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Leptospirosis and One Health Approach: Current Status and Future Prospects, 2nd Edition

A special issue of Tropical Medicine and Infectious Disease (ISSN 2414-6366). This special issue belongs to the section "One Health".

Deadline for manuscript submissions: 22 December 2025 | Viewed by 1082

Special Issue Editors


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Guest Editor
Faculdade de Medicina Veterinária e Zootecnia, Universidade Federal de Campina Grande, Campina Grande 58428-830, Brazil
Interests: leptospirosis; One Health; animal leptospirosis; environment; epidemiology; control; diagnosis
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Faculdade de Medicina Veterinária e Zootecnia, Universidade Federal de Campina Grande, Campina Grande 58428-830, Brazil
Interests: leptospirosis; One Health; animal leptospirosis; environment; epidemiology; control; diagnosis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Leptospirosis is an emerging zoonotic disease of broad impact on animal production and public health that affects more than 1 million people, with 60,000 deaths per year. The infection has a strong environmental component, and exposure to soil or water contaminated with the urine of reservoir animals (mostly rodents) infected with pathogenic Leptospira is the most common way for humans or animals to contract leptospirosis. The ability of Leptospira to occupy various ecological niches suggests that the pathogen might have evolved from an environmental ancestor through the acquisition of new functions via lateral gene transfers associated with adaptation to new hosts.

In this context, studies focusing on the animal–human–environment interface are important to better understand the ecology of Leptospira in the natural environment and its interactions with animal and human populations, which will help the implementation of prevention and control efforts aimed at reducing the risk of infection.

The 2nd Edition of this Special Issue aims to address the current status and future prospects on leptospirosis in the context of a One Health approach, with a broad emphasis on the animal, human, and environment interface, and papers focusing on relevant aspects such as deeper understanding of the biodiversity of strains that can lead to infections in both humans and animals, Leptospira isolating from environmental samples, molecular epidemiology, improvement of diagnostic methods, and new epidemiological insights are particularly welcome. We invite the submission of reviews, reports, and original research articles.

Dr. Sérgio Santos de Azevedo
Dr. Clebert José Alves
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • leptospirosis
  • one health
  • animal leptospirosis
  • environment
  • epidemiology
  • control
  • diagnosis

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Published Papers (1 paper)

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Research

14 pages, 923 KiB  
Article
Detection of Genes Related to Antibiotic Resistance in Leptospira
by Santiago Pineda, Juliana María Martínez Garro, Jorge Emilio Salazar Flórez, Sergio Agudelo-Pérez, Fernando P. Monroy and Ronald Guillermo Peláez Sánchez
Trop. Med. Infect. Dis. 2024, 9(9), 203; https://doi.org/10.3390/tropicalmed9090203 - 6 Sep 2024
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Abstract
Leptospirosis is a disease caused by the bacteria of the Leptospira genus, which can usually be acquired by humans through contact with urine from infected animals; it is also possible for this urine to contaminate soils and bodies of water. The disease can [...] Read more.
Leptospirosis is a disease caused by the bacteria of the Leptospira genus, which can usually be acquired by humans through contact with urine from infected animals; it is also possible for this urine to contaminate soils and bodies of water. The disease can have deadly consequences in some extreme cases. Fortunately, until now, patients with leptospirosis have responded adequately to treatment with doxycycline and azithromycin, and no cases of antibiotic resistance have been reported. However, with the extensive use of such medications, more bacteria, such as Staphylococci and Enterococci, are becoming resistant. The purpose of this study is to determine the presence of genes related to antibiotic resistance in the Leptospira genus using bioinformatic tools, which have not been undertaken in the past. Whole genomes from the 69 described Leptospira species were downloaded from NCBI’s GeneBank and analyzed using CARD (The Comprehensive Antibiotic Resistant Database) and RAST (Rapid Annotations using Subsystem Technology). After a detailed genomic search, 12 genes associated with four mechanisms were found: resistance to beta-lactamases, vancomycin, aminoglycoside adenylyltransferases, as well as multiple drug efflux pumps. Some of these genes are highly polymorphic among different species, and some of them are present in multiple copies in the same species. In conclusion, this study provides evidence of the presence of genes related to antibiotic resistance in the genomes of some species of the genus Leptospira, and it is the starting point for future experimental evaluation to determine whether these genes are transcriptionally active in some species and serovars. Full article
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