalena Wysocka, Aleksandra Dudziak and Alicja Dębska-Ślizień

Medicina 2023, 59(2), 198; https://doi.org/10.3390/medicina59020198 - 19 Jan 2023

Cited by 3 | Viewed by 2549

Abstract

Urinary tract infections (UTIs) are the most prevalent complications in kidney transplant (KTx) recipients. The most frequent finding in this group of patients is asymptomatic bacteriuria (ASB). Here, we provide an overview of the available evidence regarding ASB in KTx recipients, including its etiopathology, clinical impact and management. There is a growing body of evidence from clinical trials that screening for and treating ASB is not beneficial in most KTx recipients. However, there are insufficient data to recommend or discourage the use of a “screen-and-treat strategy” for ASB during the first 1–2 months post-transplant or in the case of an indwelling urinary catheter. Despite its frequency, ASB after KTx is still an understudied phenomenon. Full article

(This article belongs to the Special Issue Clinical Challenges in Transplant Infectious Diseases)

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Other

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8 pages, 828 KiB

Open AccessCase Report

Multiple Post-SARS-COV2 Infectious Complications in Kidney Transplant Recipient

by Patrycja Grzejszczak, Agnieszka Płuciennik, Anna Kumor-Kisielewska and Ilona Kurnatowska

Medicina 2022, 58(10), 1370; https://doi.org/10.3390/medicina58101370 - 29 Sep 2022

Cited by 1 | Viewed by 1517

Abstract

A forty-seven-year-old recipient in late period after kidney transplantation with chronic estimated glomerular filtration rate (eGFR) 30 mL/min/1.73 m², fully vaccinated against COVID-19 was diagnosed with SARS-CoV-2 infection in November 2021. After an initially mild course of the disease, he developed multiorgan failure requiring periodic respiratory and dialysis therapy. Covid-19 disease was complicated by multiple infections such Clostridioides difficile infection, Streptococcus epidermidis bacteriemia, Klebsiella pneumoniae and Candida glabrata urinary tract disease, cytomegalovirus infection and oral candidiasis. In a short period, he was readmitted to the hospital twice with recurrent Klebsiella pneumoniae urosepsis. One of those hospitalizations was also complicated by another COVID-19 infection that was confirmed with non-reactive neutralizing antibody. Due to severe infections the patient required individualized modification of immunotherapy; however, due to their recurrence it was finally decided to be discontinued. The patient was also reintroduced to hemodialysis therapy and no infections occurred since then. Full article

(This article belongs to the Special Issue Clinical Challenges in Transplant Infectious Diseases)

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